EFSA
ecomole
vscht
  2. Reynoutria multiflora (Thunb.) Moldenke // Fallopia multiflora (Thunb.) Haraldson // Polygonum multiflorum Thunb.

Reynoutria multiflora (Thunb.) Moldenke // Fallopia multiflora (Thunb.) Haraldson // Polygonum multiflorum Thunb.

Family:
Polygonaceae
Approval state:
Approved
Number of articles retrieved:
4215
Number of processed references:
8
Compositions
#1: Cis-stilbene glucoside in roots #2: indole alkaloids in roots #3: physcion in roots #4: chrysophanol in roots #5: sennoside A in roots #6: sennoside B in roots #7: aloe-emodin in roots #8: chrysophanol in roots #9: rhein in roots #10: emodin in roots #11: physcion in roots #12: physcion in roots #13: anthraquinone (aloe-emodine, rheine, emodine, chrysophanol and physcione) in roots #14: emodine in roots
Endpoint Studies
#1: Hepatotoxicity in humans #2: alpha-glucosidase inhibition in humans Substance in the plant: emodin, physcion, aloeemodin, rhein, physcion-8-O-glucoside, 2,3,5, tetrahydroxystilbene-2-O-glucoside, torachryson-8-O-glucoside,catechin and resveratrol. #3: Hepatotoxicity in rats. The main constituents of PMR extract, include 2,3,5,40 -tetrahydroxystilbene-2-O-β-D-glucoside (TSG), emodin-8-O-β-D-glucoside and emodin
Genotoxicity
#1: P. multiflorum (3.9 g/kg and 11.7 g/kg) had harmful effects on peripheral lymphocyte DNA on the first, third and seventh day as demonstrated by changes in tail DNA, olive moment, tail length, and/or tail moment.
Composition #1: Meng, Ya-Kun., Li, Chun-Yu., Li, Rui-Yu., He, Lan-Zhi., Cui, He-Rong., Yin, Ping., Zhang, Cong-En., Li, Peng-Yan., Sang, Xiu-Xiu., Wang, Ya., Niu, Ming., Zhang, Ya-Ming., Guo, Yu-Ming., Sun, Rong., Wang, Jia-Bo., Bai, Zhao-Fang., Xiao, Xiao-He. Cis-stilbene glucoside in Polygonum multiflorum induces immunological idiosyncratic hepatotoxicity in LPS-treated rats by suppressing PPAR-gamma. . acta pharmacologica sinica, 2017 . DOI: 10.1038/aps.2017.32. [DOI link]
Composition #2: Yang, Xiuwei., Gu, Zheming., Ma, Chaomei., Hattori, Masao., Namba, Tsuneo. A new indole derivative isolated from the root of tuber fleece-flower.. zhongcaoyao, 1998, vol. 29, no. 1, p. 5–11. .
Composition #3: Yang, Xiuwei., Gu, Zheming., Ma, Chaomei., Hattori, Masao., Namba, Tsuneo. A new indole derivative isolated from the root of tuber fleece-flower.. zhongcaoyao, 1998, vol. 29, no. 1, p. 5–11. .
Composition #4: Yang, Xiuwei., Gu, Zheming., Ma, Chaomei., Hattori, Masao., Namba, Tsuneo. A new indole derivative isolated from the root of tuber fleece-flower.. zhongcaoyao, 1998, vol. 29, no. 1, p. 5–11. .
Composition #5: Yang, Xiuwei., Gu, Zheming., Ma, Chaomei., Hattori, Masao., Namba, Tsuneo. A new indole derivative isolated from the root of tuber fleece-flower.. zhongcaoyao, 1998, vol. 29, no. 1, p. 5–11. .
Composition #6: Yang, Xiuwei., Gu, Zheming., Ma, Chaomei., Hattori, Masao., Namba, Tsuneo. A new indole derivative isolated from the root of tuber fleece-flower.. zhongcaoyao, 1998, vol. 29, no. 1, p. 5–11. .
