EFSA
ecomole
vscht
  2. Strychnos nux-vomica L.

Strychnos nux-vomica L.

Family:
Loganiaceae
Approval state:
Approved
Number of articles retrieved:
1030
Number of processed references:
9
Compositions
#1: Icajine in seeds #2: Indole alkaloids (14 strychnine derivatives) in seeds #3: beta-colubrine in seeds #4: brucine in seeds #5: alpha-colubrine in seeds #6: strychnine in seeds #7: vomicine in seeds #8: novacine in seeds #9: Brucine in seeds #10: Strychnine in seeds
Endpoint Studies
#1: Case report of neurological and musculo-skeletal effects in a healthy human male who consumed the leaves #2: Mortality (LD50) in mice #3: Case report (muscle spasms and hypertonic crisis with respiratory blocking) after ingestion of 3.5 mg strychnine per kg b.w. #4: Neurological and nephrotoxic effects in accidental poisoning with decoction of seeds #5: Neurologic and nephrotoxic effects of decoction of bracts in female case #6: Mortality in children after consumption of decoction from bark #7: Neurologic effects in case report of poisoning of three persons with decoction of bark #8: Nephrotoxic effects (due to rhabdmyolysis) in case report of poisoning of one person with decoction of bark #9: Mortality (neurotoxicity, renal failure reported) from accidental decoction of bark
Genotoxicity
Composition #1: Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. rsc advances, 2015, vol. 5, no. 95, p. 77689–77698. .
Composition #2: Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. rsc advances, 2015, vol. 5, no. 95, p. 77689–77698. .
Composition #3: Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. rsc advances, 2015, vol. 5, no. 95, p. 77689–77698. .
Composition #4: Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. rsc advances, 2015, vol. 5, no. 95, p. 77689–77698. .
Composition #5: Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. rsc advances, 2015, vol. 5, no. 95, p. 77689–77698. .
Composition #6: Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. rsc advances, 2015, vol. 5, no. 95, p. 77689–77698. .
Composition #7: Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. rsc advances, 2015, vol. 5, no. 95, p. 77689–77698. .
Composition #8: Li, Shujuan., Zhang, Meiyu., Hou, Pengyi., Zhang, Ruowen., Hou, Chenzhi., Bi, Kaishun., Chen, Xiaohui. Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. rsc advances, 2015, vol. 5, no. 95, p. 77689–77698. .
Composition #9: Anwar, Noman., Khan, Masood Shah., Kabir, Hifzul., Ahmad, Sayeed. Effect of detoxification (tadbeer) in content of toxic metabolites of Strychnos nux-vomica: A Unani approach for its use in human . journal of pharmacy and bioallied sciences, 2015, vol. 7, no. 4, p. 314–316. DOI: 10.4103/0975-7406.168034. [DOI link]
Composition #10: Anwar, Noman., Khan, Masood Shah., Kabir, Hifzul., Ahmad, Sayeed. Effect of detoxification (tadbeer) in content of toxic metabolites of Strychnos nux-vomica: A Unani approach for its use in human . journal of pharmacy and bioallied sciences, 2015, vol. 7, no. 4, p. 314–316. DOI: 10.4103/0975-7406.168034. [DOI link]
Endpoint study #1: Dasari, Sowjanya., Naha, Kushal. A rare case of strychnine poisoning by consumption of Strychnos nux-vomica leaves . asian pacific journal of tropical biomedicine, 2011, vol. 1, no. 2, p. S303–S304. .
Endpoint study #2: Gopalkrishna, S.V., Lakshminarsu, M., Ramachandra Setty, S. Effect of purification (sodhana) on the acute toxicity of seeds of nux-vomica. pharmacologyonline, 2009, vol. 3, p. 1015–1024. .
Endpoint study #3: Gicquel, T., Lepage, S., Baert, A., Morel, I. Case report: Concerning strychnine poisoning by Nux vomica mother tincture Cas clinique: À propos d'une intoxication à la strychnine par la teinture mère Nux vomica . annales de toxicologie analytique, 2012, vol. 24, no. 1, p. 33–37. DOI: 10.1051/ata/2011134. [DOI link]
Endpoint study #4: Karthik Rao, N., Nayak, V.C., James, R.I., Patil, N., Rao, R., Jaunky, C., Ahmed, T. Survival after strychnine poisoning: A case report. research journal of pharmaceutical, biological and chemical sciences, 2016, vol. 7, no. 1, p. 1769–1771. .
Endpoint study #5: Kidiyoor, Y., Rai, S., Bakkannavar, S.M., Nayak, V.C., James, R.I., Saravu, K. Rhabdomyolysis and strychnine poisoning: A case report. research journal of pharmaceutical, biological and chemical sciences, 2016, vol. 7, no. 6, p. 45–47. .
Endpoint study #6: Naik, B Sadananda., Chakrapani, M. A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure. . the malaysian journal of pathology, 2009, vol. 31, no. 1, p. 67–9. .
Endpoint study #7: Naik, B Sadananda., Chakrapani, M. A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure. . the malaysian journal of pathology, 2009, vol. 31, no. 1, p. 67–9. .
Endpoint study #8: Naik, B Sadananda., Chakrapani, M. A rare case of brucine poisoning complicated by rhabdomyolysis and acute renal failure. . the malaysian journal of pathology, 2009, vol. 31, no. 1, p. 67–9. .
Endpoint study #9: Achappa, Basavaprabhu., Madi, Deepak., Babu, Y P Raghavendra., Mahalingam, Soundarya. Rituals can kill - A fatal case of brucine poisoning.. the australasian medical journal, 2012, vol. 5, no. 8, p. 421–3. .