EFSA
ecomole
vscht
  2. Rue (as plant) // Ruta graveolens L.

Rue (as plant) // Ruta graveolens L.

Family:
Rutaceae
Approval state:
Approved
Number of articles retrieved:
1542
Number of processed references:
11
Compositions
#1: Gamma fagarine in roots #2: Umbelliferone in nectaries and roots #3: alkaloids in leaves #4: psoralen in stem #5: bergapten in stem #6: psoralen in leaves #7: xanthotoxin in stem #8: bergapten in leaves #9: xanthotoxin in leaves #10: isopimpinellin in leaves #11: bergapten in leaves #12: xanthotoxin in leaves #13: psoralen in leaves #14: isopimpinelin in aerial parts and roots #15: arborinine in aerial parts and roots #16: dictamine in aerial parts and roots #17: kokusaginine in aerial parts and roots #18: chalepensin, graveolinine in aerial parts and roots #19: clausindin, rutamarin in aerial parts and roots #20: scopoletin in aerial parts and roots #21: safrole in aerial parts and roots #22: graveoline in aerial parts and roots #23: skimmianine in aerial parts and roots #24: Rutacridone and Rutacridone-epoxide in aerial parts and roots #25: psoralen in aerial parts and roots #26: Bergapten in aerial parts and roots #27: Xanthotoxin in aerial parts and roots #28: rutacridone in roots
Endpoint Studies
#1: Significant decrease in testicles volume, and spermatozoids number and motility in rats #2: reproduction toxicity after application 1-6 day post-coitum #3: developmental toxicity after application 6-15 day post-coitum #4: acute toxicity - mice #5: case report - abdominal pain, vomiting, liver enlargement, oligo-anuria, jaundice #6: case report - genital hemorrhage, abortion, anemia, neurologic depression
Genotoxicity
#1: chloroform extract induce breaks in DNA strand #2: Increased number of MK in chloroform extract
Composition #1: Novak, Istvan., Szendrei, Kalman., Buzas, Geza., Minker, Emil., Koltai, Matyas. Isolation of the active substance from rutae radix. I. acta pharmaceutica hungarica, 1967, vol. 37, no. 5, p. 225–9. .
Composition #2: Andon, T. M., Denisova, G. A. Localization of coumarin compound in secretory receptacles of Ruta graveolens. rastitel'nye resursy, 1974, vol. 10, no. 4, p. 528–40. .
Composition #3: de Carvalho, Alessandra Vargas., Luebeck, Irina., da Rocha, Mariana Balhego., Gueez, Camila Martins., Machado, Michel Mansur., Souza de Oliveira, Luis Flavio. Evaluation of the tickcide, genotoxic, and mutagenic effects of the Ruta graveolens L. (Rutaceae) . acta scientiarum biological sciences, 2015, vol. 37, no. 4, p. 491–497. DOI: 10.4025/actascibiolsci.v37i4.27576. [DOI link]
Composition #4: Manjula, B.L., Sushma Mani, K. RP-HPLC analysis of furanocoumarins-psoralen, bergapten and xanthotoxin in Ruta graveolens L. international journal of pharmacognosy and phytochemical research, 2016, vol. 8, no. 2, p. 235–238. .
Composition #5: Manjula, B.L., Sushma Mani, K. RP-HPLC analysis of furanocoumarins-psoralen, bergapten and xanthotoxin in Ruta graveolens L. international journal of pharmacognosy and phytochemical research, 2016, vol. 8, no. 2, p. 235–238. .
Composition #6: Manjula, B.L., Sushma Mani, K. RP-HPLC analysis of furanocoumarins-psoralen, bergapten and xanthotoxin in Ruta graveolens L. international journal of pharmacognosy and phytochemical research, 2016, vol. 8, no. 2, p. 235–238. .
Composition #7: Manjula, B.L., Sushma Mani, K. RP-HPLC analysis of furanocoumarins-psoralen, bergapten and xanthotoxin in Ruta graveolens L. international journal of pharmacognosy and phytochemical research, 2016, vol. 8, no. 2, p. 235–238. .
Composition #8: Manjula, B.L., Sushma Mani, K. RP-HPLC analysis of furanocoumarins-psoralen, bergapten and xanthotoxin in Ruta graveolens L. international journal of pharmacognosy and phytochemical research, 2016, vol. 8, no. 2, p. 235–238. .
Composition #9: Manjula, B.L., Sushma Mani, K. RP-HPLC analysis of furanocoumarins-psoralen, bergapten and xanthotoxin in Ruta graveolens L. international journal of pharmacognosy and phytochemical research, 2016, vol. 8, no. 2, p. 235–238. .
