EFSA Compendium of Botanicals

Draft - work in progress

Strophanthus hispidus DC.

Family:: Apocynaceae
Approval state:: Approved
Number of articles retrieved:: 58
Number of processed references:: 5

Compositions

#1: Strophanthidin in seeds #2: Cymarin in seeds #3: Cyanogenic glycosides in leaves #4: Cardiac glycosides in leaves #5: Alkaloids in leaves #6: Saponins in leaves #7: Anthraquinones in roots #8: Cardiac glycosides in roots #9: Tannins in roots #10: Alkaloids in roots #11: Anthraquinones in roots #12: Cardiac glycosides in roots #13: Tannins in roots #14: Cardenolide glycosides in seeds

Endpoint Studies

Genotoxicity

Composition #1: Jacobs, Walter A., Hoffmann, Alexander. Strophanthin. XV. Hispidus strophanthin. journal of biological chemistry, 1928, vol. 79, p. 531–7. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% alcohol at room temp
Substance:

K-strophanthidin (RF-00003466-PAR)
Additional substance description:

after hydrolyzation
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Strophanthidin in seeds

Composition #2: Jacobs, Walter A., Hoffmann, Alexander. Strophanthin. XV. Hispidus strophanthin. journal of biological chemistry, 1928, vol. 79, p. 531–7. .

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

70% alcohol at room temp
Substance:

cymarin (RF-00003761-PAR)
Analytical method code:

Traditional analytical techniques (wet chemical tests) (F003A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cymarin in seeds

Composition #3: Ojiako, O.A., Igwe, C.U. A time-trend hypoglycemic study of ethanol and chloroform extracts of strophanthus hispidus. journal of herbs, spices and medicinal plants, 2009, vol. 15, no. 1, p. 1–8. DOI: 10.1080/10496470902787386. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol or chloroform
Substance:

Cyanogenic glycosides (RF-00004375-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cyanogenic glycosides in leaves

Composition #4: Ojiako, O.A., Igwe, C.U. A time-trend hypoglycemic study of ethanol and chloroform extracts of strophanthus hispidus. journal of herbs, spices and medicinal plants, 2009, vol. 15, no. 1, p. 1–8. DOI: 10.1080/10496470902787386. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol or chloroform
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides in leaves

Composition #5: Ojiako, O.A., Igwe, C.U. A time-trend hypoglycemic study of ethanol and chloroform extracts of strophanthus hispidus. journal of herbs, spices and medicinal plants, 2009, vol. 15, no. 1, p. 1–8. DOI: 10.1080/10496470902787386. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol or chloroform
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in leaves

Composition #6: Ojiako, O.A., Igwe, C.U. A time-trend hypoglycemic study of ethanol and chloroform extracts of strophanthus hispidus. journal of herbs, spices and medicinal plants, 2009, vol. 15, no. 1, p. 1–8. DOI: 10.1080/10496470902787386. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

95% ethanol or chloroform
Substance:

Saponins (RF-00004333-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saponins in leaves

Composition #7: Agbaje, E.O., Fageyinbo, M.S. Evaluating anti-Inflammatory activity of aqueous root extract of Strophanthus hispidus DC. (Apocynaceae). international journal of applied research in natural products, 2011, vol. 4, no. 4, p. 7–14. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

boiling distilled water
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones in roots

Composition #8: Agbaje, E.O., Fageyinbo, M.S. Evaluating anti-Inflammatory activity of aqueous root extract of Strophanthus hispidus DC. (Apocynaceae). international journal of applied research in natural products, 2011, vol. 4, no. 4, p. 7–14. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

boiling distilled water
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides in roots

Composition #9: Agbaje, E.O., Fageyinbo, M.S. Evaluating anti-Inflammatory activity of aqueous root extract of Strophanthus hispidus DC. (Apocynaceae). international journal of applied research in natural products, 2011, vol. 4, no. 4, p. 7–14. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

boiling distilled water
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in roots

Composition #10: Oluwatoyin, A., Samuel, F.M. Anti-nociceptive activity of fractionated root extract of strophanthus hispidus DC (Apocynaceae). journal of natural remedies, 2014, vol. 14, no. 2, p. 164–173. DOI: 10.18311/jnr/2014/78. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water extract; ethyl acetate fraction
Substance:

Alkaloids (RF-00004360-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Alkaloids in roots

Composition #11: Oluwatoyin, A., Samuel, F.M. Anti-nociceptive activity of fractionated root extract of strophanthus hispidus DC (Apocynaceae). journal of natural remedies, 2014, vol. 14, no. 2, p. 164–173. DOI: 10.18311/jnr/2014/78. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water extract, ethyl acetate, aqueous, and n-butanol fractions
Substance:

anthraquinones (RF-00004343-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Anthraquinones in roots

Composition #12: Oluwatoyin, A., Samuel, F.M. Anti-nociceptive activity of fractionated root extract of strophanthus hispidus DC (Apocynaceae). journal of natural remedies, 2014, vol. 14, no. 2, p. 164–173. DOI: 10.18311/jnr/2014/78. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water extract, ethyl acetate, aqueous, and n-butanol fractions
Substance:

cardiac glycosides (RF-00010823-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardiac glycosides in roots

Composition #13: Oluwatoyin, A., Samuel, F.M. Anti-nociceptive activity of fractionated root extract of strophanthus hispidus DC (Apocynaceae). journal of natural remedies, 2014, vol. 14, no. 2, p. 164–173. DOI: 10.18311/jnr/2014/78. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water extract, aqueous and n-butanol fractions
Substance:

Tannins (RF-00004337-PAR)
Analytical method code:

Phytochemical screening (F604A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Tannins in roots

Composition #14: KARTNIG, T., DANHOFER, R. A METHOD FOR IDENTIFICATION AND QUANTITATIVE ANALYSIS OF STROPHANTHUS GLYCOSIDES . journal of chromatography, 1970, vol. 52, no. 2, p. 313–&. DOI: 10.1016/S0021-9673(01)96578-1. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

ethanol
Substance:

cardenolide glycosides cardenolide glycosides (RF-00004348-PAR)
Additional substance description:

K-strophantoside, erysimoside, helveticoside, G-strophanthin and K-strophanthin
Analytical method code:

Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Cardenolide glycosides in seeds