EFSA Compendium of Botanicals

Draft - work in progress

Aerva lanata (L.) Juss.

Family:: Amaranthaceae
Approval state:: Approved
Number of articles retrieved:: 245
Number of processed references:: 5

Compositions

#1: Alkaloids (RF-00004360-PAR) #2: cardiac glycosides (cx000589) #3: Saponins (RF-00004333-PAR) #4: Quinones #5: Tannins (RF-00004337-PAR) #6: ervine #7: gallic acid #8: canthin-6-one (RF-00003726-PAR) #9: Carboline alkaloids (beta-carboline-1-propionic acid and derivatives)

Endpoint Studies

#1: Reproductive toxicity: pre-implantation loss of 20%; pregnancy failure was 30%

Genotoxicity

Composition #1: Vijayalakshmi, R., Ravindhran, R. Preliminary comparative phytochemical screening of root extracts of Diospyros ferrea (Wild.) Bakh and Aerva lanata (L.) Juss. ex Schultes.. Asian Journal of Plant Science and Research, 2012, vol. 2, no. 5, p. 581–587. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids (RF-00004360-PAR)

Composition #2: Vijayalakshmi, R., Ravindhran, R. Preliminary comparative phytochemical screening of root extracts of Diospyros ferrea (Wild.) Bakh and Aerva lanata (L.) Juss. ex Schultes.. Asian Journal of Plant Science and Research, 2012, vol. 2, no. 5, p. 581–587. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cardiac glycosides (cx000589)

Composition #3: Vijayalakshmi, R., Ravindhran, R. Preliminary comparative phytochemical screening of root extracts of Diospyros ferrea (Wild.) Bakh and Aerva lanata (L.) Juss. ex Schultes.. Asian Journal of Plant Science and Research, 2012, vol. 2, no. 5, p. 581–587. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins (RF-00004333-PAR)

Composition #4: Vijayalakshmi, R., Ravindhran, R. Preliminary comparative phytochemical screening of root extracts of Diospyros ferrea (Wild.) Bakh and Aerva lanata (L.) Juss. ex Schultes.. Asian Journal of Plant Science and Research, 2012, vol. 2, no. 5, p. 581–587. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Quinones (RF-00010832-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Quinones

Composition #5: Vijayalakshmi, R., Ravindhran, R. Preliminary comparative phytochemical screening of root extracts of Diospyros ferrea (Wild.) Bakh and Aerva lanata (L.) Juss. ex Schultes.. Asian Journal of Plant Science and Research, 2012, vol. 2, no. 5, p. 581–587. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins (RF-00004337-PAR)

Composition #6: Zapesochnaya, G.G., Kurkin, V.A., Okhanov, V.V., Perzykh, L.N., Miroshnilov, A.I. Structure of the alkaloids of Aerva lanata. chemistry of natural compounds, 1991, vol. 27, no. 6, p. 725–728. DOI: 10.1007/BF00629936. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

ervine (RF-00011125-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ervine

Composition #7: Vijayalakshmi, R., Ravindhran, R. HPTLC method for quantitative determination of gallic acid in ethanolic root extract of Diospyrus ferrea (Willd.) Bakh and Aerva lanata (L.) Juss. Ex Schultes -a potent indian medicinal plants. asian journal of pharmaceutical and clinical research, 2012, vol. 5, no. 4, p. 170–174. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Toluene-Ethyl acetate-Formic acid-Methanol (3: 3: 0.8: 0.2)
Substance:

gallic acid (RF-00003821-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

gallic acid

Composition #8: ZAPESOCHNAYA, G., KURKIN, V., OKHANOV, V., MIROSHNIKOV, A. CANTHIN-6-ONE AND BETA-CARBOLINE ALKALOIDS FROM AERVA-LANATA. PLANTA MEDICA, 1992, vol. 58, no. 2, p. 192–196. DOI: 10.1055/s-2006-961427. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

canthin-6-one (RF-00003726-PAR)
Additional substance description:

canthin-6-one and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

canthin-6-one (RF-00003726-PAR)

Composition #9: ZAPESOCHNAYA, G., KURKIN, V., OKHANOV, V., MIROSHNIKOV, A. CANTHIN-6-ONE AND BETA-CARBOLINE ALKALOIDS FROM AERVA-LANATA. PLANTA MEDICA, 1992, vol. 58, no. 2, p. 192–196. DOI: 10.1055/s-2006-961427. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

carboline alkaloids (RF-00004384-PAR)
Additional substance description:

beta-carboline-1-propionic acid and derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Carboline alkaloids (beta-carboline-1-propionic acid and derivatives)

Endpoint study #1: Savadi, R., Alagawadi, K. Antifertility activity of ethanolic extracts of plumbago indica and aerva lanata on albino rats. international journal of green pharmacy, 2009, vol. 3, no. 3, p. 230–233. DOI: 10.4103/0973-8258.56281. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanol extract (90% v/v)
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

7.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

6
Control groups used:

yes
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

200
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Uterus (TT052A)
Effect description:

pre-implantation loss of 20%; pregnancy failure was 30%
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Reproductive toxicity: pre-implantation loss of 20%; pregnancy failure was 30%