EFSA Compendium of Botanicals

Draft - work in progress

Grewia nervosa (Lour.) Panigrahi

Family:: Malvaceae
Approval state:: Approved
Number of articles retrieved:: 1
Number of processed references:: 1

Compositions

#1: Pipridine alkaloids (Microgrewiapine A; homomicrogrewiapine and N-methyl-microcosaminie) in roots

Endpoint Studies

Genotoxicity

Composition #1: Meena, Surya N., Majik, Mahesh S., Ghadi, Sanjeev C., Tilve, Santosh G. Quick identification of piperidine alkaloid from roots of Grewia nervosa and their glucosidase inhibitory activity. . chemistry & biodiversity, 2017 . DOI: 10.1002/cbdv.201700400. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-butanol
Substance:

Piperidine alkaloids (RF-00004320-PAR)
Additional substance description:

Microgrewiapine A; homomicrogrewiapine and N-methyl-microcosaminie
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-NMR-IR_LC-HRMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pipridine alkaloids (Microgrewiapine A; homomicrogrewiapine and N-methyl-microcosaminie) in roots

Endpoint study #1: Meena, Surya N., Majik, Mahesh S., Ghadi, Sanjeev C., Tilve, Santosh G. Quick identification of piperidine alkaloid from roots of Grewia nervosa and their glucosidase inhibitory activity. . chemistry & biodiversity, 2017 . DOI: 10.1002/cbdv.201700400. [DOI link]

Study relevance:

Human health
Substance:

Piperidine alkaloids (RF-00004320-PAR)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

n-butanol
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

0.0535
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

alpha-glucosidase inhibition
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

alpha-glucosidase inhibition