EFSA Compendium of Botanicals

Draft - work in progress

Turbina corymbosa (L.) Raf. // Rivea corymbosa (L.) Hallier.f.

Family:: Convolvulaceae
Approval state:: Approved
Number of articles retrieved:: 93
Number of processed references:: 3

Compositions

#1: chanoclavine in seeds #2: isoergine in seeds #3: lysergol in seeds #4: ergine in seeds #5: elymoclavine in seeds #6: ergot and clavine type alkaloids in stems #7: ergot and clavine type alkaloids in leaves

Endpoint Studies

#1: hallucinogenic effect 2mg of crude extract of alkaloids from Rivea corymbosa

Genotoxicity

Composition #1: Farnsworth, Norman R. Hallucinogenic plants. science (washington, dc, united states), 1968, vol. 162, no. 3858, p. 1086–92. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Additional extraction description:

unspecified
Substance:

Chanoclavine-1 (RF-00000381-TOX)
Analytical method - additional description:

unspecified
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0005
Internal remarks:

chanoclavine in seeds

Composition #2: Farnsworth, Norman R. Hallucinogenic plants. science (washington, dc, united states), 1968, vol. 162, no. 3858, p. 1086–92. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Additional extraction description:

unspecified
Substance:

Ergine (RF-00000385-TOX)
Additional substance description:

isoergine
Analytical method - additional description:

unspecified
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0020
Internal remarks:

isoergine in seeds

Composition #3: Farnsworth, Norman R. Hallucinogenic plants. science (washington, dc, united states), 1968, vol. 162, no. 3858, p. 1086–92. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Additional extraction description:

unspecified
Substance:

Lysergol (RF-00000408-TOX)
Analytical method - additional description:

unspecified
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0005
Internal remarks:

lysergol in seeds

Composition #4: Farnsworth, Norman R. Hallucinogenic plants. science (washington, dc, united states), 1968, vol. 162, no. 3858, p. 1086–92. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Additional extraction description:

unspecified
Substance:

Ergine (RF-00000385-TOX)
Analytical method - additional description:

unspecified
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0065
Internal remarks:

ergine in seeds

Composition #5: Farnsworth, Norman R. Hallucinogenic plants. science (washington, dc, united states), 1968, vol. 162, no. 3858, p. 1086–92. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Additional extraction description:

unspecified
Substance:

Elymoclavine (RF-00000384-TOX)
Analytical method - additional description:

unspecified
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.0005
Internal remarks:

elymoclavine in seeds

Composition #6: TABER, WA., HEACOCK, RA., MAHON, ME. ERGOT-TYPE ALKALOIDS IN VEGETATIVE TISSUE OF RIVEA-CORYMBOSA (L) HALL F. phytochemistry, 1963, vol. 2, no. 1, p. 99–101. DOI: 10.1016/S0031-9422(00)88021-8. [DOI link]

Language:

English (en)
Plant part:

Stem / stalk (as part-nature) (A067S)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate, ether
Substance:

ergoline alkaloids (RF-00004355-PAR)
Additional substance description:

ergot and clavine type, including ergine (isolysergic acid amide), isoergine (lysergic acid amide), chanoclavine and elymoclavine
Analytical method code:

Fluorimetry, Nephelometry and Polarimetry (F011A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.010-0.012
Internal remarks:

ergot and clavine type alkaloids in stems

Composition #7: TABER, WA., HEACOCK, RA., MAHON, ME. ERGOT-TYPE ALKALOIDS IN VEGETATIVE TISSUE OF RIVEA-CORYMBOSA (L) HALL F. phytochemistry, 1963, vol. 2, no. 1, p. 99–101. DOI: 10.1016/S0031-9422(00)88021-8. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethyl acetate, ether
Substance:

ergoline alkaloids (RF-00004355-PAR)
Additional substance description:

ergot and clavine type, including ergine (isolysergic acid amide), isoergine (lysergic acid amide), chanoclavine and elymoclavine
Analytical method code:

Fluorimetry, Nephelometry and Polarimetry (F011A)
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.016-0.027
Internal remarks:

ergot and clavine type alkaloids in leaves

Endpoint study #1: ISBELL, H., GORODETZKY, CW. EFFECT OF ALKALOIDS OF OLOLIUQUI IN MAN. psychopharmacologia, 1966, vol. 8, no. 5, p. 331–331. .

Study relevance:

Human health
Substance:

lysergic acid (RF-00003915-PAR)
Plant part:

Seed (as part-nature) (A066P)
Additional plant/substance description:

d-lysergic acid arnide, d-iso-lysergic acid amide, and chanoclavine from seeds of Rivea corymbosa
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male
Exposure duration:

1.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

2
Control groups used:

no data
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligram (G155A)
Effect concentration:

2
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

neurologic: Central Nervous System (TT035A)
Effect description:

hallucination dreamy states, with alterations in the perception of colors and objects
Effect or parameter linked to the endpoint:

behaviour (CHD001BE)
Internal remarks:

hallucinogenic effect 2mg of crude extract of alkaloids from Rivea corymbosa