Composition #1: Powell, R.G., Smith Jr., C.R., Weisleder, D. Sesbanimide A and related tumor inhibitors from Sesbania drummondii: Structure and chemistry. phytochemistry, 1984, vol. 23, no. 12, p. 2789–2796. DOI: 10.1016/0031-9422(84)83017-4.
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DOI link]
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Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol
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Substance:
Sesbanimide A (RF-00003657-PAR)
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Additional substance description:
Sesbanimide A-C alkaloids
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Sesbanimide A-C in seeds alkaloid
Endpoint study
#1: Venugopalan, C.S., Flory, W., Tucker, T.A., Hebert, C.D., Strain, G.M. Assessment of smooth muscle function in Sesbania drummondii toxicosis in Gallus domesticus.. american journal of veterinary research, 1984, vol. 45, no. 4, p. 764–768. .
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Study relevance:
Animal (target species) health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
sodium bicarbonate
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Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Gallus gallus (chicken) (as animal) (A057Z)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
14
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Percent (G138A)
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Effect concentration:
0.5-0.25
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Critical effect:
Digestive (TOX18A)
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Target tissue:
respiratory: Lung (TT041A)
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Effect description:
Depresion of smooth muscles in lung and intestine, inflammation of proventriculus, body weight loss (for the higher dose)
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Effect or parameter linked to the endpoint:
gross pathology (CHD022BE)
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Internal remarks:
Depression of smooth muscles
