EFSA Compendium of Botanicals

Draft - work in progress

Valerian for root (as plant) // Valeriana officinalis L.

Family:: Caprifoliaceae
Approval state:: Approved
Number of articles retrieved:: 1623
Number of processed references:: 3

Compositions

#1: baldrinal and homobaldrinal in plant #2: alkaloids in plant

Endpoint Studies

Genotoxicity

#1: DNA damage following exposure with dichloromethane extracts

Composition #1: 이상협., 박현정. Studies on the Components of Valerian and Isovaleramide. yakhak hoeji, 2010, vol. 54, no. 1, p. 1–7. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

baldrinal (RF-00004171-PAR)
Additional substance description:

baldrinal and homobaldrinal
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

baldrinal and homobaldrinal in plant

Composition #2: Patocka, Jiri., Jaki, Jiri. Biomedically relevant chemical constituents of Valeriana officinalis. journal of applied biomedicine, 2010, vol. 8, no. 1, p. 11–18. DOI: 10.2478/v10136-009-0002-z. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

unspecified
Substance:

Alkaloids (RF-00004360-PAR)
Additional substance description:

actinidine, chatinine, valerianine, valerine, alpha-methyl pyrryl ketone and naphthyridin methyl ketone
Analytical method code:

Unspecified (F598A)
Analytical method - additional description:

from review paper
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids in plant

Genotox #1: Wang, HL., Zhang, DF., Luo, ZF., Lou, Y., Li, QR., Wang, YZ. In vitro study on the genotoxicity of dichloromethane extracts of valerian (DEV) in human endothelial ECV304 cells and the effect of vitamins E and C in attenuating the DEV-induced DNA damages . toxicology and applied pharmacology, 2003, vol. 188, no. 1, p. 36–41. DOI: 10.1016/S0041-008X(03)00017-6. [DOI link]

Study category:

Genotoxicity
Type of toxicological test:

single cell gel/comet assay in mammalian cells for detection of DNA damage (CHD040TT)
Method type:

in vitro
Tested organism:

Human (as organism) (A056J)
Exogenous metabolic activation applied:

not applicable
Control groups used:

yes, concurrent vehicle
Endpoint measured:

DNA damage and/or repair
Is genotoxic:

Positive
Remarks on genotox study:

a moderate degree of DNA damage was observed in the cells treated with 40 or 60 ug/mL of dichloromethane extracts of valerian in endothelial human cells
Internal remarks:

DNA damage following exposure with dichloromethane extracts
Internal ID:

WOS:000181999200005