Composition #7: Zuo, Yuegang., Wang, Chengjun., Lin, Yuejuan., Guo, Jinwen., Deng, Yiwei. Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection . journal of chromatography a, 2008, vol. 1200, no. 1, p. 43–48. DOI: 10.1016/j.chroma.2008.01.058. [DOI link]
Composition #8: Zuo, Yuegang., Wang, Chengjun., Lin, Yuejuan., Guo, Jinwen., Deng, Yiwei. Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection . journal of chromatography a, 2008, vol. 1200, no. 1, p. 43–48. DOI: 10.1016/j.chroma.2008.01.058. [DOI link]
Composition #9: Zuo, Yuegang., Wang, Chengjun., Lin, Yuejuan., Guo, Jinwen., Deng, Yiwei. Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection . journal of chromatography a, 2008, vol. 1200, no. 1, p. 43–48. DOI: 10.1016/j.chroma.2008.01.058. [DOI link]
Composition #10: Zuo, Yuegang., Wang, Chengjun., Lin, Yuejuan., Guo, Jinwen., Deng, Yiwei. Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection . journal of chromatography a, 2008, vol. 1200, no. 1, p. 43–48. DOI: 10.1016/j.chroma.2008.01.058. [DOI link]
Composition #11: Zuo, Yuegang., Wang, Chengjun., Lin, Yuejuan., Guo, Jinwen., Deng, Yiwei. Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection . journal of chromatography a, 2008, vol. 1200, no. 1, p. 43–48. DOI: 10.1016/j.chroma.2008.01.058. [DOI link]
Composition #12: Jiao, Yue., Zuo, Yuegang. Ultrasonic Extraction and HPLC Determination of Anthraquinones, Aloe-emodine, Emodine, Rheine, Chrysophanol and Physcione, in Roots of Polygoni multiflori . phytochemical analysis, 2009, vol. 20, no. 4, p. 272–278. DOI: 10.1002/pca.1124. [DOI link]
Composition #13: Jiao, Yue., Zuo, Yuegang. Ultrasonic Extraction and HPLC Determination of Anthraquinones, Aloe-emodine, Emodine, Rheine, Chrysophanol and Physcione, in Roots of Polygoni multiflori . phytochemical analysis, 2009, vol. 20, no. 4, p. 272–278. DOI: 10.1002/pca.1124. [DOI link]
Composition #14: Jiao, Yue., Zuo, Yuegang. Ultrasonic Extraction and HPLC Determination of Anthraquinones, Aloe-emodine, Emodine, Rheine, Chrysophanol and Physcione, in Roots of Polygoni multiflori . phytochemical analysis, 2009, vol. 20, no. 4, p. 272–278. DOI: 10.1002/pca.1124. [DOI link]
Endpoint study #1: Calitz, C., Du Plessis, L., Gouws, C., Steyn, D., Steenekamp, J., Muller, C., Hamman, S. Herbal hepatotoxicity: Current status, examples, and challenges. expert opinion on drug metabolism and toxicology, 2015, vol. 11, no. 10, p. 1551–1565. DOI: 10.1517/17425255.2015.1064110. [DOI link]
Endpoint study #2: Yang, Dong., Zhao, Jiadi., Liu, Shu., Song, Fengrui., Liu, Zhiqiang. The screening of potential alpha-glucosidase inhibitors from the Polygonum multiflorum extract using ultrafiltration combined with liquid chromatography-tandem mass spectrometry . analytical methods, 2014, vol. 6, no. 10, p. 3353–3359. DOI: 10.1039/c4ay00064a. [DOI link]
Endpoint study #3: Ma, Jiang., Zheng, Li., He, Yi-Sheng., Li, Hui-Jun. Hepatotoxic assessment of Polygoni Multiflori Radix extract and toxicokinetic study of stilbene glucoside and anthraquinones in rats . journal of ethnopharmacology, 2015, vol. 162, p. 61–68. DOI: 10.1016/j.jep.2014.12.045. [DOI link]
Genotox #1: Zhang, Qiuhua., Wu, Chunfu., Duan, Lian., Yang, Jingyu. Genotoxic studies on Panax ginseng and Polygonum multiflorum and their combination in mouse peripheral lymphocyte cells.. asian journal of traditional medicines, 2007, vol. 2, no. 4, p. 127–134. .