EFSA Compendium of Botanicals

Draft - work in progress

Vinca major L.

Family:: Apocynaceae
Approval state:: Approved
Number of articles retrieved:: 266
Number of processed references:: 9

Compositions

#1: indole alkaloids (10-methoxyperakine, vincawajine, 10-methoxyvinorine) in aerial part #2: akuammicine in aerial part #3: 11-hydroxypolyneuridine in aerial part #4: syringaresinol in leaves #5: vinmajine A-I #6: Indole alkaloids (other half of derivatives listed) in whole plant #7: Indole alkaloids (half of derivatives listed) in whole plant #8: indole alkaloids in whole plant #9: vinmajpyridine A-C in aerial parts #10: 10-methoxytetrahydroalstonine in whole plant

Endpoint Studies

Genotoxicity

Composition #1: Atta-Ur-Rahman, Abida Sultana., Nighat, Farzana., Bhatti, M. Khalid., Kurucu, Semra., Kartal, Murat. Alkaloids from Vinca major. phytochemistry (oxford), 1995, vol. 38, no. 4, p. 1057–1061. DOI: 10.1016/0031-9422(94)00638-A. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

10-methoxyperakine, vincawajine, 10-methoxyvinorine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

TLC, UV, IR, NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

indole alkaloids (10-methoxyperakine, vincawajine, 10-methoxyvinorine) in aerial part

Composition #2: Il'yashenko, L.I., Malikov, V.M., Yagudaev, M.R., Yunusov, S.Yu. Alkaloids of Vinca major. chemistry of natural compounds, 1977, vol. 13, no. 3, p. 324–327. DOI: 10.1007/BF00573553. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

akuammicine
Analytical method code:

IR and Raman Spectroscopy (F010A)
Analytical method - additional description:

IR, MS, UV, PMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

akuammicine in aerial part

Composition #3: Bahadori, Fatemeh., Topcu, Gulacti., Boga, Mehmet., Turkekul, Ayla., Kolak, Ufuk., Kartal, Murat. Indole Alkaloids from Vinca major and V. minor Growing in Turkey. natural product communications, 2012, vol. 7, no. 6, p. 731–734. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

11-hydroxypolyneuridine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

TLC, APCI-HRMS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

11-hydroxypolyneuridine in aerial part

Composition #4: Sohretoglu, Didem., Masullo, Milena., Piacente, Sonia., Kirmizibekmez, Hasan. Iridoids, monoterpenoid glucoindole alkaloids and flavonoids from Vinca major . biochemical systematics and ecology, 2013, vol. 49, p. 69–72. DOI: 10.1016/j.bse.2013.03.028. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

syringaresinol (RF-00011386-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

NMR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

syringaresinol in leaves

Composition #5: Cheng, Gui-Guang., Zhao, Yun-Li., Zhang, Yu., Lunga, Paul-Keilah., Hu, Dong-Bao., Li, Yan., Gu, Ji., Song, Chang-Wei., Sun, Wei-Bang., Liu, Ya-Ping., Luo, Xiao-Dong. Indole alkaloids from cultivated Vinca major. tetrahedron, 2014, vol. 70, no. 45, p. 8723–8729. DOI: 10.1016/j.tet.2014.09.026. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

vinmajine A-I
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, IR, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

vinmajine A-I

Composition #6: Zhang, Zhi-Jun., Du, Ru-Nan., He, Juan., Wu, Xing-De., Li, Yan., Li, Rong-Tao., Zhao, Qin-Shi. Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major. helvetica chimica acta, 2016, vol. 99, no. 2, p. 157–160. DOI: 10.1002/hlca.201500211. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

90% Ethanol
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

pseudoakuammigine, akuammine, 10- hydroxy desacetyl-akuammiline, sitsirikine, isositsirikine, dihydrositsirikine, rhazimine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ms, uv, ir
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Indole alkaloids (other half of derivatives listed) in whole plant

Composition #7: Zhang, Zhi-Jun., Du, Ru-Nan., He, Juan., Wu, Xing-De., Li, Yan., Li, Rong-Tao., Zhao, Qin-Shi. Vinmajorines C-E, Monoterpenoid Indole Alkaloids from Vinca major. helvetica chimica acta, 2016, vol. 99, no. 2, p. 157–160. DOI: 10.1002/hlca.201500211. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

90% Ethanol
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

vinmajorines C – E, reserpinine, ajmalicine, 11-hydroxyajmalicine, vallesiachotamine, strictosamide, majdine, (+)-vincadifformine , (-)-quebrachamine, rhazinilam, tetrahydromeloscine,
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ms, uv, ir
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Indole alkaloids (half of derivatives listed) in whole plant

Composition #8: Zhang, Zhi-Jun., Du, Ru-Nan., He, Juan., Wu, Xing-De., Li, Yan., Li, Rong-Tao., Zhao, Qin-Shi. Three new monoterpenoid indole alkaloids from Vinca major. journal of asian natural products research, 2016, vol. 18, no. 4, p. 328–333. DOI: 10.1080/10286020.2015.1094463. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 90%
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

19-hydroxyl-10-methoxy-19, 20-dihydrovinorine, 19-O-acetyl-10-methoxy-19, 20-dihydrovinorine, 19, 21α-dihydroxyl-10-methoxy-19, 20-dihydrovinorine, 10-methoxyvinorine, majoridine, vincamajoridine, vincamedine, vinorine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, IR, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

indole alkaloids in whole plant

Composition #9: Wei, Xin., Khan, Afsar., Song, Da., Dai, Zhi., Liu, Ya-Ping., Yu, Hao-Fei., Wang, Bei., Zhu, Pei-Feng., Ding, Cai-Feng., Zhao, Xu-Dong., Wang, Yi-Fen., Luo, Xiao-Dong. Three New Pyridine Alkaloids from Vinca major Cultivated in Pakistan. natural products and bioprospecting, 2017, vol. 7, no. 4, p. 323–327. DOI: 10.1007/s13659-017-0137-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

pyridine alkaloids (RF-00010801-PAR)
Additional substance description:

vinmajpyridine A-C
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR,HRESIMS, IR, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

vinmajpyridine A-C in aerial parts

Composition #10: MUKHOPADHYAY, G., MUKHERJEE, B., PATRA, A., CHATTERJEE, A., GHOSH, R., ROYCHOWDHURY, P., KAWAZURA, H. 11-METHOXYTETRAHYDROALSTONINE, A HETEROYOHIMBINOID ALKALOID FROM VINCA-MAJOR . phytochemistry, 1991, vol. 30, no. 7, p. 2447–2449. DOI: 10.1016/0031-9422(91)83682-B. [DOI link]

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH-HOAc (95:6)
Substance:

10-methoxytetrahydroalstonine (RF-00003660-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR, IR, UV
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

10-methoxytetrahydroalstonine in whole plant