Draft - work in progress
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- Securigera varia (L.) Lassen // Coronilla varia L.
Securigera varia (L.) Lassen // Coronilla varia L.
- Family:
- Fabaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 543
- Number of processed references:
- 9
Composition #1: Joo, Pilju K., McKee, G. W., MacDonald, H. A., Langille, R. A. Isolation and identification of phytotoxic substances from seeds of Coronilla varia L. proceedings of the association of official seed analysts, 1975, vol. 65, p. 38–51. .
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Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
distilled water leachate
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Substance:
scopoletin (RF-00004048-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
GC, UV
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
scopoletin in seed
Composition #2: Joo, Pilju K., McKee, G. W., MacDonald, H. A., Langille, R. A. Isolation and identification of phytotoxic substances from seeds of Coronilla varia L. proceedings of the association of official seed analysts, 1975, vol. 65, p. 38–51. .
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-
Plant part:
Seed (as part-nature) (A066P)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
distilled water leachate
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Substance:
p-coumaric acid (RF-00010717-PAR)
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Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
GC, UV
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
coumaric acids in seed
Composition #3: Joo, Pilju K., McKee, G. W., MacDonald, H. A., Langille, R. A. Isolation and identification of phytotoxic substances from seeds of Coronilla varia L. proceedings of the association of official seed analysts, 1975, vol. 65, p. 38–51. .
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-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
distilled water leachate
-
Substance:
umbelliferone (RF-00004096-PAR)
-
Analytical method code:
Chromatographic tests (F015A)
-
Analytical method - additional description:
GC, UV
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
umbelliferone in seed
Composition #4: Slavik, J., Zackova, P., Michlova, J., Opletal, L., Sovova, M. Phytotherapeutic aspects of the diseases of the circulatory system. Cardiotonic and cardiotoxic effects of hyrcanoside and deglucohyrcanoside isolated from Coronilla varia L. ceska a slovenska farmacie, 1994, vol. 43, no. 6), 29, p. 302. .
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-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
unspecified
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Substance:
deglucohyrcanoside (RF-00004256-PAR)
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Analytical method code:
Unspecified (F598A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
deglucohyrcanoside in seeds
Composition #5: Slavik, J., Zackova, P., Michlova, J., Opletal, L., Sovova, M. Phytotherapeutic aspects of the diseases of the circulatory system. Cardiotonic and cardiotoxic effects of hyrcanoside and deglucohyrcanoside isolated from Coronilla varia L. ceska a slovenska farmacie, 1994, vol. 43, no. 6), 29, p. 302. .
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-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
unspecified
-
Substance:
hyrcanoside (RF-00003436-PAR)
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Analytical method code:
Unspecified (F598A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
hyrcanoside in seeds
Composition #6: Brown, Ron H., Mueller-Harvey, Irene., Zeller, Wayne E., Reinhardt, Laurie., Stringano, Elisabetta., Gea, An., Drake, Christopher., Ropiak, Honorata M., Fryganas, Christos., Ramsay, Aina., . Facile Purification of Milligram to Gram Quantities of Condensed Tannins According to Mean Degree of Polymerization and Flavan-3-ol Subunit Composition. journal of agricultural and food chemistry, 2017, vol. 65, no. 36, p. 8072–8082. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
aceton and water
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Substance:
Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
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Analytical method code:
Chromatographic tests (F015A)
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Result unit:
Gram/100 gram (G013A)
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Result expression:
Reconstituted product (B007A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
23.2
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Internal remarks:
condensed tanins in aerial parts
Composition #7: Komissarenko, N.F. Cardenolides and coumarins of Coronilla varia, C. cretica, etc.. chemistry of natural compounds, 1969, vol. 5, no. 3, p. 121–123. DOI: 10.1007/BF00636001.
[
DOI link]
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Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
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Substance:
coumarins (RF-00004351-PAR)
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Additional substance description:
umbelliferone, scopoletin, and daphnoretin
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
umbelliferone, scopoletin, and daphnoretin in seeds
Composition #8: Komissarenko, N.F. Cardenolides and coumarins of Coronilla varia, C. cretica, etc.. chemistry of natural compounds, 1969, vol. 5, no. 3, p. 121–123. DOI: 10.1007/BF00636001.
