Actaea racemosa L. // Cimicifuga racemosa (L.) Nutt.

Family:
Ranunculaceae
Approval state:
Approved
Number of articles retrieved:
1551
Number of processed references:
8
Compositions
#1: triterpene glycosides (saponins) #2: alkaloids #3: tannins #4: protocatechuic acid #5: isoimperatorin and cimiside E (steroidal triterpene saponins)( #6: 23-O-acetylschengmanlo (coumarin)
Endpoint Studies
#1: Intragastric administration of doses of 2g/Kg from day 7 to 17 of gestation resulted to be teratogenic #2: autoimmune hepatitis #3: autoimmune hepatitis #4: myopathy with severe asthenia and rhabdomyolysis #5: reversible complete heart block with bradycardia #6: cutaneous pseudolymphoma, cutaneous vasculitis #7: carcinogenic (lungs) #8: liver damage
Genotoxicity
#1: Mouse lymphoma mutagencity #2: An alcoholic extract (40%) resulted to be mutagenic in S. typhimurium TA 98 an TA 100.
Composition #1: Abdualmjid, R.J., Sergi, C. Hepatotoxic botanicals - An evidence-based systematic review. journal of pharmacy and pharmaceutical sciences, 2013, vol. 16, no. 3, p. 376–404. .
Composition #2: Abdualmjid, R.J., Sergi, C. Hepatotoxic botanicals - An evidence-based systematic review. journal of pharmacy and pharmaceutical sciences, 2013, vol. 16, no. 3, p. 376–404. .
Composition #3: Abdualmjid, R.J., Sergi, C. Hepatotoxic botanicals - An evidence-based systematic review. journal of pharmacy and pharmaceutical sciences, 2013, vol. 16, no. 3, p. 376–404. .
Composition #4: Wang, Yun-Jan., Dou, Jinhui., Cross, Kevin P., Valerio, Luis G., Jr. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms . regulatory toxicology and pharmacology, 2011, vol. 59, no. 1, p. 111–124. DOI: 10.1016/j.yrtph.2010.09.012. [DOI link]
Composition #5: Moon, Lidiya., Ha, Yu Mi., Jang, Hwa Jin., Kim, Hee Sook., Jun, Min Soo., Kim, Young Min., Lee, Young Soo., Lee, Dong Hwa., Son, Kun Ho., Kim, Hye Jung., Seo, Han Geuk., Lee, Jae Heun., Kim, Yeong Shik., Chang, Ki Churl. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-alpha-induced VCAM-1 expression in human endothelial cells: Involvement of PPAR-gamma upregulation and PI3K, ERK1/2, and PKC signal pathways . journal of ethnopharmacology, 2011, vol. 133, no. 2, p. 336–344. DOI: 10.1016/j.jep.2010.10.004. [DOI link]
Composition #6: Moon, Lidiya., Ha, Yu Mi., Jang, Hwa Jin., Kim, Hee Sook., Jun, Min Soo., Kim, Young Min., Lee, Young Soo., Lee, Dong Hwa., Son, Kun Ho., Kim, Hye Jung., Seo, Han Geuk., Lee, Jae Heun., Kim, Yeong Shik., Chang, Ki Churl. Isoimperatorin, cimiside E and 23-O-acetylshengmanol-3-xyloside from Cimicifugae Rhizome inhibit TNF-alpha-induced VCAM-1 expression in human endothelial cells: Involvement of PPAR-gamma upregulation and PI3K, ERK1/2, and PKC signal pathways . journal of ethnopharmacology, 2011, vol. 133, no. 2, p. 336–344. DOI: 10.1016/j.jep.2010.10.004. [DOI link]
Endpoint study #1: Dos Reis Turolla, M.S., De Souza Nascimento, E. Toxicological information of some herbal medicines used in Brazil Informações toxicológicas de alguns fitoterápicos utilizados no Brasil . revista brasileira de ciencias farmaceuticas/brazilian journal of pharmaceutical sciences, 2006, vol. 42, no. 2, p. 289–306. .
Endpoint study #2: Seeff, L.B. Herbal Hepatotoxicity. clinics in liver disease, 2007, vol. 11, no. 3, p. 577–596. DOI: 10.1016/j.cld.2007.06.005. [DOI link]
Endpoint study #3: Abdualmjid, R.J., Sergi, C. Hepatotoxic botanicals - An evidence-based systematic review. journal of pharmacy and pharmaceutical sciences, 2013, vol. 16, no. 3, p. 376–404. .
Endpoint study #4: Di Lorenzo, C., Ceschi, A., Kupferschmidt, H., Lüde, S., De Souza Nascimento, E., Dos Santos, A., Colombo, F., Frigerio, G., Nørby, K., Plumb, J., Finglas, P., Restani, P. Adverse effects of plant food supplements and botanical preparations: A systematic review with critical evaluation of causality. british journal of clinical pharmacology, 2015, vol. 79, no. 4, p. 578–592. DOI: 10.1111/bcp.12519. [DOI link]
Endpoint study #5: Di Lorenzo, C., Ceschi, A., Kupferschmidt, H., Lüde, S., De Souza Nascimento, E., Dos Santos, A., Colombo, F., Frigerio, G., Nørby, K., Plumb, J., Finglas, P., Restani, P. Adverse effects of plant food supplements and botanical preparations: A systematic review with critical evaluation of causality. british journal of clinical pharmacology, 2015, vol. 79, no. 4, p. 578–592. DOI: 10.1111/bcp.12519. [DOI link]
Endpoint study #6: Di Lorenzo, C., Ceschi, A., Kupferschmidt, H., Lüde, S., De Souza Nascimento, E., Dos Santos, A., Colombo, F., Frigerio, G., Nørby, K., Plumb, J., Finglas, P., Restani, P. Adverse effects of plant food supplements and botanical preparations: A systematic review with critical evaluation of causality. british journal of clinical pharmacology, 2015, vol. 79, no. 4, p. 578–592. DOI: 10.1111/bcp.12519. [DOI link]
Endpoint study #7: Davis, Vicki L., Jayo, Manuel J., Ho, Arline., Kotlarczyk, Mary P., Hardy, Mary L., Foster, Warren G., Hughes, Claude L. Black Cohosh Increases Metastatic Mammary Cancer in Transgenic Mice Expressing c-erbB2 . cancer research, 2008, vol. 68, no. 20, p. 8377–8383. DOI: 10.1158/0008-5472.CAN-08-1812. [DOI link]
Endpoint study #8: Wang, Yun-Jan., Dou, Jinhui., Cross, Kevin P., Valerio, Luis G., Jr. Computational analysis for hepatic safety signals of constituents present in botanical extracts widely used by women in the United States for treatment of menopausal symptoms . regulatory toxicology and pharmacology, 2011, vol. 59, no. 1, p. 111–124. DOI: 10.1016/j.yrtph.2010.09.012. [DOI link]
Genotox #1: Seifried, H.E., Seifried, R.M., Clarke, J.J., Junghans, T.B., San, R.H.C. A compilation of two decades of mutagenicity test results with the ames Salmonella typhimurium and L5178Y mouse lymphoma cell mutation assays. chemical research in toxicology, 2006, vol. 19, no. 5, p. 627–644. DOI: 10.1021/tx0503552. [DOI link]
Genotox #2: Dos Reis Turolla, M.S., De Souza Nascimento, E. Toxicological information of some herbal medicines used in Brazil Informações toxicológicas de alguns fitoterápicos utilizados no Brasil . revista brasileira de ciencias farmaceuticas/brazilian journal of pharmaceutical sciences, 2006, vol. 42, no. 2, p. 289–306. .