EFSA Compendium of Botanicals

Draft - work in progress

Wisteria sinensis (Sims) Sweet

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 188
Number of processed references:: 5

Compositions

#1: lectins in seeds #2: Medicarpin #3: syringaresinol #4: isoduartin #5: p-hydroxy-benzaldehyde #6: formononetin #7: 6-Methoxy-4H-1-benzopyran-7-ol in flowers #8: Scopoletine in flowers #9: Methyl isoeugenol in flowers #10: Indole in flowers #11: eugenol in flowers #12: isoeugenol in flowers #13: Methyl salicylate in flowers #14: 1,8-Cineole in flowers

Endpoint Studies

#1: gastrointestinal disturbances

Genotoxicity

Composition #1: Freier, Thomas., Fleischmann, Guenter., Ruediger, Harold. Affinity chromatography on immobilized hog gastric mucin and ovomucoid. A general method for isolation of lectins. biological chemistry hoppe-seyler, 1985, vol. 366, no. 11, p. 1023–8. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water + methanol and dichloromethane
Substance:

Lectins (RF-00000439-ORG)
Analytical method code:

Capillary (Zone) Electrophoresis (CE or CZE) (F071A)
Result unit:

Milligram/100 gram (G057A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

160
Internal remarks:

lectins in seeds

Composition #2: Liu, Jin-Song., Chen, Ai-Min., Xu, Ying-Sheng., Wang, Gang., Wang, Guo-Kai. Phenolic derivatives from Wisteria sinensis sweet caulis .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 9, p. 1437–40. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% alcohol permeating extraction,
Substance:

Medicarpin (RF-00011248-PAR)
Additional substance description:

medicarpin, 1-dihydromedicarpin (8), 3-hydroxy-medicarpin (9)
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Medicarpin

Composition #3: Liu, Jin-Song., Chen, Ai-Min., Xu, Ying-Sheng., Wang, Gang., Wang, Guo-Kai. Phenolic derivatives from Wisteria sinensis sweet caulis .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 9, p. 1437–40. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% alcohol permeating extraction,
Substance:

syringaresinol (RF-00011386-PAR)
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

syringaresinol

Composition #4: Liu, Jin-Song., Chen, Ai-Min., Xu, Ying-Sheng., Wang, Gang., Wang, Guo-Kai. Phenolic derivatives from Wisteria sinensis sweet caulis .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 9, p. 1437–40. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% alcohol permeating extraction,
Substance:

duartin (RF-00003786-PAR)
Additional substance description:

isoduartin
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

isoduartin

Composition #5: Liu, Jin-Song., Chen, Ai-Min., Xu, Ying-Sheng., Wang, Gang., Wang, Guo-Kai. Phenolic derivatives from Wisteria sinensis sweet caulis .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 9, p. 1437–40. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% alcohol permeating extraction,
Substance:

4-Hydroxybenzaldehyde (RF-00001976-PAR)
Additional substance description:

p-hydroxy-benzaldehyde
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

p-hydroxy-benzaldehyde

Composition #6: Liu, Jin-Song., Chen, Ai-Min., Xu, Ying-Sheng., Wang, Gang., Wang, Guo-Kai. Phenolic derivatives from Wisteria sinensis sweet caulis .. zhong yao cai = zhongyaocai = journal of chinese medicinal materials, 2013, vol. 36, no. 9, p. 1437–40. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% alcohol permeating extraction,
Substance:

formononetin (RF-00000291-NTR)
Analytical method code:

Gaschromatography (GC) (F037A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

formononetin

Composition #7: Demyttenaere, J., Van Syngel, K., Markusse, AP., Vervisch, S., Debenedetti, S., De Kimpe, N. Synthesis of 6-methoxy-4H-1-benzopyran-7-ol, a character donating component of the fragrance of Wisteria sinensis . tetrahedron, 2002, vol. 58, no. 11, p. 2163–2166. DOI: 10.1016/S0040-4020(02)00081-9. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

Coumarin (RF-00000370-TOX)
Additional substance description:

6-Methoxy-4H-1-benzopyran-7-ol
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.6
Internal remarks:

