EFSA Compendium of Botanicals

Draft - work in progress

Strychnos toxifera R.H.Schomb. ex Lindl.

Family:: Loganiaceae
Approval state:: Approved
Number of articles retrieved:: 49
Number of processed references:: 5

Compositions

#1: Curare alkaloids in bark #2: toxiferine derivatives in bark #3: Curare alkaloids in bark #4: Curare alkaloids from unspecified plant parts #5: Curare alkaloids in bark

Endpoint Studies

Genotoxicity

Composition #1: Battersby, A.R., Binks, R., Hodson, H.F., Yeowell, D.A. 368. Alkaloids of calabash-curare and strychnos species. Part II. Isolation of new alkaloids. journal of the chemical society (resumed), 1960, p. 1848–1854. .

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

curare alkaloids (hemitoxiferine-I, macusine-A and B, xanthocurine)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Curare alkaloids in bark

Composition #2: KING, H. CURARE ALKALOIDS .10. SOME ALKALOIDS OF STRYCHNOS TOXIFERA ROB - SCHOMB. journal of the chemical society, 1949, no. DEC, p. 3263–3271. DOI: 10.1039/jr9490003263. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

toxiferine (RF-00003608-PAR)
Additional substance description:

toxiferine derivatives (several derivatives)
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

toxiferine derivatives in bark

Composition #3: ASMIS, H., SCHMID, H., KARRER, P. CURARE-ALKALOIDE AUS CALEBASSEN UND VERWANDTE VERBINDUNGEN .13. UBER ALKALOIDE AUS EINER STRYCHNOS-TOXIFERA-RINDE AUS VENEZUELA . helvetica chimica acta, 1954, vol. 37, no. 7, p. 1983–1992. DOI: 10.1002/hlca.19540370710. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

mavacurine, fluorocurine, caracurines I-VII
Analytical method code:

Chromatographic tests (F015A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Curare alkaloids in bark

Composition #4: BERNAUER, K., BERLAGE, F., VONPHILIPSBORN, W., SCHMID, H., KARRER, P. UBER DIE KONSTITUTION DER CALEBASSEN-ALKALOIDE C-DIHYDRO-TOXIFERIN UND C-TOXIFERIN-I UND DES ALKALOIDS CARACURIN-V AUS STRYCHNOS-TOXIFERA - SYNTHETISCHE VERSUCHE MIT WIELAND-GUMLICH-ALDEHYD ALS AUSGANGSSTOFF .36. CALEBASSEN-ALKALOIDE . helvetica chimica acta, 1958, vol. 41, no. 7, p. 2293–2208. DOI: 10.1002/hlca.19580410741. [DOI link]

Language:

English (en)
Plant part:

Unspecified (A07XD)
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

Curare alkaloids (Caracurin V, C-Toxiferin I)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Curare alkaloids from unspecified plant parts

Composition #5: QUETINLECLERCQ, J., ANGENOT, L., DUPONT, L., BISSET, NG. ISOLATION AND PURIFICATION OF PANARINE, AN ALKALOID FROM A VENEZUELAN CURARE . phytochemistry, 1988, vol. 27, no. 12, p. 4002–4004. DOI: 10.1016/0031-9422(88)83075-9. [DOI link]

Language:

English (en)
Plant part:

Bark (as part-nature) (A066X)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water and acetic acid
Substance:

indole alkaloids (RF-00004503-PAR)
Additional substance description:

macusine B and panarine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Curare alkaloids in bark