EFSA Compendium of Botanicals

Draft - work in progress

Tanacetum parthenium (L.) Sch.Bip. // Chrysanthemum parthenium (L.) Bernh.

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 1635
Number of processed references:: 5

Compositions

#1: Camphor in essential oil of leaves, buds and flowers #2: tannins in aerial parts #3: alkaloids in aerial parts #4: saponins in aerial parts #5: parthenolide in plant material #6: costunolide in flower #7: parhenolide in flower #8: costunolide in leaves #9: parhenolide in leaves #10: Camphor in flowers #11: Camphor in leaves

Endpoint Studies

#1: Hepatotoxicity caused by ethanolic extract of aerial parts

Genotoxicity

Composition #1: Hendriks, H., Bos, R., Woerdenbag, H. J. The essential oil of Tanacetum parthenium (L.) Schultz-Bip. flavour and fragrance journal, 1996, vol. 11, no. 6, p. 367–371. DOI: 10.1002/(SICI)1099-1026(199611)11:6<367::AID-FFJ598>3.0.CO;2-R. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation (leaves, buds and flowers)
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

28.0- 47.5
Internal remarks:

Camphor in essential oil of leaves, buds and flowers

Composition #2: Enciso-Roca, E., Aguilar-Felices, E.J., Tinco-Jayo, J.A., Arroyo-Acevedo, J.L., Herrera-Calderon, O., Aguilar-Carranza, C., Justil-Guerrero, H. Effects of acute and sub-acute oral toxicity studies of ethanol extract of Tanacetum parthenium (L) Sch. Bip. Aerial parts in mice and rats. annual research and review in biology, 2017, vol. 19, no. 2 . DOI: 10.9734/ARRB/2017/37326. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 96%
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tannins in aerial parts

Composition #3: Enciso-Roca, E., Aguilar-Felices, E.J., Tinco-Jayo, J.A., Arroyo-Acevedo, J.L., Herrera-Calderon, O., Aguilar-Carranza, C., Justil-Guerrero, H. Effects of acute and sub-acute oral toxicity studies of ethanol extract of Tanacetum parthenium (L) Sch. Bip. Aerial parts in mice and rats. annual research and review in biology, 2017, vol. 19, no. 2 . DOI: 10.9734/ARRB/2017/37326. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 96%
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

alkaloids in aerial parts

Composition #4: Enciso-Roca, E., Aguilar-Felices, E.J., Tinco-Jayo, J.A., Arroyo-Acevedo, J.L., Herrera-Calderon, O., Aguilar-Carranza, C., Justil-Guerrero, H. Effects of acute and sub-acute oral toxicity studies of ethanol extract of Tanacetum parthenium (L) Sch. Bip. Aerial parts in mice and rats. annual research and review in biology, 2017, vol. 19, no. 2 . DOI: 10.9734/ARRB/2017/37326. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol 96%
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saponins in aerial parts

Composition #5: Salama, R., Sattayasai, J., Gande, A K., Sattayasai, N., Davis, M., Lattmann, E. Identification and evaluation of agents isolated from traditionally used herbs against Ophiophagus hannah venom. . drug discoveries & therapeutics, 2012, vol. 6, no. 1, p. 18–23. .

Language:

English (en)
Plant part:

Unspecified (A07XD)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

chloroform
Substance:

parthenolide (RF-00003531-PAR)
Analytical method code:

Chromatographic tests (F015A)
Analytical method - additional description:

TLC analysis
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

parthenolide in plant material

Composition #6: Majdi, Mohammad., Charnikhova, Tatsiana., Bouwmeester, Harro. Genetical, developmental and spatial factors influencing parthenolide and its precursor costunolide in feverfew (Tanacetum parthenium L. Schulz Bip.) . industrial crops and products, 2013, vol. 47, p. 270–276. DOI: 10.1016/j.indcrop.2013.03.021. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol: formic acid
Substance:

costunolide (RF-00003753-PAR)
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

liquid chromatography coupled to tandem mass spectrometry (UPLC–MS/MS)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

