EFSA Compendium of Botanicals

Draft - work in progress

Sanicula europaea L.

Family:: Apiaceae
Approval state:: Approved
Number of articles retrieved:: 114
Number of processed references:: 4

Compositions

#1: saniculoside R-1 in leaves #2: Saniculasaponins in aerial parts #3: Alpha-calacorene in leaves #4: Saniculoside N - aerial part

Endpoint Studies

Genotoxicity

Composition #1: Schopke, T., Janka, M., Nimtz, M., Wray, V., Hiller, K. Saniculoside R-1: A new triterpenoid saponin from Sanicula europaea. planta medica, 1998, vol. 64, no. 1, p. 83–85. DOI: 10.1055/s-2006-957377. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

MeOH 80% + column chromatography
Substance:

saniculoside R-1 (RF-00004042-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Analytical method - additional description:

UV, IR, MS
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

saniculoside R-1 in leaves

Composition #2: Walthelm, U., Dittrich, K., Gelbrich, G., Schopke, T. Effects of saponins on the water solubility of different model compounds. planta medica, 2001, vol. 67, no. 1, p. 49–54. DOI: 10.1055/s-2001-10876. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

water
Substance:

pentacyclic triterpene saponins (RF-00004334-PAR)
Additional substance description:

Saniculasaponins
Analytical method code:

HPLC-DAD (F587A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saniculasaponins in aerial parts

Composition #3: Pavlovic, Milica., Kovacevic, Nada., Tzakou, Olga., Couladis, Maria. Essential oil composition of Sanicula europaea L.. flavour and fragrance journal, 2006, vol. 21, no. 4, p. 687–689. DOI: 10.1002/ffj.1672. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Essential oil (as part-nature) (A166Q)
Additional extraction description:

hydrodistillation
Substance:

Alpha-calacorene (RF-00011308-PAR)
Analytical method code:

GC-MS (F046A)
Result unit:

Percent (G138A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.6-1.5
Internal remarks:

Alpha-calacorene in leaves

Composition #4: Arda, N., Goren, N., Kuru, A., Pengsuparp, T., Pezzuto, JM., Qiu, SX., Cordell, GA. Saniculoside N from Sanicula europaea L.. journal of natural products, 1997, vol. 60, no. 11, p. 1170–1173. DOI: 10.1021/np9701790. [DOI link]

Language:

English (en)
Plant part:

Aerial part of plants (as part-nature) (A166F)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

50% EtOH
Substance:

saniculoside N (RF-00004041-PAR)
Analytical method code:

Nuclear Magnetic Resonance (NMR) (F061A)
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

Saniculoside N - aerial part