EFSA Compendium of Botanicals

Draft - work in progress

Alstonia scholaris (L.) R.Br.

Family:: Apocynaceae
Approval state:: Approved
Number of articles retrieved:: 728
Number of processed references:: 3

Compositions

#1: Methly salicylate #2: indole alkaloids

Endpoint Studies

Genotoxicity

Composition #1: Dung, NX., Ngoc, PH., Rang, DD., Nhan, NT., Klinkby, N., Ledercq, P. Chemical composition of the volatile concentrate from the flowers of Vietnamese Alstonia scholaris (L.) R.Br, Apocynaceae. JOURNAL OF ESSENTIAL OIL RESEARCH, 2001, vol. 13, no. 6, p. 424–426. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Hexane extraction + hydrodistillation
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent Area (G139A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1
Internal remarks:

Methly salicylate

Composition #2: Feng, Liang., Chen, Yan., Yuan, Ling., Liu, Xuan., Gu, Jun-Fei., Zhang, Ming-Hua., Wang, Ying. A Combination of Alkaloids and Triterpenes of Alstonia scholaris (Linn.) R. Br. Leaves Enhances Immunomodulatory Activity in C57BL/6 Mice and Induces Apoptosis in the A549 Cell Line. MOLECULES, 2013, vol. 18, no. 11, p. 13920–13939. DOI: 10.3390/molecules181113920. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH (85%)
Substance:

indole alkaloids (RF-00004503-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

indole alkaloids

Endpoint study #1: Jong-Anurakkun, Nilubon., Bhandari, Megh Raj., Kawabata, Jun. alpha-Glucosidase inhibitors from Devil tree (Alstonia scholaris). FOOD CHEMISTRY, 2007, vol. 103, no. 4, p. 1319–1323. DOI: 10.1016/j.foodchem.2006.10.043. [DOI link]

Study relevance:

Human health
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water/methanol extract
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

3.5-56
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

alpha-glucosidase inhibition (51% sucrase, 74% maltase)
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition