EFSA Compendium of Botanicals

Endpoint study #1: Yoshida, Kaori., Hishida, Atsuyuki., Iida, Osamu., Hosokawa, Keizo., Kawabata, Jun. Flavonol caffeoylglycosides as alpha-glucosidase inhibitors from Spiraea cantoniensis flower . journal of agricultural and food chemistry, 2008, vol. 56, no. 12, p. 4367–4371. DOI: 10.1021/jf8007579. [DOI link]

Study relevance:

Human health
Plant part:

Flower (as part-nature) (A067B)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water, ethyl acetate
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

50
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

in vitro inhibition of rat intestinal alpha-glucosidase ( 91% inhibition of maltase and sucrase)
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

Rat Intestinal alpha-glucosidase inhibition (in vitro)

Spiraea cantoniensis Lour.