costunolide in flower

Composition #7: Majdi, Mohammad., Charnikhova, Tatsiana., Bouwmeester, Harro. Genetical, developmental and spatial factors influencing parthenolide and its precursor costunolide in feverfew (Tanacetum parthenium L. Schulz Bip.) . industrial crops and products, 2013, vol. 47, p. 270–276. DOI: 10.1016/j.indcrop.2013.03.021. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol: formic acid
Substance:

parthenolide (RF-00003531-PAR)
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

liquid chromatography coupled to tandem mass spectrometry (UPLC–MS/MS)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

parhenolide in flower

Composition #8: Majdi, Mohammad., Charnikhova, Tatsiana., Bouwmeester, Harro. Genetical, developmental and spatial factors influencing parthenolide and its precursor costunolide in feverfew (Tanacetum parthenium L. Schulz Bip.) . industrial crops and products, 2013, vol. 47, p. 270–276. DOI: 10.1016/j.indcrop.2013.03.021. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol: formic acid
Substance:

costunolide (RF-00003753-PAR)
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

liquid chromatography coupled to tandem mass spectrometry (UPLC–MS/MS)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

costunolide in leaves

Composition #9: Majdi, Mohammad., Charnikhova, Tatsiana., Bouwmeester, Harro. Genetical, developmental and spatial factors influencing parthenolide and its precursor costunolide in feverfew (Tanacetum parthenium L. Schulz Bip.) . industrial crops and products, 2013, vol. 47, p. 270–276. DOI: 10.1016/j.indcrop.2013.03.021. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol: formic acid
Substance:

parthenolide (RF-00003531-PAR)
Analytical method code:

LC-MS (F026A)
Analytical method - additional description:

liquid chromatography coupled to tandem mass spectrometry (UPLC–MS/MS)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

parhenolide in leaves

Composition #10: Vegh, Krisztina., Riethmuller, Eszter., Toth, Anita., Alberti, Agnes., Beni, Szabolcs., Balla, Jozsef., Kery, Agnes. Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L. . biomedical chromatography, 2016, vol. 30, no. 12, p. 2031–2037. DOI: 10.1002/bmc.3781. [DOI link]

Language:

English (en)
Plant part:

Flower (as part-nature) (A067B)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

Ultra Performance Convergence Chromatography
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

148.4- 187.6
Internal remarks:

Camphor in flowers

Composition #11: Vegh, Krisztina., Riethmuller, Eszter., Toth, Anita., Alberti, Agnes., Beni, Szabolcs., Balla, Jozsef., Kery, Agnes. Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L. . biomedical chromatography, 2016, vol. 30, no. 12, p. 2031–2037. DOI: 10.1002/bmc.3781. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Camphor (RF-00003986-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

Ultra Performance Convergence Chromatography
Result unit:

Milligram/gram (G060A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

247.6- 324.8
Internal remarks:

Camphor in leaves

Endpoint study #1: Enciso-Roca, E., Aguilar-Felices, E.J., Tinco-Jayo, J.A., Arroyo-Acevedo, J.L., Herrera-Calderon, O., Aguilar-Carranza, C., Justil-Guerrero, H. Effects of acute and sub-acute oral toxicity studies of ethanol extract of Tanacetum parthenium (L) Sch. Bip. Aerial parts in mice and rats. annual research and review in biology, 2017, vol. 19, no. 2 . DOI: 10.9734/ARRB/2017/37326. [DOI link]

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

ethanol 96%
Type of toxicological test:

short-term toxicity (CHD017TT)
Tested organism:

Rat (as animal) (A0CNV)
Sex:

Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

28.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

10
Control groups used:

yes, concurrent no treatment
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

500
Critical effect:

HEPATOTOXICITY (TOX02A)
Target tissue:

digestive: Liver (TT023A)
Effect description:

Micro-vesicular steatosis, congestion in centrilobular vein, portal space with slight infiltrated inflammatory cells at dose of 500 mg/kg and 1000 mg/Kg.
Effect or parameter linked to the endpoint:

histopathology non neoplastic (CHD025BE)
Internal remarks:

Hepatotoxicity caused by ethanolic extract of aerial parts