Genotox #1: Hassanane, M. M., Ahmed, E. S., Shoman, Th. M., Ezz-Eldin, A. Evaluation of the genotoxicity and antigenotoxicity of curcumin by chromosomal aberrations and biochemical studies in the albino rats exposed to methotrexate. global veterinaria, 2010, p. 185–189. .
Study category:
Genotoxicity
Type of toxicological test:
chromosome aberration assay (CHD047TT)
Method type:
in vivo
Tested organism:
Rat (as animal) (A0CNV)
Sex:
Male
Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration for in vivo:
37.0
Unit of exposure duration:
Day (G134A)
Number of organisms dosed:
80
Control groups used:
yes
Endpoint measured:
chromosome aberration
Is genotoxic:
Positive
Remarks on genotox study:
dose dependent significant increase in the frequencies of total chromosomal aberrations in bone marrow
Internal remarks:
chromosomal aberrations induced by curcumin higher doses
Internal ID:
CAPLUS_2010:480405
Genotox #2: Park, H.-J. Mutagenicity of the essential oils in Ames Test. korean journal of pharmacognosy, 2002, vol. 33, no. 4, p. 372–375. .
Study category:
Mutagenicity
Type of toxicological test:
bacterial gene mutation assay (CHD027TT)
Method type:
in vitro
Tested organism:
Salmonella typhimurium (as organism) (A0CPZ)
Strain of test organism:
TA 100 (CHD024ST)
Exogenous metabolic activation applied:
with
Endpoint measured:
gene mutation
Is genotoxic:
Positive
Remarks on genotox study:
Positive only after S9 activation (essential oil)
Internal remarks:
Esssential oil is mutagenic in Salmonella thyphymurium TA 100 in the presence of S9
