EFSA Compendium of Botanicals

Draft - work in progress

Stephania sinica Diels

Family:: Menispermaceae
Approval state:: Approved
Number of articles retrieved:: 152
Number of processed references:: 3

Compositions

#1: tetrahydropalmatine in roots #2: sinomenine in roots #3: cepharanthine in roots #4: runanine in roots

Endpoint Studies

#1: nausea, vomiting, abdominal pain, diarrhea

Genotoxicity

Composition #1: Nguyen, Quoc Huy., Pham, Thanh Ky. L-Tetrahydropalmatine and sinomenine from Vietnamese Stephania sinica (Diels.) grown in Quang Binh Province. tap chi duoc hoc, 2008, vol. 48, no. 12, p. 21–23. .

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Substance:

palmatine (RF-00003971-PAR)
Additional substance description:

tetrahydropalmatine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

tetrahydropalmatine in roots

Composition #2: Nguyen, Quoc Huy., Pham, Thanh Ky. L-Tetrahydropalmatine and sinomenine from Vietnamese Stephania sinica (Diels.) grown in Quang Binh Province. tap chi duoc hoc, 2008, vol. 48, no. 12, p. 21–23. .

Language:

English (en)
Plant part:

Roots and other underground parts used as staple food (as part-nature) (A0F5F)
Substance:

sinomenine (RF-00003579-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sinomenine in roots

Composition #3: MIN, ZD., LIN, G., XU, GX., MUNEKAZU, I., TANAKA, T., MIZUNO, M. ALKALOIDS OF STEPHANIA-SINICA. phytochemistry, 1985, vol. 24, no. 12, p. 3084–3085. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

Isoquinoline alkaloids (RF-00004391-PAR)
Additional substance description:

cepharanthine
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, NMR, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

cepharanthine in roots

Composition #4: MIN, ZD., LIN, G., XU, GX., MUNEKAZU, I., TANAKA, T., MIZUNO, M. ALKALOIDS OF STEPHANIA-SINICA. phytochemistry, 1985, vol. 24, no. 12, p. 3084–3085. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

runanine (RF-00003568-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, NMR, IR
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

runanine in roots

Endpoint study #1: Chan, TYK., Tam, HP., Lai, CK., Chan, AYW. A multidisciplinary approach to the toxicologic problems associated with the use of herbal medicines . therapeutic drug monitoring, 2005, vol. 27, no. 1, p. 53–57. DOI: 10.1097/00007691-200502000-00011. [DOI link]

Study relevance:

Human health
Substance:

tetrahydropalmatin (RF-00003602-PAR)
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Sex:

Male/Female
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Unit of exposure duration:

single (food/feed) (G203A)
Number of organisms dosed:

3
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

Digestive (TOX18A)
Target tissue:

Digestive (TT002A)
Effect description:

nausea, vomiting, abdominal pain, diarrhea,
Effect or parameter linked to the endpoint:

food consumption (CHD007BE)
Internal remarks:

nausea, vomiting, abdominal pain, diarrhea