Endpoint study
#1: Oliveira, Diego M., Pimentel, Luciano A., Araujo, Jose A. S., Medeiros, Rosane M. T., Dantas, Antonio F. M., Riet-Correa, Franklin. Poisoning by Cnidoscolus phyllacanthus (Euphorbiaceae) in goats. pesquisa veterinaria brasileira, 2008, vol. 28, no. 1, p. 36–42. .
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Study relevance:
Animal (target species) health
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Substance:
Cyanogenic glycosides (RF-00004375-PAR)
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Plant part:
Leaves (as part-nature) (A0EKT)
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Preparation/Extraction method:
Fresh (A166Y)
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Additional plant/substance description:
Dried and fresh leaves
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Type of toxicological test:
other (CHD008TT)
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Limit test:
Not applicable
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Tested organism:
Goat (as animal) (A057P)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Number of organisms dosed:
8
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Control groups used:
no data
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Endpoint measured:
Concentration level (CHD013EP)
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Concentration unit:
Gram/kilogram (G015A)
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Critical effect:
PULMONARY AND CARDIAC (TOX08A)
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Target tissue:
Respiratory (TT005A)
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Effect description:
Tachycardia, tachypnoea, dyspnoea, nystagmus, opisthotonos and sternal recumbence. Death
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
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Internal remarks:
Tachycardia, tachypnoea, dyspnoea, nystagmus, opisthotonos, sternal recumbence and death of goats by fresh leaves of Cnidoscolus phyllacanthus (syn. of Cnidoscolus quercifolius)
