EFSA Compendium of Botanicals

Draft - work in progress

Sternbergia colchiciflora Waldst. & Kit.

Family:: Amaryllidaceae
Approval state:: Approved
Number of articles retrieved:: 2
Number of processed references:: 2

Compositions

#1: Amaryllidaceae alkaloids in bulbs #2: Galanthamine in bulbs #3: Anhydrolycorine in whole plant #4: Hordenine in roots #5: Ismine in whole plant #6: Trisphaeridine in whole plant #7: 8-O-Demethylmaritidine in leaves #8: Vittatine and derivatives in whole plant #9: Lycorine and derivatives in whole plant #10: Tazettine and derivatives in whole plant #11: Haemanthamine in whole plant #12: Haemanthidine in whole plant #13: 3-Epimacronine in leaves #14: Pseudolycorine in whole plant #15: Alkaloids in whole plant

Endpoint Studies

Genotoxicity

Composition #1: Kintsurashvili, L., Vachnadze, V. Plants of the Amaryllidaceae family grown and introduced in Georgia: A source of galanthamine. pharmaceutical chemistry journal, 2007, vol. 41, no. 9, p. 492–494. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

amaryllidaceae alkaloids: lycorine; gemanthamine; tazettine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Amaryllidaceae alkaloids in bulbs

Composition #2: Kintsurashvili, L., Vachnadze, V. Plants of the Amaryllidaceae family grown and introduced in Georgia: A source of galanthamine. pharmaceutical chemistry journal, 2007, vol. 41, no. 9, p. 492–494. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

galanthamine (RF-00003399-PAR)
Analytical method code:

Gelpermeation, High Performance Thin Layer Chromatography (HPTLC) (F017A)
Analytical method - additional description:

TLC
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.01-0.07
Internal remarks:

Galanthamine in bulbs

Composition #3: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Anhydrolycorine (RF-00013325-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.5-45.2
Internal remarks:

Anhydrolycorine in whole plant

Composition #4: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

hordenine (RF-00003427-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1
Internal remarks:

Hordenine in roots

Composition #5: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

ismine (RF-00003439-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1-0.9
Internal remarks:

Ismine in whole plant

Composition #6: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Trisphaeridine
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3-11.8
Internal remarks:

Trisphaeridine in whole plant

Composition #7: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Normaritidine (RF-00013324-PAR)
Additional substance description:

syn 8-O-Demethylmaritidine
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.4
Internal remarks:

8-O-Demethylmaritidine in leaves

Composition #8: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Vittatine (RF-00013326-PAR)
Additional substance description:

Vittatine and derivatives: 11-Hydroxyvittatine
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3-72.1
Internal remarks:

Vittatine and derivatives in whole plant

Composition #9: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

lycorine (RF-00003913-PAR)
Additional substance description:

Lycorine and derivatives: 2,11-Didehydro-2-dehydroxylycorine; 11,12-Didehydroanhydrolycorine
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.7-85.4
Internal remarks:

Lycorine and derivatives in whole plant

Composition #10: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

tazettine (RF-00003599-PAR)
Additional substance description:

Tazettine and derivatives: 11-Deoxytazettine
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.2-22.1
Internal remarks:

Tazettine and derivatives in whole plant

Composition #11: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

haemanthamine (RF-00003414-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.6-6.3
Internal remarks:

Haemanthamine in whole plant

Composition #12: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Haemanthidine
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

4.2-5.5
Internal remarks:

Haemanthidine in whole plant

Composition #13: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

3-Epimacronine
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.3
Internal remarks:

3-Epimacronine in leaves

Composition #14: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

pseudolycorine (RF-00003559-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.1-0.5
Internal remarks:

Pseudolycorine in whole plant

Composition #15: Berkov, Strahil., Bastida, Jaume., Tsvetkova, Reneta., Viladomat, Francesc., Codina, Carles. Alkaloids from Sternbergia colchiciflora. zeitschrift fur naturforschung section c-a journal of biosciences, 2009, vol. 64, no. 5-6, p. 311–316. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 95%
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

Tyramine; Methyltyramine; Hamayne; Ungiminorine; Ungeremine
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in whole plant