[
DOI link]
-
-
Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
-
Substance:
hyrcanoside (RF-00003436-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
hyrcanoside in seeds
Composition #9: Hanganu, Daniela., Vlase, Laurian., Olah, Neli. Phytochemical Analysis of Isoflavons from some Fabaceae Species Extracts. notulae botanicae horti agrobotanici cluj-napoca, 2010, vol. 38, no. 1, p. 57–60. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol
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Substance:
genistein (RF-00000297-NTR)
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Analytical method code:
HPLC with standard detection methods (F019A)
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Analytical method - additional description:
HPLC-MS/MS
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Result unit:
Microgram/millilitre (G052A)
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Result expression:
Reconstituted product (B007A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
0.34
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Internal remarks:
genistein in aerial parts
Composition #10: Hanganu, Daniela., Vlase, Laurian., Olah, Neli. Phytochemical Analysis of Isoflavons from some Fabaceae Species Extracts. notulae botanicae horti agrobotanici cluj-napoca, 2010, vol. 38, no. 1, p. 57–60. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
ethanol
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Substance:
genistin (RF-00003829-PAR)
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Analytical method code:
HPLC with standard detection methods (F019A)
-
Analytical method - additional description:
HPLC-MS/MS
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Result unit:
Microgram/millilitre (G052A)
-
Result expression:
Reconstituted product (B007A)
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Result type:
Numerical Value (VAL)
-
Value (concentration, content):
1.1
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Internal remarks:
genistin in aerial parts
Composition #11: TERRILL, TH., ROWAN, AM., DOUGLAS, GB., BARRY, TN. DETERMINATION OF EXTRACTABLE AND BOUND CONDENSED TANNIN CONCENTRATIONS IN FORAGE PLANTS, PROTEIN-CONCENTRATE MEALS AND CEREAL-GRAINS . journal of the science of food and agriculture, 1992, vol. 58, no. 3, p. 321–329. DOI: 10.1002/jsfa.2740580306.
[
DOI link]
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
forage
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Substance:
Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
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Analytical method code:
UV/VIS spectroscopy (photometry) (F009A)
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Result unit:
Percent (G138A)
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Result expression:
Dry matter (B002A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
3
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Internal remarks:
condensed tannins in forage
Composition #12: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .
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Plant part:
Seed (as part-nature) (A066P)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
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Substance:
daphnoretin (RF-00004252-PAR)
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Analytical method - additional description:
TLC
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
daphnoretin seeds
Composition #13: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
scopoletin (RF-00004048-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Analytical method - additional description:
TLC, UV, Ms
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
scopoletin in live plant
Composition #14: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
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Substance:
daphnoretin (RF-00004252-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Analytical method - additional description:
TLC
-
Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
daphnoretin roots
Composition #15: Innocenti, G., Piovan, A., Caniato, R., Filippini, R., Cappelletti, EM. Within-plant distribution of coumarins in Coronilla and Securigera species . international journal of pharmacognosy, 1996, vol. 34, no. 2, p. 114–118. .
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-
Plant part:
Live plants (as part-nature) (A0BA0)
-
Extraction/Preparation method:
Solvent extraction (A0BZR)
-
Additional extraction description:
methanol
-
Substance:
umbelliferone (RF-00004096-PAR)
-
Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
-
Analytical method - additional description:
TLC, UV, MS
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Yes/No Qualitative:
Positive/Present (POS)
-
Result type:
Qualitative Value (Binary) (BIN)
-
Internal remarks:
umbelliferone in live plant
Endpoint study
#1: Campbell, Terry W. Crown Vetch (Coronilla varia) poisoning in a budgerigar (Melopsittacus undulatus) . journal of avian medicine and surgery, 2006, vol. 20, no. 2, p. 97–100. DOI: 10.1647/2005-009.1.
