EFSA Compendium of Botanicals

Draft - work in progress

Eriophyllum lanatum (Pursh) J.Forbes

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 4
Number of processed references:: 4

Compositions

#1: Erioflorin (sesquiterpene lactone) #2: Eriolanin (sesquiterpene lactones) #3: eriolangin (sesquiterpene lactone) #4: Thiophenes (E. lanatum)

Endpoint Studies

Genotoxicity

Composition #1: Blees, Johanna S., Bokesch, Heidi R., Rubsamen, Daniela., Schulz, Kathrin., Milke, Larissa., Bajer, Magdalena M., Gustafson, Kirk R., Henrich, Curtis J., McMahon, James B., Colburn, Nancy H., Schmid, Tobias., Brune, Bernhard. Erioflorin stabilizes the tumor suppressor Pdcd4 by inhibiting its interaction with the E3-ligase beta-TrCP1. . plos one, 2012, vol. 7, no. 10, p. e46567. DOI: 10.1371/journal.pone.0046567. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

Erioflorin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Erioflorin (sesquiterpene lactone)

Composition #2: Bohlmann, Ferdinand., Zdero, Christa., Jakupovic, Jasmin., Robinson, Harold., King, Robert M. Naturally occurring terpene derivatives. Part 350. Eriolanolides, eudesmanolides, and a rearranged sesquiterpene from Eriophyllum species. phytochemistry (elsevier), 1981, p. 2239–2244. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

Eriolanin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Eriolanin (sesquiterpene lactones)

Composition #3: Kupchan, S.M., Baxter, R.L., Chiang, C.-K., Gilmore, C.J., Bryan, R.F. Eriolangin and eriolanin, novel antileukaemic seco-eudesmanolides from Eriophyllum lanatum. journal of the chemical society, chemical communications, 1973, no. 21, p. 842–843. DOI: 10.1039/C39730000842. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Sesquiterpene lactones (RF-00004319-PAR)
Additional substance description:

Eriolangin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

eriolangin (sesquiterpene lactone)

Composition #4: Page, JE., Huffman, MA., Smith, V., Towers, GHN. Chemical basis for Aspilia leaf-swallowing by chimpanzees: A reanalysis. journal of chemical ecology, 1997, vol. 23, no. 9, p. 2211–2226. DOI: 10.1023/B:JOEC.0000006440.57230.a9. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol or ethanol
Substance:

furan derivatives (RF-00004396-PAR)
Additional substance description:

thiophenes
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Result unit:

Microgram/gram (G049A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

6.8
Internal remarks:

Thiophenes (E. lanatum)