EFSA
ecomole
vscht
  2. Tussilago farfara L.

Tussilago farfara L.

Family:
Asteraceae
Approval state:
Approved
Number of articles retrieved:
1255
Number of processed references:
7
Compositions
#1: Senecionine in flowers and in rhizomes #2: Senkirkine in flowers and in leaves #3: Senkirkine in flowers and in rhizomes #4: Senecionine in flowers #5: Senkirkine in flowers #6: Senecionine N-Oxide in flowers #7: Pyrrolizidine alkaloids (Senkirkine + Senecionine) in leaves #8: Senecionine in leaves #9: Senkirkine in leaves #10: Pyrrolizidine alkaloids (Senkirkine, senecionine, integerrimine and seneciphylline) in leaves #11: Senkirkine in dried flowers #12: Tussilagine and Isotussilagine in dried flowers
Endpoint Studies
#1: decrease in weight gain, increased levels of liver enzymes in serum of mouse injuries in liver tissue of mice #2: Alpha-glucosidase inhibition: maltase / sucrase
Genotoxicity
Composition #1: Mroczek, Tomasz., Glowniak, Kazimierz., Wlaszczyk, Anna. Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. journal of chromatography a, 2002, vol. 949(1-2), p. 249–262. .
Composition #2: Mroczek, Tomasz., Glowniak, Kazimierz., Wlaszczyk, Anna. Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. journal of chromatography a, 2002, vol. 949(1-2), p. 249–262. .
Composition #3: Mroczek, Tomasz., Glowniak, Kazimierz., Wlaszczyk, Anna. Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography. journal of chromatography a, 2002, vol. 949(1-2), p. 249–262. .
Composition #4: Avula, B., Sagi, S., Wang, Y.-H., Zweigenbaum, J., Wang, M., Khan, I.A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. food chemistry, 2015, vol. 178, p. 136–148. DOI: 10.1016/j.foodchem.2015.01.053. [DOI link]
Composition #5: Avula, B., Sagi, S., Wang, Y.-H., Zweigenbaum, J., Wang, M., Khan, I.A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. food chemistry, 2015, vol. 178, p. 136–148. DOI: 10.1016/j.foodchem.2015.01.053. [DOI link]
Composition #6: Avula, B., Sagi, S., Wang, Y.-H., Zweigenbaum, J., Wang, M., Khan, I.A. Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. food chemistry, 2015, vol. 178, p. 136–148. DOI: 10.1016/j.foodchem.2015.01.053. [DOI link]
Composition #7: Adamczak, Artur., Opala, Bogna., Gryszczynska, Agnieszka., Buchwald, Waldemar. Content of pyrrolizidine alkaloids in the leaves of coltsfoot (Tussilago farfara L.) in Poland . acta societatis botanicorum poloniae, 2013, vol. 82, no. 4, p. 289–293. DOI: 10.5586/asbp.2013.028. [DOI link]
Composition #8: Adamczak, Artur., Opala, Bogna., Gryszczynska, Agnieszka., Buchwald, Waldemar. Content of pyrrolizidine alkaloids in the leaves of coltsfoot (Tussilago farfara L.) in Poland . acta societatis botanicorum poloniae, 2013, vol. 82, no. 4, p. 289–293. DOI: 10.5586/asbp.2013.028. [DOI link]
Composition #9: Adamczak, Artur., Opala, Bogna., Gryszczynska, Agnieszka., Buchwald, Waldemar. Content of pyrrolizidine alkaloids in the leaves of coltsfoot (Tussilago farfara L.) in Poland . acta societatis botanicorum poloniae, 2013, vol. 82, no. 4, p. 289–293. DOI: 10.5586/asbp.2013.028. [DOI link]
Composition #10: Nedelcheva, Anely., Kostova, Nadezhda., Sidjimov, Atanas. Pyrrolizidine alkaloids in Tussilago farfara from Bulgaria. biotechnology & biotechnological equipment, 2015, vol. 29, p. S1–S7. DOI: 10.1080/13102818.2015.1047149. [DOI link]
Composition #11: Smyrska-Wieleba, Natalia., Wojtanowski, Krzysztof Kamil., Mroczek, Tomasz. Comparative HILIC/ESI-QTOF-MS and HPTLC studies of pyrrolizidine alkaloids in flowers of Tussilago farfara and roots of Arnebia euchroma . phytochemistry letters, 2017, vol. 20, p. 339–349. DOI: 10.1016/j.phytol.2016.11.009. [DOI link]
Composition #12: Smyrska-Wieleba, Natalia., Wojtanowski, Krzysztof Kamil., Mroczek, Tomasz. Comparative HILIC/ESI-QTOF-MS and HPTLC studies of pyrrolizidine alkaloids in flowers of Tussilago farfara and roots of Arnebia euchroma . phytochemistry letters, 2017, vol. 20, p. 339–349. DOI: 10.1016/j.phytol.2016.11.009. [DOI link]
Endpoint study #1: Zhang, Yan., Huang, Fang., Wu, Di., Zhang, Mian. Hepatotoxicity of Flos Farfarae and contained alkaloid to mice. shizhen guoyi guoyao, 2008, vol. 19, no. 8, p. 1810–1811. .
Endpoint study #2: Gao, Hong., Huang, Yi-Na., Gao, Bo., Xu, Pei-Yu., Inagaki, Chika., Kawabata, Jun. alpha-Glucosidase inhibitory effect by the flower buds of Tussilago farfara L. . food chemistry, 2008, vol. 106, no. 3, p. 1195–1201. DOI: 10.1016/j.foodchem.2007.07.064. [DOI link]