EFSA Compendium of Botanicals

Draft - work in progress

Common thyme (as plant) // Thymus vulgaris L.

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 4358
Number of processed references:: 3

Compositions

#1: 1,8-cineole in leaves #2: myrcene in leaves #3: myrcene in unspecified part

Endpoint Studies

Genotoxicity

Composition #1: Demirel, N., Sener, O., Arslan, M., Uremis, I., Uluc, F. T., Cabuk, F. Toxicological Responses of Confused Flour Beetle, Tribolium confusum du Val (Coleoptera: Tenebrinoidea) to Various Plant Essential Oils . asian journal of chemistry, 2009, vol. 21, no. 8, p. 6403–6410. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

sodium-sulfate
Substance:

1,8-cineole (RF-00003470-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.40
Internal remarks:

1,8-cineole in leaves

Composition #2: Demirel, N., Sener, O., Arslan, M., Uremis, I., Uluc, F. T., Cabuk, F. Toxicological Responses of Confused Flour Beetle, Tribolium confusum du Val (Coleoptera: Tenebrinoidea) to Various Plant Essential Oils . asian journal of chemistry, 2009, vol. 21, no. 8, p. 6403–6410. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

sodium-sulfate
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.11
Internal remarks:

myrcene in leaves

Composition #3: ZANI, F., MASSIMO, G., BENVENUTI, S., BIANCHI, A., ALBASINI, A., MELEGARI, M., VAMPA, G., BELLOTTI, A., MAZZA, P. STUDIES ON THE GENOTOXIC PROPERTIES OF ESSENTIAL OILS WITH BACILLUS-SUBTILIS REC-ASSAY AND SALMONELLA MICROSOME REVERSION ASSAY . planta medica, 1991, vol. 57, no. 3, p. 237–241. DOI: 10.1055/s-2006-960081. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Additional extraction description:

unspecified
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

Unspecified (F598A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.02
Internal remarks:

myrcene in unspecified part

Endpoint study #1: Yürüktümen, A., Hocaoglu, N., Ersel, M., Özsaraç, M., Kiyan, S. Acute hepatitis associated with Thymus Vulgaris oil ingestion: Case report. turkiye acil tip dergisi, 2011, vol. 11, no. 2, p. 68–71. DOI: 10.5505/1304.7361.2011.79664. [DOI link]

Study relevance:

Human health
Plant part:

Unspecified (A07XD)
Preparation/Extraction method:

Essential oil (as part-nature) (A166Q)
Type of toxicological test:

case report (CHD060TT)
Limit test:

Not applicable
Tested organism:

Human (as organism) (A056J)
Sex:

Male
Route of exposure:

ORAL: DRINKING WATER (OECD2229PL)
Number of organisms dosed:

1
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Millilitre (G156A)
Effect concentration:

25
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

Digestive (TT002A)
Effect description:

nausea, vomiting and diarrhea, and high transaminase levels
Effect or parameter linked to the endpoint:

other (CHD003BE)
Internal remarks:

toxic hepatitis in human