EFSA Compendium of Botanicals

Draft - work in progress

Amaryllis belladonna L.

Family:: Amaryllidaceae
Approval state:: Approved
Number of articles retrieved:: 4
Number of processed references:: 4

Compositions

#1: belladine in bulbs #2: Galanthamine in bulbs #3: Tetrahydroisoquinoline alkaloids (Acetylcaranine, Anhydrolycorinium, Anhydrolycorin-6-one, Crinine, Undulatine, Buphanidrine, Buphanisine) #4: Pratorimine #5: Lycorine #6: Ambelline #7: Caranine #8: Isoquinoline alkaloids in bulbs

Endpoint Studies

Genotoxicity

Composition #1: Warnhoff, E. W. Belladine: a novel amaryllidaceae alkaloid. chemistry & industry (london, united kingdom), 1957, p. 1385–6. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

belladine
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

belladine in bulbs

Composition #2: Cherkasov, O. A. Plant sources of galanthamine. khimiko-farmatsevticheskii zhurnal, 1977, vol. 11, no. 6, p. 84–7. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

galanthamine (RF-00003399-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Galanthamine in bulbs

Composition #3: Nair, Jerald J., van Staden, Johannes. Pharmacological and toxicological insights to the South African Amaryllidaceae . food and chemical toxicology, 2013, vol. 62, p. 262–275. DOI: 10.1016/j.fct.2013.08.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

Tetrahydroisoquinoline alkaloids (Acetylcaranine, Anhydrolycorinium, Anhydrolycorin-6-one, Crinine, Undulatine, Buphanidrine, Buphanisine)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tetrahydroisoquinoline alkaloids (Acetylcaranine, Anhydrolycorinium, Anhydrolycorin-6-one, Crinine, Undulatine, Buphanidrine, Buphanisine)

Composition #4: Nair, Jerald J., van Staden, Johannes. Pharmacological and toxicological insights to the South African Amaryllidaceae . food and chemical toxicology, 2013, vol. 62, p. 262–275. DOI: 10.1016/j.fct.2013.08.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

pratorimine (RF-00003551-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Pratorimine

Composition #5: Nair, Jerald J., van Staden, Johannes. Pharmacological and toxicological insights to the South African Amaryllidaceae . food and chemical toxicology, 2013, vol. 62, p. 262–275. DOI: 10.1016/j.fct.2013.08.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

lycorine (RF-00003913-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Lycorine

Composition #6: Nair, Jerald J., van Staden, Johannes. Pharmacological and toxicological insights to the South African Amaryllidaceae . food and chemical toxicology, 2013, vol. 62, p. 262–275. DOI: 10.1016/j.fct.2013.08.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

ambelline (RF-00004141-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Ambelline

Composition #7: Nair, Jerald J., van Staden, Johannes. Pharmacological and toxicological insights to the South African Amaryllidaceae . food and chemical toxicology, 2013, vol. 62, p. 262–275. DOI: 10.1016/j.fct.2013.08.042. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

caranine (RF-00004193-PAR)
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Caranine

Composition #8: Queckenberg, OR., Frahm, AW., MullerDoblies, D., MullerDoblies, U. Reinvestigation of Amaryllis belladonna. phytochemical analysis, 1996, vol. 7, no. 3, p. 156–160. .

Language:

English (en)
Plant part:

Bulb / clove (as part-nature) (A067A)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

lycorine, galanthamine, lycorenine, pluviine, maritidine, galanthine, flexinine, cherylline, crinine and derivatives, chlidanthine, narwedine, ungeremine, haemanthidine, hippeastrine, haemanthamine etc.
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Isoquinoline alkaloids in bulbs