EFSA Compendium of Botanicals

Draft - work in progress

Adonis amurensis Regel & Radde

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 96
Number of processed references:: 9

Compositions

#1: Fukujusone (pregnane derivative) #2: Digitoxigenin #3: Strophantidin, K-strophantidin #4: cymarin/Abstract processing #5: Convallatoxin/Abstract processing #6: cardenolides in roots #7: Strophantidin/Abstract processed #8: convallatoxin/Abstract processed #9: convalloside/abstract processed #10: Somalin/abstract process #11: Digitoxigenin/Abstract process #12: Cymarin/Abstract process #13: Periplorhamnoside/Abstract processed #14: Pinoresinol/Abstract process #15: Amurensiosides (cardenolide glycosides) #16: Amurensiosides (cardenolide glucosides) #17: scopoletin #18: Umbelliferone

Endpoint Studies

Genotoxicity

Composition #1: Shimizu, Yuzuru., Sato, Yoshimasa., Mitsuhashi, Hiroshi. Isolation and structures of new pregnane derivatives from Adonis amurensis.. Chemical & Pharmaceutical Bulletin, 1969, vol. 17, no. 11, p. 2391–4. DOI: 10.1248/cpb.17.2391. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

pregnane derivatives (RF-00004313-PAR)
Additional substance description:

Fukujusone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

SIr, UV and Mass spectrometries
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Fukujusone (pregnane derivative)

Composition #2: Sato, Yoshimasa., Hirano, Miho., Nitta, Isao., Azuma, Junko., Hayashi, Koji., Mitsuhashi, Hiroshi. Components of adonis plants.. Chemical & Pharmaceutical Bulletin, 1971, vol. 19, no. 1, p. 202–5. DOI: 10.1248/cpb.19.202. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 70%
Substance:

digitoxigenin (RF-00004273-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

IR and UV spectroscopy
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Digitoxigenin

Composition #3: Sato, Yoshimasa., Hirano, Miho., Nitta, Isao., Azuma, Junko., Hayashi, Koji., Mitsuhashi, Hiroshi. Components of adonis plants.. Chemical & Pharmaceutical Bulletin, 1971, vol. 19, no. 1, p. 202–5. DOI: 10.1248/cpb.19.202. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH 70%
Substance:

strophantidin (RF-00004065-PAR)
Analytical method code:

Mass Spectroscopy and hyphenated methods without chromatography (F063A)
Analytical method - additional description:

UV and IR spectroscopy
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Strophantidin, K-strophantidin

Composition #4: Nakayama, Mutsuo., Yamamoto, Akihiro., Shinohara, Ayako., Fujita, Yoshihiko., Kanbara, Keizo., Miyataka, Hideki. Analysis of poisonous substances [cymarin] in Adonis amurensis Regel et Radde by LC/MS.. Japanese Journal of Forensic Toxicology, 2002, vol. 20, no. 1, p. 34–41. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

cymarin (RF-00003761-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cymarin/Abstract processing

Composition #5: Liu, Juan., Cui, Xiangwei. Determination of convallatoxin content in the herba of Adonis amurensis Regel et Radde by HPLC.. Zhongcaoyao, 2007, vol. 38, no. 4, p. 617–618. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

convallatoxin (RF-00003748-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0014-0.14
Internal remarks:

Convallatoxin/Abstract processing

Composition #6: Ponomarenko, A.A., Komissarenko, N.F., Stukkei, K.L. Cardenolides of Adonis amurensis. Chemistry of Natural Compounds, 1971, vol. 7, no. 6, p. 833–834. DOI: 10.1007/BF00567970. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform and ethanol (1:1)
Substance:

cardenolides (RF-00004389-PAR)
Additional substance description:

somalin, cymarin, cymarol, strophantidin, corchoroside A, convallotoxin, k-strophanthin-beta
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Analytical method - additional description:

Optical Rotation - Specific Rotation, melting point
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cardenolides in roots

Composition #7: Yin, L., Zhang, Y., Tian, H.-Y., Jiang, R.-W. Chemical constituents from Adonis amurensis. Chinese Traditional and Herbal Drugs, 2014, vol. 45, no. 23, p. 3361–3366. DOI: 10.7501/j.issn.0253-2670.2014.23.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Solvent: 95%/fractionation ethyl acetate/butanol
Substance:

strophantidin (RF-00004065-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Strophantidin/Abstract processed

