EFSA Compendium of Botanicals

Draft - work in progress

Trichosanthes kirilowii Maxim.

Family:: Cucurbitaceae
Approval state:: Approved
Number of articles retrieved:: 2212
Number of processed references:: 4

Compositions

#1: cucurbitacin B, isocucurbitacin B, cucurbitacin D, isocucurbitacin D, 3-epi-isocucurbitacin B, dihydrocucurbitacin B, dihydroisocucurbitacin B and dihydrocucurbitacin E in roots #2: hanultarin in seeds #3: cucurbitacin B in unspecified part #4: trichosanthin in tubers

Endpoint Studies

Genotoxicity

Composition #1: Ryu, Shi Yong., Lee, Seung Ho., Choi, San Un., Lee, Chong Ock., No, Zaesung., Ahn, Jong Woong. Antitumor activity of Trichosanthes kirilowii. archives of pharmacal research (seoul), 1994, vol. 17, no. 5, p. 348–353. DOI: 10.1007/BF02974175. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol, column chromatography, Preparative TLC
Substance:

cucurbitacin B (RF-00004232-PAR)
Additional substance description:

cucurbitacin B, isocucurbitacin B, cucurbitacin D, isocucurbitacin D, 3-epi-isocucurbitacin B, dihydrocucurbitacin B, dihydroisocucurbitacin B and dihydrocucurbitacin E
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cucurbitacin B, isocucurbitacin B, cucurbitacin D, isocucurbitacin D, 3-epi-isocucurbitacin B, dihydrocucurbitacin B, dihydroisocucurbitacin B and dihydrocucurbitacin E in roots

Composition #2: Lee, Eunyoung., Ahamed, V. S. Jamal., Kumar, Mahto Sanjeev., Rhee, Seog Woo., Moon, Surk-Sik., Hong, In Seok. Synthesis and evaluation of cytotoxic effects of hanultarin and its derivatives . bioorganic & medicinal chemistry letters, 2011, vol. 21, no. 21, p. 6245–6248. DOI: 10.1016/j.bmcl.2011.09.014. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Additional extraction description:

unspecified
Substance:

lignans (RF-00004361-PAR)
Additional substance description:

hanultarin
Analytical method code:

Unspecified (F598A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

hanultarin in seeds

Composition #3: Ding, Xiuli., Chi, Jiadong., Yang, Xue., Hao, Jian., Liu, Chang., Zhu, Cuihong., Wang, Xiaodong., Liu, Xiaohui., Niu, Yangyang., Ji, Wei., Chen, Dan., Wu, Xiongzhi. Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells . leukemia & lymphoma, 2017, vol. 58, no. 10, p. 2439–2451. DOI: 10.1080/10428194.2017.1289521. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Dichloromethane extract
Substance:

cucurbitacin B (RF-00004232-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cucurbitacin B in unspecified part

Composition #4: CHAN, WY., NG, TB., WU, PJ., YEUNG, HW. DEVELOPMENTAL TOXICITY AND TERATOGENICITY OF TRICHOSANTHIN, A RIBOSOME-INACTIVATING PROTEIN, IN MICE . teratogenesis carcinogenesis and mutagenesis, 1993, vol. 13, no. 2, p. 47–57. DOI: 10.1002/tcm.1770130202. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

acetone
Substance:

trichosanthin (RF-00003610-PAR)
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

trichosanthin in tubers