EFSA Compendium of Botanicals

Draft - work in progress

Dwarf copperleaf (as plant) // ALRSE // Alternanthera sessilis (L.) R.Br. ex DC.

Family:: Amaranthaceae
Approval state:: Approved
Number of articles retrieved:: 357
Number of processed references:: 4

Compositions

Endpoint Studies

#1: degenerative and necrotic changes in the kidney #2: degenerative and necrotic changes in the liver

Genotoxicity

Composition #1: Anitha, R., Kanimozhi, S. Pharmacognostic Evaluation of Alternanthera Sessilis (L.) R.Br.ex.DC. pharmacognosy journal, 2012, vol. 4, no. 28, p. 31–34. DOI: 10.5530/pj.2012.28.6. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins

Composition #2: Dhole, J.A., Dhole, N.A., Lone, K.D., Bodke, S.S. Preliminary phytochemical analysis of weeds in Marathwada region. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2012, vol. 3, no. 4, p. 764–767. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins

Composition #3: Mondal, Himangsu., Saha, Sanjib., Awang, Khalijah., Hossain, Hemayet., Ablat, Abdulwali., Islam, Md Khirul., Jahan, Ismet Ara., Sadhu, Samir K., Hossain, Md Golam., Shilpi, Jamil A., Uddin, Shaikh J. Central-stimulating and analgesic activity of the ethanolic extract of Alternanthera sessilis in mice. BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2014, vol. 14 . DOI: 10.1186/1472-6882-14-398. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids

Endpoint study #1: Gayathri, B. M., Balasuriya, K., de S Gunawardena, G. S. Panduka., Rajapakse, R. P. V. Jayantha., Dharmaratne, H. Ranjith W. Toxicological studies of the water extract of green leafy vegetable Sessile joy weed (Alternanthera sessilis). CURRENT SCIENCE, 2006, vol. 91, no. 11, p. 1517–1520. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Water
Type of toxicological test:

short-term toxicity (CHD017TT)
Limit test:

No data
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

20
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram (G155A)
Effect concentration:

67.6
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

degenerative and necrotic changes in the kidney
Effect or parameter linked to the endpoint:

urinalysis (CHD029BE)
Internal remarks:

degenerative and necrotic changes in the kidney

Endpoint study #2: Gayathri, B. M., Balasuriya, K., de S Gunawardena, G. S. Panduka., Rajapakse, R. P. V. Jayantha., Dharmaratne, H. Ranjith W. Toxicological studies of the water extract of green leafy vegetable Sessile joy weed (Alternanthera sessilis). CURRENT SCIENCE, 2006, vol. 91, no. 11, p. 1517–1520. .

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

Water
Type of toxicological test:

short-term toxicity (CHD017TT)
Limit test:

No data
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male/Female
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

14.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

20
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram (G155A)
Effect concentration:

67.6
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

degenerative and necrotic changes in the liver
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

degenerative and necrotic changes in the liver