EFSA Compendium of Botanicals

Draft - work in progress

Tagetes lucida Cav. // Tagetes florida Sweet

Family:: Asteraceae
Approval state:: Approved
Number of articles retrieved:: 114
Number of processed references:: 4

Compositions

#1: 6,7-dimethoxycoumarin in leaves #2: 7-methoxycoumarin in leaves #3: Estragole in aerial parts #4: Methylisoeugenol in aerial parts #5: Methyleugenol in aerial parts #6: Myrcene in aerial parts #7: methyleugenol in essential oil from leaves

Endpoint Studies

#1: Effect on sperm quality in rats following intake of methanolic extract

Genotoxicity

Composition #1: Mejia-Barajas, J.A., Del Rio, R.E.N., Martinez-Muñoz, R.E., Flores-Garcia, A., Martinez-Pacheco, M.M. Cytotoxic activity in Tagetes lucida Cav.. emirates journal of food and agriculture, 2012, vol. 24, no. 2, p. 142–147. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

scoparone (RF-00004047-PAR)
Additional substance description:

6,7-dimethoxy-coumarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

6,7-dimethoxycoumarin in leaves

Composition #2: Mejia-Barajas, J.A., Del Rio, R.E.N., Martinez-Muñoz, R.E., Flores-Garcia, A., Martinez-Pacheco, M.M. Cytotoxic activity in Tagetes lucida Cav.. emirates journal of food and agriculture, 2012, vol. 24, no. 2, p. 142–147. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

hexane
Substance:

herniarin (RF-00010991-PAR)
Additional substance description:

7-methoxycoumarin
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

7-methoxycoumarin in leaves

Composition #3: Bicchi, Carlo., Fresia, Monica., Rubiolo, Patrizia., Monti, Diego., Franz, Chlodwig., Goehler, Irina. Constituents of Tagetes lucida Cav. ssp lucida Essential Oil. flavour and fragrance journal, 1997, vol. 12, no. 1, p. 47–52. DOI: 10.1002/(SICI)1099-1026(199701)12:1<47::AID-FFJ610>3.0.CO;2-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Estragole (RF-00003806-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

33.9
Internal remarks:

Estragole in aerial parts

Composition #4: Bicchi, Carlo., Fresia, Monica., Rubiolo, Patrizia., Monti, Diego., Franz, Chlodwig., Goehler, Irina. Constituents of Tagetes lucida Cav. ssp lucida Essential Oil. flavour and fragrance journal, 1997, vol. 12, no. 1, p. 47–52. DOI: 10.1002/(SICI)1099-1026(199701)12:1<47::AID-FFJ610>3.0.CO;2-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

methylisoeugenol (RF-00003493-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

2.0
Internal remarks:

Methylisoeugenol in aerial parts

Composition #5: Bicchi, Carlo., Fresia, Monica., Rubiolo, Patrizia., Monti, Diego., Franz, Chlodwig., Goehler, Irina. Constituents of Tagetes lucida Cav. ssp lucida Essential Oil. flavour and fragrance journal, 1997, vol. 12, no. 1, p. 47–52. DOI: 10.1002/(SICI)1099-1026(199701)12:1<47::AID-FFJ610>3.0.CO;2-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

24.3
Internal remarks:

Methyleugenol in aerial parts

Composition #6: Bicchi, Carlo., Fresia, Monica., Rubiolo, Patrizia., Monti, Diego., Franz, Chlodwig., Goehler, Irina. Constituents of Tagetes lucida Cav. ssp lucida Essential Oil. flavour and fragrance journal, 1997, vol. 12, no. 1, p. 47–52. DOI: 10.1002/(SICI)1099-1026(199701)12:1<47::AID-FFJ610>3.0.CO;2-7. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

myrcene (RF-00003503-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.3
Internal remarks:

Myrcene in aerial parts

Composition #7: Marotti, M., Piccaglia, R., Biavati, B., Marotti, H. Characterization and yield evaluation of essential oils from different Tagetes species . journal of essential oil research, 2004, vol. 16, no. 5, p. 440–444. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

steam distillation
Substance:

methyleugenol (RF-00003931-PAR)
Analytical method code:

GC-FID (F040A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.6
Internal remarks:

methyleugenol in essential oil from leaves

Endpoint study #1: Téllez-López, M.A., Treviño-Neávez, J.F., Verde-Star, M.J., Rivas-Morales, C., Oranday-Cárdenas, A., Moran-Martínez, J., Serrano-Gallardo, L.B., Morales-Rubio, M.E. Evaluation of the e!ect of methanol extract of Tagetes lucida on testicular function and sperm quality in male Wistar rats Evaluación del efecto del extracto metanólico de Tagetes lucida sobre la función testicular y calidad espermática en ratas macho Wistar . revista mexicana de ciencias farmaceuticas, 2013, vol. 44, no. 4, p. 43–52. .

Study relevance:

Human health
Plant part:

Aerial part of plants (as part-nature) (A166F)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol
Type of toxicological test:

subchronic (CHD013TT)
Tested organism:

Rat (as animal) (A0CNV)
Strain of test organism:

Wistar (CHD013ST)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

45.0
Unit of exposure duration:

Day (G134A)
Number of organisms dosed:

5
Control groups used:

yes, concurrent vehicle
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

50
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

urogenital: Testes (TT050A)
Effect description:

Lowered sperm motility and density, lowered number of living sperm and increased number of DNA strand breaks in sperm.
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

Effect on sperm quality in rats following intake of methanolic extract