EFSA Compendium of Botanicals

Draft - work in progress

Thymus zygis L.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 200
Number of processed references:: 4

Compositions

#1: Myrcene in aerial parts #2: Camphor in aerial parts #3: myrcene in aerial parts #4: 1,8-cineole in aerial parts #5: Fenchone #6: pulegone #7: myrcene #8: p-coumaric acid in aerial part #9: Protocatechuic acid in aerial part #10: p-Hydroxybenzoic acid in aerial part

Endpoint Studies

Genotoxicity

Composition #1: Gómez, P.S., Sánchez, J.A.S., Cano, M.C.S., Castellanos, E.C., García Vallejo, M.C. Chemical composition of the essential oil of Thymus zygis ssp. Gracilis c.v. “Linalool type,” and its performance under cultivation. journal of essential oil research, 1995, vol. 7, no. 4, p. 399–402. DOI: 10.1080/10412905.1995.9698547. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

8.5-10.0
Internal remarks:

Myrcene in aerial parts

Composition #2: da Cunha, A.P., Salgueiro, L.R. The chemical polymorphism of Thymus zygis ssp. sylvestris from central portugal. journal of essential oil research, 1991, vol. 3, no. 6, p. 409–412. DOI: 10.1080/10412905.1991.9697975. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-FID (F040A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<= 3.9
Internal remarks:

Camphor in aerial parts

Composition #3: da Cunha, A.P., Salgueiro, L.R. The chemical polymorphism of Thymus zygis ssp. sylvestris from central portugal. journal of essential oil research, 1991, vol. 3, no. 6, p. 409–412. DOI: 10.1080/10412905.1991.9697975. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-FID (F040A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<= 2
Internal remarks:

myrcene in aerial parts

Composition #4: da Cunha, A.P., Salgueiro, L.R. The chemical polymorphism of Thymus zygis ssp. sylvestris from central portugal. journal of essential oil research, 1991, vol. 3, no. 6, p. 409–412. DOI: 10.1080/10412905.1991.9697975. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-FID (F040A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

<= 20
Internal remarks:

1,8-cineole in aerial parts

Composition #5: De Lisi, Antonino., Tedone, Luigi., Montesano, Vincenzo., Sarli, Giulio., Negro, Donatella. Chemical characterisation of Thymus populations belonging from Southern Italy . food chemistry, 2011, vol. 125, no. 4, p. 1284–1286. DOI: 10.1016/j.foodchem.2010.10.011. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrodistilation
Substance:

fenchone (RF-00003814-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.35
Internal remarks:

Fenchone

Composition #6: De Lisi, Antonino., Tedone, Luigi., Montesano, Vincenzo., Sarli, Giulio., Negro, Donatella. Chemical characterisation of Thymus populations belonging from Southern Italy . food chemistry, 2011, vol. 125, no. 4, p. 1284–1286. DOI: 10.1016/j.foodchem.2010.10.011. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrodistilation
Substance:

(+)-pulegone (RF-00003398-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.4
Internal remarks:

pulegone

Composition #7: De Lisi, Antonino., Tedone, Luigi., Montesano, Vincenzo., Sarli, Giulio., Negro, Donatella. Chemical characterisation of Thymus populations belonging from Southern Italy . food chemistry, 2011, vol. 125, no. 4, p. 1284–1286. DOI: 10.1016/j.foodchem.2010.10.011. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hydrodistilation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.18
Internal remarks:

myrcene

Composition #8: Rubio, Laura., Serra, Aida., Macia, Alba., Borras, Xenia., Romero, Maria-Paz., Motilva, Maria-Jose. Validation of determination of plasma metabolites derived from thyme bioactive compounds by improved liquid chromatography coupled to tandem mass spectrometry . journal of chromatography b-analytical technologies in the biomedical and life sciences, 2012, vol. 905, p. 75–84. DOI: 10.1016/j.jchromb.2012.07.040. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH-water
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

HPLC-MS/MS (F698A)
Result unit:

Millimole/kilogram (G070A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.4
Internal remarks:

p-coumaric acid in aerial part

Composition #9: Rubio, Laura., Serra, Aida., Macia, Alba., Borras, Xenia., Romero, Maria-Paz., Motilva, Maria-Jose. Validation of determination of plasma metabolites derived from thyme bioactive compounds by improved liquid chromatography coupled to tandem mass spectrometry . journal of chromatography b-analytical technologies in the biomedical and life sciences, 2012, vol. 905, p. 75–84. DOI: 10.1016/j.jchromb.2012.07.040. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH-water
Substance:

3,4-Dihydroxybenzoic acid (RF-00008853-PAR)
Additional substance description:

Protocatechuic acid
Analytical method code:

HPLC-MS/MS (F698A)
Result unit:

Millimole/kilogram (G070A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.8
Internal remarks:

Protocatechuic acid in aerial part

Composition #10: Rubio, Laura., Serra, Aida., Macia, Alba., Borras, Xenia., Romero, Maria-Paz., Motilva, Maria-Jose. Validation of determination of plasma metabolites derived from thyme bioactive compounds by improved liquid chromatography coupled to tandem mass spectrometry . journal of chromatography b-analytical technologies in the biomedical and life sciences, 2012, vol. 905, p. 75–84. DOI: 10.1016/j.jchromb.2012.07.040. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

EtOH-water
Substance:

4-Hydroxybenzoic acid (RF-00008325-PAR)
Analytical method code:

HPLC-MS/MS (F698A)
Result unit:

Millimole/kilogram (G070A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.85
Internal remarks:

p-Hydroxybenzoic acid in aerial part