EFSA Compendium of Botanicals

Draft - work in progress

Vinca erecta Regel & Schmalh.

Family:: Apocynaceae
Approval state:: Approved
Number of articles retrieved:: 150
Number of processed references:: 11

Compositions

#1: hydroxyindole alkaloids (majdinine, 8-oxo-6,7-dehydrokopsinine N-oxide) in unspecified part #2: vincanine, vincanidine, vinervine, akuammine, kopsinine, pseudokopsinine, vinerine and vineridine in aerial parts #3: vincanine in roots #4: Indole alkaloids in aerial parts #5: vincamine in aerial parts #6: indole alkaloids in roots #7: kopsanone, Kopsinilam, 5,22-dioxokopsane in unspecified part #8: ercinamine and ercinaminine in unspecified part #9: alkaloids (vincamine, vincanlne, vinervinine, ervamine, akuammicine, vincanidine, akuammine, ll-hydroxypleiocarpamine) in aerial parts #10: Indole alkaloids in aerial parts #11: indole alkaloids in aerial parts

Endpoint Studies

Genotoxicity

Composition #1: Kuchenkova, M.A., Yuldashev, P. Kh., Yunusov, S. Yu. Alkaloids of Vinca erecta. doklady akademii nauk uzssr, 1964, vol. 21, no. 11, p. 42–5. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

majdinine, 8-oxo-6,7-dehydrokopsinine N-oxide
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ms, uv, ir
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

hydroxyindole alkaloids (majdinine, 8-oxo-6,7-dehydrokopsinine N-oxide) in unspecified part

Composition #2: Kasymov, Sh. Z., Yuldashev, P. Kh., Yunusov, S. Yu. Structure of vinerine and vineridine. khimiya prirodnykh soedinenii, 1966, vol. 2, no. 4, p. 260–5. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ether
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

vincanine, vincanidine, vinervine, akuammine, kopsinine, pseudokopsinine, vinerine and vineridine
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

IR, UV, specific rotation, paper chromatography, elemental analysis
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.7
Internal remarks:

vincanine, vincanidine, vinervine, akuammine, kopsinine, pseudokopsinine, vinerine and vineridine in aerial parts

Composition #3: Mirkina, R. A., Arinov, Kh. N., Shakirov, T. T., Malikov, V. M. Control of the production of vincanine hydrochloride. khimiko-farmatsevticheskii zhurnal, 1967, vol. 1, no. 5, p. 55–7. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

5% ammonia solution and chloroform extraction
Substance:

vincanine (RF-00003518-PAR)
Analytical method code:

Colorimetry, Spectroscopy (Spectrometry) and Photometry (F008A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.20 - 0.78
Internal remarks:

vincanine in roots

Composition #4: Abdurakhimova, N., Yuldashev, P. Kh., Yunusov, S. Yu. Constitution of majdine, pseudokopsinine and vinervinine. khimiya prirodnykh soedinenii, 1967, vol. 3, no. 5, p. 310–15. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

kopsinine nitrate, vincanidine, vinervine, ervidinine, vincanine, vincarine, akuammidine, tombosine, reserpinine, ervine
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Indole alkaloids in aerial parts

Composition #5: Karabaev, Sh. Sh., Aripov, Kh. N., Shakirov, T. T. Isolation of vincamine. khimiya prirodnykh soedinenii, 1969, vol. 5, no. 3, p. 196. .

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ammonia + 85% ethanol
Substance:

vincamine (RF-00003625-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.03-0.035
Internal remarks:

vincamine in aerial parts

Composition #6: Sharipov, M., Malikov, V. M., Yunusov, S. Yu. Isolation of 6,7-dehydro-8-oxokopsinine, vincanine N-oxide and venalstonine from Vinca erecta. khimiya prirodnykh soedinenii, 1974, vol. 10, no. 2, p. 263–4. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chlorofom + methanol
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

6,7- dehydro- 8-oxokopsintne, vincanine-N-oxide, and venalstonine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ms, uv, ir
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

indole alkaloids in roots

Composition #7: Yagudaev, M.R. The NMR investigation of alkaloids. VII.13C NMR spectra and structure of "kopsanone" and kopsinilam. chemistry of natural compounds, 1984, vol. 20, no. 3, p. 320–322. DOI: 10.1007/BF00575758. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

kopsanone, Kopsinilam, 5,22-dioxokopsane
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

NMR and mass spectra
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

kopsanone, Kopsinilam, 5,22-dioxokopsane in unspecified part

Composition #8: Yagudaev, M.R., Khalmirzaev, M.M., Yunusov, S.Yu. NMR study of alkaloids. V.13C NMR spectra and reconsideration of the structures of 11- and 10-hydroxypleiocarpamines and the structures of new alkaloids from Vinca erecta. chemistry of natural compounds, 1983, vol. 19, no. 4, p. 454–458. DOI: 10.1007/BF00575706. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Methanol
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

ercinamine and ercinaminine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ms, uv, ir
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

ercinamine and ercinaminine in unspecified part

Composition #9: Il'yasova, Kh.T., Malikov, V.M., Yunusov, S.Yu. 11-Hydroxypleiocarpamine — A new alkaloid from Vinca erecta. chemistry of natural compounds, 1970, vol. 6, no. 6, p. 728–729. DOI: 10.1007/BF00565344. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

vincamine, vincanlne, vinervinine, ervamine, akuammicine, vincanidine, akuammine, ll-hydroxypleiocarpamine
Analytical method code:

Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) spectroscopy (F060A)
Analytical method - additional description:

MS and NMR
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.53
Internal remarks:

alkaloids (vincamine, vincanlne, vinervinine, ervamine, akuammicine, vincanidine, akuammine, ll-hydroxypleiocarpamine) in aerial parts

Composition #10: Rakhimov, D.A., Sharipov, M.R., Aripov, Kh.N., Malikov, V.M., Shakirov, T.T., Yunusov, S.Yu. The polybuffer separation of the alkaloids of Vinca erecta. chemistry of natural compounds, 1970, vol. 6, no. 6, p. 724–727. DOI: 10.1007/BF00565343. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

ervincidine, apovincamine, (+)-quebrachamine, dl-eburnamine, (-)-1,2-dehydroaspidospermidine, and kopsanone
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

ms, uv, ir
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Indole alkaloids in aerial parts

Composition #11: Adizov, Sh. M., Tashkhodzhaev, B., Bruskov, V. P., Talipov, S. A., Yuldashev, P. Kh., Malikov, V. M. On Nitrogen Coordination in Vincadifformine-Type Alkaloids. chemistry of natural compounds, 2017, vol. 53, no. 3, p. 512–516. DOI: 10.1007/s10600-017-2034-z. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ester
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

(–)-vincadifformine methyliodide and 5-oxo derivatives of (–)-vincadifformine ervinidinine and ervincinine
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

X-ray crystal structure analyses (XSAs)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

indole alkaloids in aerial parts