Composition #10: Milesi, S., Massot, B., Gontier, E., Bourgaud, F., Guckert, A. Ruta graveolens L.: a promising species for the production of furanocoumarins . plant science, 2001, vol. 161, no. 1, p. 189–199. DOI: 10.1016/S0168-9452(01)00413-7. [DOI link]
Composition #11: Milesi, S., Massot, B., Gontier, E., Bourgaud, F., Guckert, A. Ruta graveolens L.: a promising species for the production of furanocoumarins . plant science, 2001, vol. 161, no. 1, p. 189–199. DOI: 10.1016/S0168-9452(01)00413-7. [DOI link]
Composition #12: Milesi, S., Massot, B., Gontier, E., Bourgaud, F., Guckert, A. Ruta graveolens L.: a promising species for the production of furanocoumarins . plant science, 2001, vol. 161, no. 1, p. 189–199. DOI: 10.1016/S0168-9452(01)00413-7. [DOI link]
Composition #13: Milesi, S., Massot, B., Gontier, E., Bourgaud, F., Guckert, A. Ruta graveolens L.: a promising species for the production of furanocoumarins . plant science, 2001, vol. 161, no. 1, p. 189–199. DOI: 10.1016/S0168-9452(01)00413-7. [DOI link]
Composition #14: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #15: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #16: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #17: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #18: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #19: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #20: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #21: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #22: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #23: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #24: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #25: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #26: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #27: Wu, TS., Shi, LS., Wang, JJ., Iou, SC., Chang, HC., Chen, YP., Kuo, YH., Chang, YL., Teng, CM. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. journal of the chinese chemical society, 2003, vol. 50, no. 1, p. 171–178. .
Composition #28: SCHIMMER, O., KIEFER, J., PAULINI, H. INHIBITORY EFFECTS OF FUROCOUMARINS IN SALMONELLA-TYPHIMURIUM TA98 ON THE MUTAGENICITY OF DICTAMNINE AND RUTACRIDONE, PROMUTAGENS FROM RUTA-GRAVEOLENS L . mutagenesis, 1991, vol. 6, no. 6, p. 501–506. DOI: 10.1093/mutage/6.6.501. [DOI link]
Endpoint study #1: Hammiche, V., Azzouz, M. The Rues: ethnobotany, phytopharmacology and toxicity. phytotherapie (paris), 2013, vol. 11, no. 1, p. 22–30. DOI: 10.1007/s10298-013-0751-9. [DOI link]
Endpoint study #2: Al-Mahmoud, M.S., Elbetieha, A., Al-Muhur, R.A. Anticonceptive and antifertility activities of various Ruta graveolens extracts in female rats. acta pharmaceutica turcica, 2003, vol. 45, no. 3, p. 203–212. .
Endpoint study #3: Al-Mahmoud, M.S., Elbetieha, A., Al-Muhur, R.A. Anticonceptive and antifertility activities of various Ruta graveolens extracts in female rats. acta pharmaceutica turcica, 2003, vol. 45, no. 3, p. 203–212. .
Endpoint study #4: Logarto Parra, A., Silva Yhebra, R., Guerra Sardinas, I., Iglesias Buela, L. Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. . phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, vol. 8, no. 5, p. 395–400. .
Endpoint study #5: Ciganda, C., Laborde, A. Herbal infusions used for induced abortion. journal of toxicology-clinical toxicology, 2003, vol. 41, no. 3, p. 235–239. DOI: 10.1081/CLT-120021104. [DOI link]
Endpoint study #6: Ciganda, C., Laborde, A. Herbal infusions used for induced abortion. journal of toxicology-clinical toxicology, 2003, vol. 41, no. 3, p. 235–239. DOI: 10.1081/CLT-120021104. [DOI link]
Genotox #1: de Carvalho, Alessandra Vargas., Luebeck, Irina., da Rocha, Mariana Balhego., Gueez, Camila Martins., Machado, Michel Mansur., Souza de Oliveira, Luis Flavio. Evaluation of the tickcide, genotoxic, and mutagenic effects of the Ruta graveolens L. (Rutaceae) . acta scientiarum biological sciences, 2015, vol. 37, no. 4, p. 491–497. DOI: 10.4025/actascibiolsci.v37i4.27576. [DOI link]
Genotox #2: de Carvalho, Alessandra Vargas., Luebeck, Irina., da Rocha, Mariana Balhego., Gueez, Camila Martins., Machado, Michel Mansur., Souza de Oliveira, Luis Flavio. Evaluation of the tickcide, genotoxic, and mutagenic effects of the Ruta graveolens L. (Rutaceae) . acta scientiarum biological sciences, 2015, vol. 37, no. 4, p. 491–497. DOI: 10.4025/actascibiolsci.v37i4.27576. [DOI link]