EFSA Compendium of Botanicals

Draft - work in progress

Actaea cimicifuga L. // Cimicifuga foetida L.

Family:: Ranunculaceae
Approval state:: Approved
Number of articles retrieved:: 1541
Number of processed references:: 2

Compositions

#1: Pyridine alkaloids #2: cimipronidine #3: Dopargine #4: Lignans

Endpoint Studies

Genotoxicity

Composition #1: Godecke, Tanja., Lankin, David C., Nikolic, Dejan., Chen, Shao-Nong., van Breemen, Richard B., Farnsworth, Norman R., Pauli, Guido F. Guanidine Alkaloids and Pictet-Spengler Adducts from Black Cohosh (Cimicifuga racemosa).. Journal of Natural Products, 2009, vol. 72, no. 3, p. 433–437. DOI: 10.1021/np8006952. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

pyridine alkaloids (RF-00010801-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

1 and 2D NMR, LC-MS, HRMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pyridine alkaloids

Composition #2: Godecke, Tanja., Lankin, David C., Nikolic, Dejan., Chen, Shao-Nong., van Breemen, Richard B., Farnsworth, Norman R., Pauli, Guido F. Guanidine Alkaloids and Pictet-Spengler Adducts from Black Cohosh (Cimicifuga racemosa).. Journal of Natural Products, 2009, vol. 72, no. 3, p. 433–437. DOI: 10.1021/np8006952. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

cimipronidine (RF-00004208-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

1 and 2D NMR, LC-MS, HRMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cimipronidine

Composition #3: Godecke, Tanja., Lankin, David C., Nikolic, Dejan., Chen, Shao-Nong., van Breemen, Richard B., Farnsworth, Norman R., Pauli, Guido F. Guanidine Alkaloids and Pictet-Spengler Adducts from Black Cohosh (Cimicifuga racemosa).. Journal of Natural Products, 2009, vol. 72, no. 3, p. 433–437. DOI: 10.1021/np8006952. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

Dopargine (RF-00011291-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

1 and 2D NMR, LC-MS, HRMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Dopargine

Composition #4: Ulbricht, Catherine., Windsor, Regina C. An Evidence-Based Systematic Review of Black cohosh (Cimicifuga racemosa, Actaea racemosa) by the Natural Standard Research Collaboration. journal of dietary supplements, 2014 . .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Drying (dehydration) (A07KG)
Substance:

lignans (RF-00004361-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans