EFSA Compendium of Botanicals

Draft - work in progress

Adonis aestivalis L.

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 137
Number of processed references:: 5

Compositions

#1: Corytuberine #2: magnoflorine #3: Cardenolides #4: strophanthidin derivatives #5: cymarin #6: helveticoside #7: 3-epi-periplogenin

Endpoint Studies

#1: abdominal distension, generalized ileus, anorexia, decreased anal tone, edematous cecal mucosa strophanthidin #2: endocardial and epicardial hemorrhage, interstitial edema, myocarditis, myocardial collapse strophanthidin

Genotoxicity

Composition #1: Slavik, Jiri., Bochorakova, Jitka., Slavikova, Leonora. Occurrence of magnoflorine and corytuberine in some wild or cultivated plants of Czechoslovakia.. Collection of Czechoslovak Chemical Communications, 1987, vol. 52, no. 3, p. 804–11. DOI: 10.1135/cccc19870804. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Corytuberine (RF-00011231-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Value (concentration, content):

traces
Internal remarks:

Corytuberine

Composition #2: Slavik, Jiri., Bochorakova, Jitka., Slavikova, Leonora. Occurrence of magnoflorine and corytuberine in some wild or cultivated plants of Czechoslovakia.. Collection of Czechoslovak Chemical Communications, 1987, vol. 52, no. 3, p. 804–11. DOI: 10.1135/cccc19870804. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

magnoflorine (RF-00003919-PAR)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Value (concentration, content):

traces
Internal remarks:

magnoflorine

Composition #3: Kubo, Satoshi., Kuroda, Minpei., Matsuo, Yukiko., Masatani, Daichi., Sakagami, Hiroshi., Mimaki, Yoshihiro. New Cardenolides from the Seeds of Adonis aestivalis. CHEMICAL & PHARMACEUTICAL BULLETIN, 2012, vol. 60, no. 10, p. 1275–1282. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

cardenolides (RF-00004389-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardenolides

Composition #4: Kubo, Satoshi., Kuroda, Minpei., Matsuo, Yukiko., Masatani, Daichi., Sakagami, Hiroshi., Mimaki, Yoshihiro. New Cardenolides from the Seeds of Adonis aestivalis. CHEMICAL & PHARMACEUTICAL BULLETIN, 2012, vol. 60, no. 10, p. 1275–1282. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

strophantidin (RF-00004065-PAR)
Additional substance description:

strophanthidin derivatives
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

strophanthidin derivatives

Composition #5: KAVALALI, G. ISOLATION OF CYMARIN FROM ADONIS-AESTIVALIS. lloydia-the journal of natural products, 1973, vol. 36, no. 4, p. 426–426. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Additional extraction description:

solvent extraction ( ethanol), chloroform
Substance:

cymarin (RF-00003761-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cymarin

Composition #6: KOPP, B., KRENN, L., KUBELKA, E., KUBELKA, W. CARDENOLIDES FROM ADONIS-AESTIVALIS. PHYTOCHEMISTRY, 1992, vol. 31, no. 9, p. 3195–3198. DOI: 10.1016/0031-9422(92)83473-C. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

helveticoside (RF-00003861-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

helveticoside

Composition #7: KOPP, B., KRENN, L., KUBELKA, E., KUBELKA, W. CARDENOLIDES FROM ADONIS-AESTIVALIS. PHYTOCHEMISTRY, 1992, vol. 31, no. 9, p. 3195–3198. DOI: 10.1016/0031-9422(92)83473-C. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

periplogenin (RF-00003535-PAR)
Additional substance description:

3-epi-periplogenin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

3-epi-periplogenin

Endpoint study #1: Woods, LW., Filigenzi, MS., Booth, MC., Rodger, LD., Arnold, JS., Puschner, B. Summer pheasant's eye (Adonis aestivalis) poisoning in three horses. VETERINARY PATHOLOGY, 2004, vol. 41, no. 3, p. 215–220. DOI: 10.1354/vp.41-3-215. [DOI link]

Study relevance:

Animal (target species) health
Substance:

strophantidin (RF-00004065-PAR)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Additional plant/substance description:

HPLC-MS detection
Type of toxicological test:

case report (CHD060TT)
Limit test:

No data
Tested organism:

Horse (as animal) (A0B9Z)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

24.0
Unit of exposure duration:

Hour (G099A)
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

abdominal distension, generalized ileus, anorexia, decreased anal tone, edematous cecal mucosa
Effect or parameter linked to the endpoint:

clinical signs (CHD020BE)
Internal remarks:

abdominal distension, generalized ileus, anorexia, decreased anal tone, edematous cecal mucosa strophanthidin

Endpoint study #2: Woods, LW., Filigenzi, MS., Booth, MC., Rodger, LD., Arnold, JS., Puschner, B. Summer pheasant's eye (Adonis aestivalis) poisoning in three horses. VETERINARY PATHOLOGY, 2004, vol. 41, no. 3, p. 215–220. DOI: 10.1354/vp.41-3-215. [DOI link]

Study relevance:

Animal (target species) health
Substance:

strophantidin (RF-00004065-PAR)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Additional plant/substance description:

HPLC-MS detection
Type of toxicological test:

case report (CHD060TT)
Limit test:

No data
Tested organism:

Horse (as animal) (A0B9Z)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Exposure duration:

24.0
Unit of exposure duration:

Hour (G099A)
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

Cardiovascular / Haematological (TT001A)
Effect description:

endocardial and epicardial hemorrhage, interstitial edema, myocarditis, myocardial collapse
Effect or parameter linked to the endpoint:

clinical signs (CHD020BE)
Internal remarks:

endocardial and epicardial hemorrhage, interstitial edema, myocarditis, myocardial collapse strophanthidin