EFSA Compendium of Botanicals

Draft - work in progress

Artemisia herba-alba Asso

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 596
Number of processed references:: 9

Endpoint Studies

#1: Case report renal failure following 2 days aqueous extract A.herba alba twice daily

Genotoxicity

#1: positive micronucleus test #2: positive SCE test

Composition #1: Laid, Messai., Hegazy, Mohamed-Elamir F., Ahmed, Ahmed A., Ali, Kalla., Belkacemi, Djaballah., Ohta, Shinji. Sesquiterpene lactones from Algerian Artemisia herba-alba. PHYTOCHEMISTRY LETTERS, 2008, vol. 1, no. 2, p. 85–88. DOI: 10.1016/j.phytol.2008.04.002. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methynele chloride/methanol
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

1beta,9beta-Diacetoxyeudesm-3-en-5alpha,6beta,11betaH-12,6- olide; 1beta,9beta-Diacetoxyeudesm-4-en-6beta,11betaH-12,6-olide
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Analytical method - additional description:

NMR, DEPT, COSY, NOESY, HMQC, HMBC, HRMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sesquiterpene lactones

Composition #2: Mighri, Hedi., Akrout, Ahmed., Casanova, Joseph., Tomi, Felix., Neffati, Mohamed. Influence of Drying Time and Process on Artemisia herba-alba Asso Essential Oil Yield and Composition. JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2009, vol. 12, no. 3, p. 358–364. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GC, C NMR
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9
Internal remarks:

Camphor

Composition #3: Mighri, Hedi., Akrout, Ahmed., Casanova, Joseph., Tomi, Felix., Neffati, Mohamed. Influence of Drying Time and Process on Artemisia herba-alba Asso Essential Oil Yield and Composition. JOURNAL OF ESSENTIAL OIL BEARING PLANTS, 2009, vol. 12, no. 3, p. 358–364. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

Hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Analytical method - additional description:

GC, C NMR
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.4
Internal remarks:

1,8-cineole

Composition #4: Mighri, Hedi., Akrout, Ahmed., El-jeni, Hajer., Zaidi, Slah., Tomi, Felix., Casanova, Joseph., Neffati, Mohamed. Composition and Intraspecific Chemical Variability of the Essential Oil from Artemisia herba-alba Growing Wild in a Tunisian Arid Zone . chemistry & biodiversity, 2010, vol. 7, no. 11, p. 2709–2717. DOI: 10.1002/cbdv.201000054. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-FID (F040A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6-17
Internal remarks:

1,8-cineole (quantified)

Composition #5: Mighri, Hedi., Akrout, Ahmed., El-jeni, Hajer., Zaidi, Slah., Tomi, Felix., Casanova, Joseph., Neffati, Mohamed. Composition and Intraspecific Chemical Variability of the Essential Oil from Artemisia herba-alba Growing Wild in a Tunisian Arid Zone . chemistry & biodiversity, 2010, vol. 7, no. 11, p. 2709–2717. DOI: 10.1002/cbdv.201000054. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-FID (F040A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7-44
Internal remarks:

alpha-thujone (quantified)

Composition #6: Mighri, Hedi., Akrout, Ahmed., El-jeni, Hajer., Zaidi, Slah., Tomi, Felix., Casanova, Joseph., Neffati, Mohamed. Composition and Intraspecific Chemical Variability of the Essential Oil from Artemisia herba-alba Growing Wild in a Tunisian Arid Zone . chemistry & biodiversity, 2010, vol. 7, no. 11, p. 2709–2717. DOI: 10.1002/cbdv.201000054. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

beta-thujone (RF-00003712-PAR)
Analytical method code:

GC-FID (F040A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

17-58
Internal remarks:

beta-thujone (quantified)

Composition #7: Mighri, Hedi., Akrout, Ahmed., El-jeni, Hajer., Zaidi, Slah., Tomi, Felix., Casanova, Joseph., Neffati, Mohamed. Composition and Intraspecific Chemical Variability of the Essential Oil from Artemisia herba-alba Growing Wild in a Tunisian Arid Zone . chemistry & biodiversity, 2010, vol. 7, no. 11, p. 2709–2717. DOI: 10.1002/cbdv.201000054. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-FID (F040A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4-11
Internal remarks:

camphor (quantified)

