EFSA Compendium of Botanicals

Draft - work in progress

Schefflera barteri (Seem.) Harms // Astropanax barteri Seem.

Family:: Araliaceae
Approval state:: Approved
Number of articles retrieved:: 1
Number of processed references:: 1

Compositions

#1: Saponins in bark #2: Anthraquinones in bark

Endpoint Studies

#1: Neurotoxicity and decrease in food consumption (acute toxicity in mice) #2: Systemic toxicity (short-term toxicity in rats)

Genotoxicity

Composition #1: Atsafack Serge Secco., Kuiate Jules-Roger., De Dieu Tamokou Jean., Magnifouet Nana Huguette., Mouokeu Raymond Simplice., Koanga Mogtomo Martin Luther., Ebelle Etame Rebecca Madeleine., Ngono Ngane Rosalie Annie., Tchinda Alembert Tiabou., Biyiti Lucie. Toxicological studies of stem bark extract from Schefflera barteri Harms (Araliaceae). bmc complementary and alternative medicine, 2015, vol. 15, p. 44. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

maceration in methylene chloride/methanol (1:1) for 48 hr
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in bark

Composition #2: Atsafack Serge Secco., Kuiate Jules-Roger., De Dieu Tamokou Jean., Magnifouet Nana Huguette., Mouokeu Raymond Simplice., Koanga Mogtomo Martin Luther., Ebelle Etame Rebecca Madeleine., Ngono Ngane Rosalie Annie., Tchinda Alembert Tiabou., Biyiti Lucie. Toxicological studies of stem bark extract from Schefflera barteri Harms (Araliaceae). bmc complementary and alternative medicine, 2015, vol. 15, p. 44. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

maceration in methylene chloride/methanol (1:1) for 48 hr
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones in bark

Endpoint study #1: Atsafack Serge Secco., Kuiate Jules-Roger., De Dieu Tamokou Jean., Magnifouet Nana Huguette., Mouokeu Raymond Simplice., Koanga Mogtomo Martin Luther., Ebelle Etame Rebecca Madeleine., Ngono Ngane Rosalie Annie., Tchinda Alembert Tiabou., Biyiti Lucie. Toxicological studies of stem bark extract from Schefflera barteri Harms (Araliaceae). bmc complementary and alternative medicine, 2015, vol. 15, p. 44. .

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

maceration in methylene chloride/methanol (1:1) for 48 hr
Type of toxicological test:

acute toxicity (CHD016TT)
Tested organism:

House mouse (as animal) (A0CNT)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male/Female
Exposure duration:

1.0
Unit of exposure duration:

Meal (G109A)
Number of organisms dosed:

40
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

2000-16000
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

Reduction of locomotion, reaction to noise and reaction to pinch; Reduction of food consumption was noticed for all treated mice; at doses of 8000 and 16000 mg/kg showed a reduction in body weight
Effect or parameter linked to the endpoint:

food consumption (CHD007BE)
Internal remarks:

Neurotoxicity and decrease in food consumption (acute toxicity in mice)

Endpoint study #2: Atsafack Serge Secco., Kuiate Jules-Roger., De Dieu Tamokou Jean., Magnifouet Nana Huguette., Mouokeu Raymond Simplice., Koanga Mogtomo Martin Luther., Ebelle Etame Rebecca Madeleine., Ngono Ngane Rosalie Annie., Tchinda Alembert Tiabou., Biyiti Lucie. Toxicological studies of stem bark extract from Schefflera barteri Harms (Araliaceae). bmc complementary and alternative medicine, 2015, vol. 15, p. 44. .

Study relevance:

Human health
Plant part:

Bark (as part-nature) (A066X)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

maceration in methylene chloride/methanol (1:1) for 48 hr
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Swiss (CHD005ST)
Sex:

Male/Female
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

40
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

100-800
Critical effect:

SYSTEMIC (TOX01A)
Effect description:

Reduction in body weight and food consumtion in female; organ weight changes in both sexes; Haematological and biochemical parameters changed; Histopathological changes in liver, lungs, testis and kidneys
Effect or parameter linked to the endpoint:

histopathology neoplastic (CHD024BE)
Internal remarks:

Systemic toxicity (short-term toxicity in rats)