EFSA Compendium of Botanicals

Draft - work in progress

Rumex acetosella L.

Family:: Polygonaceae
Approval state:: Approved
Number of articles retrieved:: 821
Number of processed references:: 3

Compositions

Endpoint Studies

#1: strong alpha-amylase inhibition activity

Genotoxicity

Composition #1: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

rhein (RF-00004027-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

rhein in roots, leaves and fruits

Composition #2: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Fruit unspecified (as part-nature) (A067D)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

anthracene derivatives (RF-00004342-PAR)
Additional substance description:

aloe-emodin, aloin, chrysophanol, emodin, physcion, rhein,sennoside A, sennoside B
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

12.93
Internal remarks:

anthracene derivates in fruits

Composition #3: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Leaves (as part-nature) (A0EKT)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

anthracene derivatives (RF-00004342-PAR)
Additional substance description:

aloe-emodin, aloin, chrysophanol, emodin, physcion, rhein,sennoside A, sennoside B
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.1
Internal remarks:

anthracene derivates in leaves

Composition #4: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

anthracene derivatives (RF-00004342-PAR)
Additional substance description:

aloe-emodin, aloin, chrysophanol, emodin, physcion, rhein,sennoside A, sennoside B
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

3.66
Internal remarks:

anthracene derivates in roots

Composition #5: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

sennoside A (RF-00004051-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sennoside A in roots, leaves and fruits

Composition #6: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

aloin A (RF-00003672-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

aloin in roots, leaves and fruits

Composition #7: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

Aloe-emodin (RF-00003670-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

aloe-emodin in roots, leaves and fruits

Composition #8: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

Emodin (RF-00003798-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

emodin in roots, leaves and fruits

Composition #9: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

physcion (RF-00003993-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

physcion in roots, leaves and fruits

Composition #10: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

sennoside B (RF-00004052-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

sennoside B in roots, leaves and fruits

Composition #11: Wegiera, Magdalena., Smolarz, Helena D., Wianowska, Dorota., Dawidowicz, Andrzej L. Anthracene derivatives in some species of Rumex L. genus. acta societatis botanicorum poloniae, 2007, vol. 76, no. 2, p. 103–108. .

Language:

English (en)
Plant part:

Live plants (as part-nature) (A0BA0)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 80%
Substance:

chrysophanol (RF-00003737-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

RP-HPLC
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

chrysophanol in roots, leaves and fruits

Composition #12: Seziene, Vaida., Balezentiene, Ligita., Maruska, Audrius. Identification and allelochemical activity of phenolic compounds in extracts from the dominant plant species established in clear-cuts of Scots pine stands . iforest-biogeosciences and forestry, 2017, vol. 10, p. 309–314. DOI: 10.3832/ifor1791-009. [DOI link]

Language:

English (en)
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 75%
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

0.31
Internal remarks:

p-coumaric acid in roots

Composition #13: Seziene, Vaida., Balezentiene, Ligita., Maruska, Audrius. Identification and allelochemical activity of phenolic compounds in extracts from the dominant plant species established in clear-cuts of Scots pine stands . iforest-biogeosciences and forestry, 2017, vol. 10, p. 309–314. DOI: 10.3832/ifor1791-009. [DOI link]

Language:

English (en)
Plant part:

Shoot (as part-nature) (A067T)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 75%
Substance:

p-coumaric acid (RF-00010717-PAR)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.03
Internal remarks:

p-coumaric acid in shoots

Composition #14: Seziene, Vaida., Balezentiene, Ligita., Maruska, Audrius. Identification and allelochemical activity of phenolic compounds in extracts from the dominant plant species established in clear-cuts of Scots pine stands . iforest-biogeosciences and forestry, 2017, vol. 10, p. 309–314. DOI: 10.3832/ifor1791-009. [DOI link]

Language:

English (en)
Plant part:

Shoot (as part-nature) (A067T)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

methanol 75%
Substance:

Coumarin (RF-00000370-TOX)
Analytical method code:

HPLC-UV (F021A)
Result unit:

Milligram/gram (G060A)
Result expression:

Dry matter (B002A)
Result type:

Numerical Value (VAL)
Value (concentration, content):

1.16
Internal remarks:

coumarin in shoots

Endpoint study #1: Ahmed, Dildar., Mughal, Qaria Mumtaz., Younas, Saba., Ikram, Muhammad. Study of phenolic content and urease and alpha-amylase inhibitory activities of methanolic extract of Rumex acetosella roots and its sub-fractions in different solvents . pakistan journal of pharmaceutical sciences, 2013, vol. 26, no. 3, p. 553–559. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

methanol 100%
Type of toxicological test:

in vitro (CHD061TT)
Limit test:

Not applicable
Control groups used:

yes
Endpoint measured:

Enzyme inhibition (CHD067EP)
Concentration unit:

Milligram/millilitre (G191A)
Effect concentration:

0.85
Critical effect:

Digestive (TOX18A)
Target tissue:

digestive: Pancreas (TT024A)
Effect description:

methanol extract and its sub-fractions possessed strong dose-dependent α-amylase inhibitory activity, IC50 value of 0.85 mg/mL
Effect or parameter linked to the endpoint:

enzyme inhibition (CHD032BE)
Internal remarks:

strong alpha-amylase inhibition activity