Composition #8: Tilaki, Ghasem Ali Dianati., Gholami, Farzaneh., Behtari, Behzad., Bezdi, Kamal Ghasemi. CHEMICAL COMPOSITION AND ALLELOPATHIC EFFECT OF THE ESSENTIAL OIL OF ARTEMISIA HERBA-ALBA ASSO. ON SEED GERMINATION AND EARLY SEEDLING GROWTH OF LEGUMES AND GRASSES SPECIES . legume research, 2013, vol. 36, no. 1, p. 33–40. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

artemisia ketone (RF-00004157-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

13
Internal remarks:

artemisia ketone (quantified)

Composition #9: Tilaki, Ghasem Ali Dianati., Gholami, Farzaneh., Behtari, Behzad., Bezdi, Kamal Ghasemi. CHEMICAL COMPOSITION AND ALLELOPATHIC EFFECT OF THE ESSENTIAL OIL OF ARTEMISIA HERBA-ALBA ASSO. ON SEED GERMINATION AND EARLY SEEDLING GROWTH OF LEGUMES AND GRASSES SPECIES . legume research, 2013, vol. 36, no. 1, p. 33–40. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8
Internal remarks:

1,8-cineole (quantified)

Composition #10: Belhattab, Rachid., Amor, Loubna., Barroso, Jose G., Pedro, Luis G., Figueiredo, A. Cristina. Essential oil from Artemisia herba-alba Asso grown wild in Algeria: Variability assessment and comparison with an updated literature survey . arabian journal of chemistry, 2014, vol. 7, no. 2, p. 243–251. DOI: 10.1016/j.arabjc.2012.04.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

17.3-33.1
Internal remarks:

camphor (quantified)

Composition #11: Belhattab, Rachid., Amor, Loubna., Barroso, Jose G., Pedro, Luis G., Figueiredo, A. Cristina. Essential oil from Artemisia herba-alba Asso grown wild in Algeria: Variability assessment and comparison with an updated literature survey . arabian journal of chemistry, 2014, vol. 7, no. 2, p. 243–251. DOI: 10.1016/j.arabjc.2012.04.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

beta-thujone (RF-00003712-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.9-7.8
Internal remarks:

beta-thujone (quantified)

Composition #12: Belhattab, Rachid., Amor, Loubna., Barroso, Jose G., Pedro, Luis G., Figueiredo, A. Cristina. Essential oil from Artemisia herba-alba Asso grown wild in Algeria: Variability assessment and comparison with an updated literature survey . arabian journal of chemistry, 2014, vol. 7, no. 2, p. 243–251. DOI: 10.1016/j.arabjc.2012.04.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.9-28.1
Internal remarks:

alpha-thujone (quantified)

Composition #13: Belhattab, Rachid., Amor, Loubna., Barroso, Jose G., Pedro, Luis G., Figueiredo, A. Cristina. Essential oil from Artemisia herba-alba Asso grown wild in Algeria: Variability assessment and comparison with an updated literature survey . arabian journal of chemistry, 2014, vol. 7, no. 2, p. 243–251. DOI: 10.1016/j.arabjc.2012.04.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.0-9.8
Internal remarks:

1,8-cineole (quantified)

Composition #14: Aouadi, D., Zorghi, L., Neffati, M., Ben Salem, H. The evaluation of the nutritional potential of five Mediterranean woody plants rich in phytocompounds . journal of animal and feed sciences, 2015, vol. 24, no. 2, p. 160–165. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

7.88
Internal remarks:

1,8-cineole (quantitative)

Composition #15: Aouadi, D., Zorghi, L., Neffati, M., Ben Salem, H. The evaluation of the nutritional potential of five Mediterranean woody plants rich in phytocompounds . journal of animal and feed sciences, 2015, vol. 24, no. 2, p. 160–165. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

beta-thujone (RF-00003712-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.70
Internal remarks:

beta-thujone (quantitative)

Composition #16: Aouadi, D., Zorghi, L., Neffati, M., Ben Salem, H. The evaluation of the nutritional potential of five Mediterranean woody plants rich in phytocompounds . journal of animal and feed sciences, 2015, vol. 24, no. 2, p. 160–165. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.42
Internal remarks:

alpha-thujone (quantitative)

