EFSA Compendium of Botanicals

Draft - work in progress

Lyonia ovalifolia var. elliptica (Siebold & Zucc.) Hand.-Mazz.

Family:: Ericaceae
Approval state:: Approved
Number of articles retrieved:: 5
Number of processed references:: 5

Compositions

#1: Lyoniol A #2: Lignans in branches and trunks #3: Lignans (ovafolinins A—E; lyoniside and lyoniresinol) in woods #4: Lyoniol A-C in leaves #5: Diterpenes (Lyoniol A and B) in leaves

Endpoint Studies

Genotoxicity

Composition #1: Yasue, Masaiti., Kato, Takeshi., Sakakibara, Jinsaku. Structure of lyoniol-A (lyoniatoxin). chemical & pharmaceutical bulletin, 1970, vol. 18, no. 4, p. 854–6. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

Lyoniol A
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lyoniol A

Composition #2: Rahman, Md. Atiar., Katayama, Takeshi., Suzuki, Toshisada., Nakagawa, Takashi. Stereochemistry and biosynthesis of (+)-lyoniresinol, a syringyl tetrahydronaphthalene lignan in Lyonia ovalifolia var. elliptica I: isolation and stereochemistry of syringyl lignans and predicted precursors to (+)-lyoniresinol from wood . journal of wood science, 2007, vol. 53, no. 2, p. 161–167. DOI: 10.1007/s10086-006-0832-1. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol; extracted from branches and trunks
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

syringyl lignans: Syringaresinol; Lyoniresinol; (±)-5,5′-Dimethoxylariciresinol and (±)-5,5′-dimethoxysecoisolariciresinol.
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

EI-MS; HPLC, TLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans in branches and trunks

Composition #3: Kashima, Kenji., Sano, Kaichi., Yun, Young Sook., Ina, Hiroji., Kunugi, Akira., Inoue, Hideshi. Ovafolinins A-E, Five New Lignans from Lyonia ovalifolia. chemical & pharmaceutical bulletin, 2010, vol. 58, no. 2, p. 191–194. .

Language:

English (en)
Plant part:

Wood (as part-nature) (A166P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

ovafolinins A—E; lyoniside and lyoniresinol
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

HPLC+TLC+NMR+MS+UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lignans (ovafolinins A—E; lyoniside and lyoniresinol) in woods

Composition #4: YASUE, M., OTA, H., KISHIDA, T., KATO, Y. ISOLATION OF LYONIOL-A, -B, AND -C, TOXIC PRINCIPLES OF LYONIA OVALIFOLIA VAR ELLIPTICA . chemical & pharmaceutical bulletin, 1961, vol. 9, no. 2, p. 171–+. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

Lyoniol A-C
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Analytical method - additional description:

IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lyoniol A-C in leaves

Composition #5: HOTTA, Y., TAKEYA, K., KOBAYASHI, S., HARADA, N., SAKAKIBARA, J., SHIRAI, N. RELATIONSHIP BETWEEN STRUCTURE, POSITIVE INOTROPIC POTENCY AND LETHAL DOSE OF GRAYANOTOXINS IN GUINEA-PIG . archives of toxicology, 1980, vol. 44, no. 4, p. 259–267. DOI: 10.1007/BF00278033. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Additional extraction description:

unspecified
Substance:

Diterpenes Diterpenes (RF-00004378-PAR)
Additional substance description:

Lyoniol A and B
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Diterpenes (Lyoniol A and B) in leaves