Composition #8: Yin, L., Zhang, Y., Tian, H.-Y., Jiang, R.-W. Chemical constituents from Adonis amurensis. Chinese Traditional and Herbal Drugs, 2014, vol. 45, no. 23, p. 3361–3366. DOI: 10.7501/j.issn.0253-2670.2014.23.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Solvent: 95%/fractionation ethyl acetate/butanol
Substance:

convallatoxin (RF-00003748-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

convallatoxin/Abstract processed

Composition #9: Yin, L., Zhang, Y., Tian, H.-Y., Jiang, R.-W. Chemical constituents from Adonis amurensis. Chinese Traditional and Herbal Drugs, 2014, vol. 45, no. 23, p. 3361–3366. DOI: 10.7501/j.issn.0253-2670.2014.23.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Solvent: 95%/fractionation ethyl acetate/butanol
Substance:

convalloside (RF-00004213-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

convalloside/abstract processed

Composition #10: Yin, L., Zhang, Y., Tian, H.-Y., Jiang, R.-W. Chemical constituents from Adonis amurensis. Chinese Traditional and Herbal Drugs, 2014, vol. 45, no. 23, p. 3361–3366. DOI: 10.7501/j.issn.0253-2670.2014.23.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Solvent: 95%/fractionation ethyl acetate/butanol
Substance:

Somalin (RF-00011275-PAR)
Additional substance description:

somalin
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Somalin/abstract process

Composition #11: Yin, L., Zhang, Y., Tian, H.-Y., Jiang, R.-W. Chemical constituents from Adonis amurensis. Chinese Traditional and Herbal Drugs, 2014, vol. 45, no. 23, p. 3361–3366. DOI: 10.7501/j.issn.0253-2670.2014.23.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Solvent: 95%/fractionation ethyl acetate/butanol
Substance:

digitoxigenin (RF-00004273-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Digitoxigenin/Abstract process

Composition #12: Yin, L., Zhang, Y., Tian, H.-Y., Jiang, R.-W. Chemical constituents from Adonis amurensis. Chinese Traditional and Herbal Drugs, 2014, vol. 45, no. 23, p. 3361–3366. DOI: 10.7501/j.issn.0253-2670.2014.23.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Solvent: 95%/fractionation ethyl acetate/butanol
Substance:

cymarin (RF-00003761-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cymarin/Abstract process

Composition #13: Yin, L., Zhang, Y., Tian, H.-Y., Jiang, R.-W. Chemical constituents from Adonis amurensis. Chinese Traditional and Herbal Drugs, 2014, vol. 45, no. 23, p. 3361–3366. DOI: 10.7501/j.issn.0253-2670.2014.23.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Solvent: 95%/fractionation ethyl acetate/butanol
Substance:

Periplorhamnoside (RF-00011462-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Periplorhamnoside/Abstract processed

Composition #14: Yin, L., Zhang, Y., Tian, H.-Y., Jiang, R.-W. Chemical constituents from Adonis amurensis. Chinese Traditional and Herbal Drugs, 2014, vol. 45, no. 23, p. 3361–3366. DOI: 10.7501/j.issn.0253-2670.2014.23.001. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Solvent: 95%/fractionation ethyl acetate/butanol
Substance:

Pinoresinol (RF-00011088-PAR)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pinoresinol/Abstract process

Composition #15: Kuroda, Minpei., Kubo, Satoshi., Uchida, Shingo., Sakagami, Hiroshi., Mimaki, Yoshihiro. Amurensiosides A-K, 11 new pregnane glycosides from the roots of Adonis amurensis. STEROIDS, 2010, vol. 75, no. 1, p. 83–94. DOI: 10.1016/j.steroids.2009.10.008. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH
Substance:

cardenolide glycosides cardenolide glycosides (RF-00004348-PAR)
Additional substance description:

Amurensiosides
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Amurensiosides (cardenolide glycosides)

Composition #16: Kubo, Satoshi., Kuroda, Minpei., Yokosuka, Akihito., Sakagami, Hiroshi., Mimaki, Yoshihiro. Amurensiosides L-P, Five New Cardenolide Glycosides from the Roots of Adonis amurensis. NATURAL PRODUCT COMMUNICATIONS, 2015, vol. 10, no. 1, p. 27–32. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Additional extraction description:

unspecified
Substance:

cardenolide glycosides cardenolide glycosides (RF-00004348-PAR)
Additional substance description:

Amurensiosides
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Amurensiosides (cardenolide glucosides)

Composition #17: PONOMARE.AA., STUKKEI, KL., KOMISSAR.NF. COUMARINS OF ADONIS AMURENSIS. KHIMIYA PRIRODNYKH SOEDINENII, 1971, no. 5, p. 661–&. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

scopoletin (RF-00004048-PAR)
Analytical method - additional description:

IR and UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

scopoletin

Composition #18: PONOMARE.AA., STUKKEI, KL., KOMISSAR.NF. COUMARINS OF ADONIS AMURENSIS. KHIMIYA PRIRODNYKH SOEDINENII, 1971, no. 5, p. 661–&. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

umbelliferone (RF-00004096-PAR)
Analytical method - additional description:

IR and UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Umbelliferone