EFSA Compendium of Botanicals

Draft - work in progress

Vaccaria hispanica (Mill.) Rauschert // Saponaria vaccaria L. // Vaccaria pyramidata Medik. // Vaccaria segetalis (Neck.) Garcke ex Asch.

Family:: Caryophyllaceae
Approval state:: Approved
Number of articles retrieved:: 499
Number of processed references:: 1

Compositions

Endpoint Studies

#1: diantheramide in vitro a-glucosidase inhibitory activity #2: segelin in vitro a-glucosidase inhibitory activity

Genotoxicity

Endpoint study #1: Zheng, Meng-Fei., Ren, Hui., Luo, Ying., Dong, Li-Mei., Wang, Ling-Qiong., Zhou, Zhong-Yu., Tan, Jian-Wen. A new diantheramide and a new cyclic peptide from the seeds of Vaccaria hispanica . phytochemistry letters, 2015, vol. 11, p. 240–244. DOI: 10.1016/j.phytol.2015.01.007. [DOI link]

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

A new diantheramide, cyclic peptide, 4,40 -dihydroxy-20 -methoxydianthramide, isolated from seeds of Vaccaria hispanica with 95% EtOH
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

0.080
Critical effect:

Other toxicities (TOX19A)
Effect description:

in vitro a-glucosidase inhibitory activity with IC50 values of 0.080 +/- 0.002 mM
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

diantheramide in vitro a-glucosidase inhibitory activity

Endpoint study #2: Zheng, Meng-Fei., Ren, Hui., Luo, Ying., Dong, Li-Mei., Wang, Ling-Qiong., Zhou, Zhong-Yu., Tan, Jian-Wen. A new diantheramide and a new cyclic peptide from the seeds of Vaccaria hispanica . phytochemistry letters, 2015, vol. 11, p. 240–244. DOI: 10.1016/j.phytol.2015.01.007. [DOI link]

Study relevance:

Human health
Plant part:

Seed (as part-nature) (A066P)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

new cyclic peptide, named segelin isolated from seeds of Vaccaria hispanica with 95% EtOH
Type of toxicological test:

in vitro (CHD061TT)
Endpoint measured:

Half maximal inhibitory concentration (CHD021EP)
Concentration unit:

Millimole (G115A)
Effect concentration:

0.28
Critical effect:

Other toxicities (TOX19A)
Effect description:

in vitro a-glucosidase inhibitory activity with IC50 values of 0.28 +/- 0.002 mM
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

segelin in vitro a-glucosidase inhibitory activity