EFSA Compendium of Botanicals

Draft - work in progress

Lythrum hyssopifolia L. // Chabraea hyssopifolia (L.) Bubani

Family:: Lythraceae
Approval state:: Approved
Number of articles retrieved:: 2
Number of processed references:: 2

Compositions

Endpoint Studies

#1: Nephrotoxicity #2: Hepatotoxicity #3: Neurotoxicity #4: Nephrotoxicity #5: Clinical pathology and gross pathology changes; mortality

Genotoxicity

Endpoint study #1: Lancaster, M. J., Nimmo, J. S., Lenghaus, C., Gill, I. J., Crawford, R. D., Badman, R. T., Samuel, J. L., Werner, C. J., Button, C., Kvalheim, N. Lythrum hyssopifolia (lesser loosestrife) poisoning of sheep in Victoria. australian veterinary journal, 2009, vol. 87, no. 12, p. 476–479. DOI: 10.1111/j.1751-0813.2009.00512.x. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Sheep (as animal) (A057G)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

Nephrotoxicity (pale and/or swollen, with perirenal oedema in kidneys, tubular necrosis)
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Nephrotoxicity

Endpoint study #2: Lancaster, M. J., Nimmo, J. S., Lenghaus, C., Gill, I. J., Crawford, R. D., Badman, R. T., Samuel, J. L., Werner, C. J., Button, C., Kvalheim, N. Lythrum hyssopifolia (lesser loosestrife) poisoning of sheep in Victoria. australian veterinary journal, 2009, vol. 87, no. 12, p. 476–479. DOI: 10.1111/j.1751-0813.2009.00512.x. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Sheep (as animal) (A057G)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Hepatotoxicity (mottled or having an accentuated lobular pattern, necroses)
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Hepatotoxicity

Endpoint study #3: Lancaster, M. J., Nimmo, J. S., Lenghaus, C., Gill, I. J., Crawford, R. D., Badman, R. T., Samuel, J. L., Werner, C. J., Button, C., Kvalheim, N. Lythrum hyssopifolia (lesser loosestrife) poisoning of sheep in Victoria. australian veterinary journal, 2009, vol. 87, no. 12, p. 476–479. DOI: 10.1111/j.1751-0813.2009.00512.x. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Sheep (as animal) (A057G)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

Terminal depression, blindness, recumbency and mild convulsions or extensor; photosensitivity; disurea; 1-20% mortality
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Neurotoxicity

Endpoint study #4: Tran, J. N., Yang, P-J., Morton, A. G., Todd, A. A., Boulton, J. G., Philbey, A. W. Suspected Lythrum hyssopifolia (lesser loosestrife) poisoning of cattle. australian veterinary journal, 2013, vol. 91, no. 11, p. 474–476. DOI: 10.1111/avj.12114. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

108
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEPHROTOXICITY (TOX03A)
Target tissue:

urogenital: Kidneys (TT046A)
Effect description:

nephrotoxicity (kidney from the euthanased cow showed severe, acute, segmental degeneration and necrosis of epithelial cells lining proximal convoluted tubules in the renal cortex)
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Nephrotoxicity

Endpoint study #5: Tran, J. N., Yang, P-J., Morton, A. G., Todd, A. A., Boulton, J. G., Philbey, A. W. Suspected Lythrum hyssopifolia (lesser loosestrife) poisoning of cattle. australian veterinary journal, 2013, vol. 91, no. 11, p. 474–476. DOI: 10.1111/avj.12114. [DOI link]

Study relevance:

Animal (target species) health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Fresh (A166Y)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Cattle (as animal) (A057E)
Sex:

No data
Route of exposure:

ORAL: FEED (OECD2230PL)
Number of organisms dosed:

108
Control groups used:

no data
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

SYSTEMIC (TOX01A)
Effect description:

Clinical pathology changes; gross pathology changes (congestion of the lungs, omentum, abomasal mucosa, small intestine and caecum; pale brown kidneys; haemorrhages in the small intestine and caecum; 18.5% mortality of adult cows
Effect or parameter linked to the endpoint:

mortality (CHD010BE)
Internal remarks:

Clinical pathology and gross pathology changes; mortality