6-Methoxy-4H-1-benzopyran-7-ol in flowers

Composition #8: Demyttenaere, J., Van Syngel, K., Markusse, AP., Vervisch, S., Debenedetti, S., De Kimpe, N. Synthesis of 6-methoxy-4H-1-benzopyran-7-ol, a character donating component of the fragrance of Wisteria sinensis . tetrahedron, 2002, vol. 58, no. 11, p. 2163–2166. DOI: 10.1016/S0040-4020(02)00081-9. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

scopoletin (RF-00004048-PAR)
Analytical method code:

GC-MS (F046A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Scopoletine in flowers

Composition #9: Jiang, Yifan., Chen, Xinlu., Lin, Hong., Wang, Fei., Chen, Feng. Floral Scent in Wisteria: Chemical Composition, Emission Pattern, and Regulation . journal of the american society for horticultural science, 2011, vol. 136, no. 5, p. 307–314. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

water
Substance:

Eugenol (RF-00003807-PAR)
Additional substance description:

Methyl isoeugenol
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

VOLATILE COLLECTION - open headspace sampling system
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

39.9
Internal remarks:

Methyl isoeugenol in flowers

Composition #10: Jiang, Yifan., Chen, Xinlu., Lin, Hong., Wang, Fei., Chen, Feng. Floral Scent in Wisteria: Chemical Composition, Emission Pattern, and Regulation . journal of the american society for horticultural science, 2011, vol. 136, no. 5, p. 307–314. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

water
Substance:

Indole (RF-00008427-PAR)
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

VOLATILE COLLECTION - open headspace sampling system
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

207
Internal remarks:

Indole in flowers

Composition #11: Jiang, Yifan., Chen, Xinlu., Lin, Hong., Wang, Fei., Chen, Feng. Floral Scent in Wisteria: Chemical Composition, Emission Pattern, and Regulation . journal of the american society for horticultural science, 2011, vol. 136, no. 5, p. 307–314. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

water
Substance:

Eugenol (RF-00003807-PAR)
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

VOLATILE COLLECTION - open headspace sampling system
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

15.4
Internal remarks:

eugenol in flowers

Composition #12: Jiang, Yifan., Chen, Xinlu., Lin, Hong., Wang, Fei., Chen, Feng. Floral Scent in Wisteria: Chemical Composition, Emission Pattern, and Regulation . journal of the american society for horticultural science, 2011, vol. 136, no. 5, p. 307–314. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

water
Substance:

Eugenol (RF-00003807-PAR)
Additional substance description:

isoeugenol
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

VOLATILE COLLECTION - open headspace sampling system
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

61.1
Internal remarks:

isoeugenol in flowers

Composition #13: Jiang, Yifan., Chen, Xinlu., Lin, Hong., Wang, Fei., Chen, Feng. Floral Scent in Wisteria: Chemical Composition, Emission Pattern, and Regulation . journal of the american society for horticultural science, 2011, vol. 136, no. 5, p. 307–314. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

water
Substance:

methyl salicylate (RF-00003930-PAR)
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

VOLATILE COLLECTION - open headspace sampling system
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

356.0
Internal remarks:

Methyl salicylate in flowers

Composition #14: Jiang, Yifan., Chen, Xinlu., Lin, Hong., Wang, Fei., Chen, Feng. Floral Scent in Wisteria: Chemical Composition, Emission Pattern, and Regulation . journal of the american society for horticultural science, 2011, vol. 136, no. 5, p. 307–314. .

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Super-critical gas extraction (A0BZQ)
Additional extraction description:

water
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

VOLATILE COLLECTION - open headspace sampling system
Result unit:

Nanogram/gram (G076A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

128.2
Internal remarks:

1,8-Cineole in flowers

Endpoint study #1: Tubaro, P. G., Sacco, G., Sosa, S., Tubaro, A. Toxicity of Wisteria sinensis (Sims) Sweet seeds. pharmaceutical and pharmacological letters, 2001, vol. 11, no. 2, p. 58–60. .

Study relevance:

Human health
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male/Female
Exposure duration:

15.0
Unit of exposure duration:

Minute (G074A)
Number of organisms dosed:

5
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Target tissue:

digestive: Stomach (TT027A)
Effect description:

gastrointestinal disturbances(vomiting and strong stomach and abdominal pain). Also hyperventilation, dyspnea, psychomotor agitation, paleness, and algid sweat. Three of them were hospitalised. anxia, confusion, mydriatic, but reacted normally to light.
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

gastrointestinal disturbances