EFSA Compendium of Botanicals

Draft - work in progress

Salvia divinorum Epling & Játiva

Family:: Lamiaceae
Approval state:: Approved
Number of articles retrieved:: 555
Number of processed references:: 3

Compositions

#1: salvinorin A in leaves #2: salvinorin A in leaves

Endpoint Studies

#1: Persistent anxiety, time disorientation, Burning mouth, Anxiety, palpitations,

Genotoxicity

Composition #1: Shirota, Osamu., Nagamatsu, Kumi., Sekita, Setsuko. Simple preparative isolation of salvinorin a from the hallucinogenic sage, Salvia divinorum, by centrifugal partition chromatography . journal of liquid chromatography & related technologies, 2007, vol. 30, no. 5-8, p. 1105–1114. DOI: 10.1080/10826070601128477. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

n-hexane–dichloromethane–methanol–water
Substance:

salvinorin A (RF-00004475-PAR)
Analytical method code:

HPLC with standard detection methods (F019A)
Analytical method - additional description:

centrifugal partition chromatography,NMR
Result unit:

Percent (G138A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.25-0.3
Internal remarks:

salvinorin A in leaves

Composition #2: Lin, Po-Xiang., Li, Jih-Heng., Chen, Su-Hwei., Chang, Hsien-Chang., McKetin, Rebecca. Quantitative determination of salvinorin A, a natural hallucinogen with abuse liability, in Internet-available Salvia divinorum and endemic species of Salvia in Taiwan . journal of food and drug analysis, 2014, vol. 22, no. 3, p. 370–378. DOI: 10.1016/j.jfda.2014.01.017. [DOI link]

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol
Substance:

salvinorin A (RF-00004475-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Microgram/100 millilitre (G047A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

81.04-87.16
Internal remarks:

salvinorin A in leaves

Endpoint study #1: Vohra, Rais., Seefeld, Andrew., Cantrell, F. Lee., Clark, Richard F. SALVIA DIVINORUM: EXPOSURES REPORTED TO A STATEWIDE POISON CONTROL SYSTEM OVER 10 YEARS . journal of emergency medicine, 2011, vol. 40, no. 6, p. 643–650. DOI: 10.1016/j.jemermed.2009.05.019. [DOI link]

Study relevance:

Human health
Type of toxicological test:

case report (CHD060TT)
Tested organism:

Human (as organism) (A056J)
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Control groups used:

no
Endpoint measured:

Dose not reported (CHD066EP)
Critical effect:

NEUROTOXICITY (TOX04A)
Target tissue:

Neurologic (TT004A)
Effect description:

Altered mental state (Persistent anxiety, time disorientation), Burning mouth, Anxiety, palpitations
Effect or parameter linked to the endpoint:

neurology (CHD027BE)
Internal remarks:

Persistent anxiety, time disorientation, Burning mouth, Anxiety, palpitations,