EFSA Compendium of Botanicals

Draft - work in progress

Heptapleurum leucanthum (R.Vig.) Y.F.Deng // Schefflera kwangsiensis Merr. ex H.L.Li // Schefflera leucantha R.Vig

Family:: Araliaceae
Approval state:: Approved
Number of articles retrieved:: 2
Number of processed references:: 2

Compositions

Endpoint Studies

#1: Increase of liver weight of male rats #2: Decrease of testis and lung weight of male rats

Genotoxicity

Composition #1: Wang, Cun-Qin., Wang, Ying., Wang, Wen-Jing., Wang, Lei., Ye, Wen-Cai. New oleanane saponins from Schefflera kwangsiensis. phytochemistry letters, 2014, vol. 10, p. 268–271. DOI: 10.1016/j.phytol.2014.10.010. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Triterpene saponins Triterpene saponins (RF-00004338-PAR)
Additional substance description:

schefflesides I–L
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

schefflesides I–L in aerial parts

Endpoint study #1: Witthawaskul, P., Panthong, A., Kanjanapothi, D., Taesothikul, T., Lertprasertsuke, N. Acute and subacute toxicities of the saponin mixture isolated from Schefflera leucantha Viguier . journal of ethnopharmacology, 2003, vol. 89, no. 1, p. 115–121. DOI: 10.1016/S0378-8741(03)00273-3. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

n-butanol
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

12
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

1000
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Increase of liver weight of male rats
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

Increase of liver weight of male rats

Endpoint study #2: Witthawaskul, P., Panthong, A., Kanjanapothi, D., Taesothikul, T., Lertprasertsuke, N. Acute and subacute toxicities of the saponin mixture isolated from Schefflera leucantha Viguier . journal of ethnopharmacology, 2003, vol. 89, no. 1, p. 115–121. DOI: 10.1016/S0378-8741(03)00273-3. [DOI link]

Study relevance:

Human health
Substance:

Saponins (RF-00004333-PAR)
Plant part:

Leaves (as part-nature) (A0EKT)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

n-butanol
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Sprague-Dawley (CHD012ST)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

12
Control groups used:

yes
Endpoint measured:

Concentration level (CHD013EP)
Concentration unit:

Milligrams per kilogram body weight (G225A)
Effect concentration:

1000
Critical effect:

PULMONARY AND CARDIAC (TOX08A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

Decrease of testis and lung weight of male rats
Effect or parameter linked to the endpoint:

organ weights (CHD012BE)
Internal remarks:

Decrease of testis and lung weight of male rats