EFSA Compendium of Botanicals

Draft - work in progress

Amsinckia menziesii var. intermedia (Fisch. & C.A.Mey.) Ganders // Echium menziesii Lehm.

Family:: Boraginaceae
Approval state:: Approved
Number of articles retrieved:: 23
Number of processed references:: 1

Compositions

#1: 3'-acetyllycopsamine #2: lycopsamine #3: 3',7-diacetyllycopsamine #4: 7-acetyllycopsamine #5: intermedine

Endpoint Studies

#1: liver damage/horse #2: liver damage/swine #3: liver damage/cattle

Genotoxicity

Composition #1: ROITMAN, JN. THE PYRROLIZIDINE ALKALOIDS OF AMSINCKIA-MENZIESII. AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, vol. 36, no. 4, p. 769–778. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Additional substance description:

3'-acetyllycopsamine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, optical rotations, MS, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

3'-acetyllycopsamine

Composition #2: ROITMAN, JN. THE PYRROLIZIDINE ALKALOIDS OF AMSINCKIA-MENZIESII. AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, vol. 36, no. 4, p. 769–778. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Lycopsamine (RF-00000228-TOX)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, optical rotations, MS, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

lycopsamine

Composition #3: ROITMAN, JN. THE PYRROLIZIDINE ALKALOIDS OF AMSINCKIA-MENZIESII. AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, vol. 36, no. 4, p. 769–778. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Additional substance description:

3',7-diacetyllycopsamine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, optical rotations, MS, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

3',7-diacetyllycopsamine

Composition #4: ROITMAN, JN. THE PYRROLIZIDINE ALKALOIDS OF AMSINCKIA-MENZIESII. AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, vol. 36, no. 4, p. 769–778. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

7-acetyllycopsamine (RF-00000265-TOX)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, optical rotations, MS, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

7-acetyllycopsamine

Composition #5: ROITMAN, JN. THE PYRROLIZIDINE ALKALOIDS OF AMSINCKIA-MENZIESII. AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, vol. 36, no. 4, p. 769–778. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Intermedine (RF-00000227-TOX)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, optical rotations, MS, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

intermedine

Endpoint study #1: ROITMAN, JN. THE PYRROLIZIDINE ALKALOIDS OF AMSINCKIA-MENZIESII. AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, vol. 36, no. 4, p. 769–778. .

Study relevance:

Human health
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Horse (as animal) (A0B9Z)
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

liver damage
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

liver damage/horse

Endpoint study #2: ROITMAN, JN. THE PYRROLIZIDINE ALKALOIDS OF AMSINCKIA-MENZIESII. AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, vol. 36, no. 4, p. 769–778. .

Study relevance:

Human health
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Pig (as animal) (A057F)
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

liver damage
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

liver damage/swine

Endpoint study #3: ROITMAN, JN. THE PYRROLIZIDINE ALKALOIDS OF AMSINCKIA-MENZIESII. AUSTRALIAN JOURNAL OF CHEMISTRY, 1983, vol. 36, no. 4, p. 769–778. .

Study relevance:

Human health
Substance:

Pyrrolizidine alkaloids (RF-00000230-TOX)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Route of exposure:

ORAL: FEED (OECD2230PL)
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

liver damage
Effect or parameter linked to the endpoint:

not reported (CHD030BE)
Internal remarks:

liver damage/cattle