EFSA Compendium of Botanicals

Draft - work in progress

Anemarrhena asphodeloides Bunge

Family:: Asparagaceae
Approval state:: Approved
Number of articles retrieved:: 1015
Number of processed references:: 2

Compositions

Endpoint Studies

Genotoxicity

Composition #1: Wu, Xiaoyi., Chao, Zhimao., Wang, Chun., Yu, Li. Separation of chemical constituents from three plant medicines by counter-current chromatography using a three-phase solvent system at a novel ratio. JOURNAL OF CHROMATOGRAPHY A, 2015, vol. 1384, p. 107–114. DOI: 10.1016/j.chroma.2015.01.057. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

Saponins (RF-00004333-PAR)
Additional substance description:

Timosaponin A
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Timosaponin A

Endpoint study #1: Wu, Zhi-tao., Qi, Xin-ming., Sheng, Jing-jing., Ma, Lei-lei., Ni, Xuan., Ren, Jin., Huang, Cheng-gang., Pan, Guo-yu. Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters. ACTA PHARMACOLOGICA SINICA, 2014, vol. 35, no. 9, p. 1188–1198. DOI: 10.1038/aps.2014.65. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Unspecified (A07XD)
Additional plant/substance description:

timosaponin A3 from Anemarrhena aphodeloides
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Male
Route of exposure:

ORAL: GAVAGE (OECD2231PL)
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Microgram/kilogram (G050A)
Effect concentration:

100
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

TA3 may produce cholestasis and potential liver injury
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

hepatotoxicity