Composition #1: Champy, Anne-Sophie., Mitaine-Offer, Anne-Claire., Paululat, Thomas., Papini, Anna-Maria., Lacaille-Dubois, Marie-Aleth. Triterpene Saponins from Wisteria floribunda "macrobotrys" and "rosea". natural product communications, 2017, vol. 12, no. 10, p. 1573–1576. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
Ethanol, water (75/35)
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Substance:
Triterpene saponins Triterpene saponins (RF-00004338-PAR)
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Additional substance description:
3-O--D-xylopyranosyl-(12)--D-glucuronopyranosyl-22-Oacetyl-3,22,24-trihydroxyolean-12-en-30-oic acid
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
TLC, GC, HMDS-TMCS
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
triterpene saponins in roots
Endpoint study
#1: Kim, Dongwan., Park, Jihyoung., Kim, Yun Mi., Tchah, Hann. Acute intoxication due to Wisteria floribunda seed in seven young children . pediatrics international, 2017, vol. 59, no. 5, p. 600–603. DOI: 10.1111/ped.13218.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Ripe / mature (A07XL)
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Type of toxicological test:
case report (CHD060TT)
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Limit test:
Not applicable
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Tested organism:
Human (as organism) (A056J)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
single (food/feed) (G203A)
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Number of organisms dosed:
7
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
digestive: Stomach (TT027A)
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Effect description:
vomiting, abdominal pain, leukocytosis
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
gastrointestinal symptoms
Endpoint study
#2: Kim, Dongwan., Park, Jihyoung., Kim, Yun Mi., Tchah, Hann. Acute intoxication due to Wisteria floribunda seed in seven young children . pediatrics international, 2017, vol. 59, no. 5, p. 600–603. DOI: 10.1111/ped.13218.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Preparation/Extraction method:
Ripe / mature (A07XL)
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Type of toxicological test:
case report (CHD060TT)
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Limit test:
Not applicable
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Tested organism:
Human (as organism) (A056J)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
single (food/feed) (G203A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Neurologic (TT004A)
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Effect description:
vomiting, abdominal pain, lethargic, leukocytosis
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
neurologic symptoms
Endpoint study
#3: RONDEAU, ES. WISTERIA TOXICITY. journal of toxicology-clinical toxicology, 1993, vol. 31, no. 1, p. 107–112. .
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Study relevance:
Human health
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Plant part:
Seed (as part-nature) (A066P)
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Type of toxicological test:
case report (CHD060TT)
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Tested organism:
Human (as organism) (A056J)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Unit of exposure duration:
single (food/feed) (G203A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose level (CHD014EP)
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Concentration unit:
Piece (G133A)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Digestive (TT002A)
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Effect description:
headache, gastroenteritis, hematemesis, dizziness, confusion, diaphoresis, syncopal episode, fatigue, dizziness
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
neurologic symptoms