[
DOI link]
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Study relevance:
Animal (target species) health
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Substance:
3-nitropropionic acid (RF-00004442-PAR)
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Type of toxicological test:
case report (CHD060TT)
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Limit test:
Not applicable
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Tested organism:
Bird (as animal) (A057X)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Hour (G099A)
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Number of organisms dosed:
1
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Neurologic (TT004A)
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Effect description:
vomiting and neurologic symptoms (weakness, incoordination, tremors, depression)
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Effect or parameter linked to the endpoint:
neurology (CHD027BE)
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Internal remarks:
vomiting and neurologic symptoms (weakness, incoordination, tremors, depression) budgerigar (Melopsittacus undulatus) intoxicated
Endpoint study
#2: SHENK, JS., WANGSNESS, PJ., LEACH, RM., GUSTINE, DL., GOBBLE, JL., BARNES, RF. RELATIONSHIP BETWEEN B-NITROPROPIONIC ACID CONTENT OF CROWNVETCH AND TOXICITY IN NON-RUMINANT ANIMALS . journal of animal science, 1976, vol. 42, no. 3, p. 616–621. .
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Study relevance:
Animal (target species) health
-
Substance:
3-nitropropionic acid (RF-00004442-PAR)
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Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
short-term toxicity (CHD017TT)
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Tested organism:
Rodents (as animal) (A0CNS)
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Route of exposure:
ORAL: FEED (OECD2230PL)
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Unit of exposure duration:
Day (G134A)
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Number of organisms dosed:
5
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Control groups used:
no data
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Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Grams per day (G233A)
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Effect concentration:
1.5
-
Critical effect:
NEUROTOXICITY (TOX04A)
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Target tissue:
Neurologic (TT004A)
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Effect description:
mortality, reduced activity, incoordination
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
incoordination, nitropropionic acid intoxicated voles
Endpoint study
#3: SHENK, JS., WANGSNESS, PJ., LEACH, RM., GUSTINE, DL., GOBBLE, JL., BARNES, RF. RELATIONSHIP BETWEEN B-NITROPROPIONIC ACID CONTENT OF CROWNVETCH AND TOXICITY IN NON-RUMINANT ANIMALS . journal of animal science, 1976, vol. 42, no. 3, p. 616–621. .
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Study relevance:
Animal (target species) health
-
Substance:
3-nitropropionic acid (RF-00004442-PAR)
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Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
Tested organism:
Gallus gallus (chicken) (as animal) (A057Z)
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Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
10
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Control groups used:
no data
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Grams per day (G233A)
-
Effect concentration:
1.5
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
mortality, incoordination,stagerring
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Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
incoordination, nitropropionic acid intoxicated chickens
Endpoint study
#4: SHENK, JS., WANGSNESS, PJ., LEACH, RM., GUSTINE, DL., GOBBLE, JL., BARNES, RF. RELATIONSHIP BETWEEN B-NITROPROPIONIC ACID CONTENT OF CROWNVETCH AND TOXICITY IN NON-RUMINANT ANIMALS . journal of animal science, 1976, vol. 42, no. 3, p. 616–621. .
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Study relevance:
Animal (target species) health
-
Substance:
3-nitropropionic acid (RF-00004442-PAR)
-
Plant part:
Aerial part of plants (as part-nature) (A166F)
-
Additional plant/substance description:
15%
-
Type of toxicological test:
short-term toxicity (CHD017TT)
-
Tested organism:
Pig (as animal) (A057F)
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-
Route of exposure:
ORAL: FEED (OECD2230PL)
-
-
Unit of exposure duration:
Day (G134A)
-
Number of organisms dosed:
12
-
Control groups used:
no data
-
Endpoint measured:
Dose level (CHD014EP)
-
Concentration unit:
Grams per day (G233A)
-
Effect concentration:
2.9
-
Critical effect:
NEUROTOXICITY (TOX04A)
-
Target tissue:
Neurologic (TT004A)
-
Effect description:
mortality, reduced activity, incoordination, ataxia, weigth lose
-
Effect or parameter linked to the endpoint:
mortality (CHD010BE)
-
Internal remarks:
incoordination, nitropropionic acid intoxicated pigs