Composition #17: Aouadi, D., Zorghi, L., Neffati, M., Ben Salem, H. The evaluation of the nutritional potential of five Mediterranean woody plants rich in phytocompounds . journal of animal and feed sciences, 2015, vol. 24, no. 2, p. 160–165. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

16.99
Internal remarks:

camphor (quantitative)

Composition #18: Dahmani-Hamzaoui, Nacera., Baaliouamer, Aoumeur. Volatile constituents of Algerian Artemisia herba-alba essential oils. journal of essential oil research, 2015, vol. 27, no. 5, p. 437–446. DOI: 10.1080/10412905.2015.1027418. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

5.6-30.0
Internal remarks:

camphor (quantitative)

Composition #19: Dahmani-Hamzaoui, Nacera., Baaliouamer, Aoumeur. Volatile constituents of Algerian Artemisia herba-alba essential oils. journal of essential oil research, 2015, vol. 27, no. 5, p. 437–446. DOI: 10.1080/10412905.2015.1027418. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.1-11.4
Internal remarks:

1,8-cineole (quantitative)

Composition #20: Dahmani-Hamzaoui, Nacera., Baaliouamer, Aoumeur. Volatile constituents of Algerian Artemisia herba-alba essential oils. journal of essential oil research, 2015, vol. 27, no. 5, p. 437–446. DOI: 10.1080/10412905.2015.1027418. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

alpha-thujone (RF-00003676-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

9.2-47.1
Internal remarks:

alpha-thujone (quantitative)

Composition #21: Dahmani-Hamzaoui, Nacera., Baaliouamer, Aoumeur. Volatile constituents of Algerian Artemisia herba-alba essential oils. journal of essential oil research, 2015, vol. 27, no. 5, p. 437–446. DOI: 10.1080/10412905.2015.1027418. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Substance:

beta-thujone (RF-00003712-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result expression:

Whole weight (B001A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.0-9.2
Internal remarks:

beta-thujone (quantitative)

Endpoint study #1: Aloui, Sabra., Skhiri, Hbib., Ltaief, Ahmed., Elmay, Mezri. An exceptional case of acute renal failure: is there a renal toxicity of Artemisia herba-alba? . renal failure, 2010, vol. 32, no. 8, p. 1009–1011. DOI: 10.3109/0886022X.2010.501932. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

aqueous extract
Type of toxicological test:

case report (CHD060TT)
Limit test:

Not applicable
Tested organism:

Human (as organism) (A056J)
Sex:

Male
Exposure duration:

2.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

1
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

renal failure following 2 days aqueous extract A.herba alba twice daily
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Case report renal failure following 2 days aqueous extract A.herba alba twice daily

Genotox #1: Abderrahman, Salim M., Shbailat, Seba Jamal. Genotoxic and cytotoxic effects of Artemisia herba-alba on mammalian cells. CARYOLOGIA, 2014, vol. 67, no. 4, p. 265–272. DOI: 10.1080/0144235X.2014.974355. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

micronucleus assay (CHD051TT)
Method type:

in vivo
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

No data
Route of exposure:

OTHER (OECD0PL)
Exposure duration for in vivo:

72.0
Unit of exposure duration:

Hour (G099A)
Number of organisms dosed:

70
Control groups used:

yes
Endpoint measured:

chromosome aberration
Is genotoxic:

Positive
Remarks on genotox study:

ethanolic extract from the leaves gave positive micronucleus test bone marrow, however some cytotoxicity observed
Internal remarks:

positive micronucleus test
Internal ID:

WOS:000346265300001

Genotox #2: Abderrahman, Salim M., Shbailat, Seba Jamal. Genotoxic and cytotoxic effects of Artemisia herba-alba on mammalian cells. CARYOLOGIA, 2014, vol. 67, no. 4, p. 265–272. DOI: 10.1080/0144235X.2014.974355. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

sister chromatid exchange assay in mammalian cells (CHD039TT)
Method type:

in vivo
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

No data
Route of exposure:

OTHER (OECD0PL)
Exposure duration for in vivo:

72.0
Unit of exposure duration:

Hour (G099A)
Number of organisms dosed:

60
Control groups used:

yes
Endpoint measured:

genome mutation
Is genotoxic:

Positive
Remarks on genotox study:

ethanolic extract from the leaves gave positive SCE test, however some cytotoxicity observed
Internal remarks:

positive SCE test
Internal ID:

WOS:000346265300001