Draft - work in progress
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- Rugosa rose (as plant) // Rosa rugosa Thunb.
Rugosa rose (as plant) // Rosa rugosa Thunb.
- Family:
- Rosaceae
- Approval state:
- Approved
- Number of articles retrieved:
- 1187
- Number of processed references:
- 11
Composition #1: Shnaidman, L. O., Kushchinskaya, I. N. Identification of the flavone and catechol compounds in the fruits of Rosa cinnamomea and Rosa rugosa. meditsinskaya promyshlennost sssr, 1965, vol. 19, no. 2, p. 14–17. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
MeOH
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Substance:
Catechol Catechol (RF-00010857-PAR)
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Additional substance description:
catechol, l-epigallocatechol, l-gallocatechol, l-epicatechol, l-epigallocatechol gallate, and l-epicatechol gallate
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Analytical method code:
Standard Chromatographic tests (paper- thin layer- and column chromatography) (F016A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Catechol and derivatives in dried fruit
Composition #2: Wu, Chengshun., Wang, Yi., Zhao, Dexiu., Sun, Shouwei., Ma, Yaping., Chen, Jian. The main chemical components of the essential oil from Rosa rugosa Thunb. zhiwu xuebao, 1985, vol. 27, no. 5, p. 510–15. .
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Essential oil (as part-nature) (A166Q)
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Additional extraction description:
hydrodistillation
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Substance:
methyleugenol (RF-00003931-PAR)
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Analytical method code:
Unspecified (F598A)
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Result unit:
Percent (G138A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
6.88
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Internal remarks:
Methyleugenol in flowers
Composition #3: Borkowski, B., Milkowska, K. Tannins, tannoids and related compounds. III. Ellagitannin. herba polonica, 1996, vol. 42, no. 2, p. 118–126. .
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Plant part:
Flower (as part-nature) (A067B)
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Substance:
Ellagitannins (hydrolysable tannins) Ellagitannins (hydrolysable tannins) (RF-00004379-PAR)
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Additional substance description:
monomeric ellagitannins
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Analytical method code:
Unspecified (F598A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
monomeric ellagitannins in petals
Composition #4: Cendrowski, Andrzej., Scibisz, Iwona., Mitek, Marta. THE CONTENT OF HYDROXYMETHYLFURFURAL IN CONFITURES FROM PETALS OF ROSA RUGOSA . bromatologia i chemia toksykologiczna, 2016, vol. 49, no. 3, p. 238–242. .
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water - cooking
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Substance:
Hydroxymethylfurfural (RF-00000379-ORG)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Milligram/100 gram (G057A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
3.6
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Internal remarks:
HYDROXYMETHYLFURFURAL in petals
Composition #5: Hallmann, E., Orpel, E., Rembiałkowska, E. The content of biologically active compounds in some fruits from natural state Zawartosc zwiazków biologicznie czynnych w róznych owocach ze stanu naturalnego . vegetable crops research bulletin, 2011, vol. 75, no. 1, p. 81–90. DOI: 10.2478/v10032-011-0020-8.
[
DOI link]
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Substance:
gallic acid (RF-00003821-PAR)
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Additional substance description:
methanol with ascorbic acid
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Milligram/100 gram (G057A)
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Result expression:
Whole weight (B001A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
92.4
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Internal remarks:
gallic acid in fruits
Composition #6: Li, L.-M., Lou, J., Liu, G.-Y., Wang, H., Yang, J.-X., Wang, Y.-D., Dong, W., Zhou, K., Hu, Q.-F. Isoflavones from flower buds of Rosa rugosa and their cytotoxicity. chinese traditional and herbal drugs, 2015, vol. 46, no. 10, p. 1420–1422. DOI: 10.7501/j.issn.0253-2670.2015.10.002.
[
DOI link]
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Plant part:
Bud (as part-nature) (A066Z)
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Substance:
isoflavones (RF-00004359-PAR)
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Additional substance description:
6,8-dihydroxy-4',7-dimethoxyisoflavone
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Isoflavones in buds
Composition #7: Li, L.-M., Lou, J., Liu, G.-Y., Wang, H., Yang, J.-X., Wang, Y.-D., Dong, W., Zhou, K., Hu, Q.-F. Isoflavones from flower buds of Rosa rugosa and their cytotoxicity. chinese traditional and herbal drugs, 2015, vol. 46, no. 10, p. 1420–1422. DOI: 10.7501/j.issn.0253-2670.2015.10.002.
[
DOI link]
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Plant part:
Bud (as part-nature) (A066Z)
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Substance:
Prunetin (RF-00011016-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Prunetin in buds
Composition #8: Li, L.-M., Lou, J., Liu, G.-Y., Wang, H., Yang, J.-X., Wang, Y.-D., Dong, W., Zhou, K., Hu, Q.-F. Isoflavones from flower buds of Rosa rugosa and their cytotoxicity. chinese traditional and herbal drugs, 2015, vol. 46, no. 10, p. 1420–1422. DOI: 10.7501/j.issn.0253-2670.2015.10.002.
[
DOI link]
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Plant part:
Bud (as part-nature) (A066Z)
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Substance:
Pratensein (RF-00011015-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Pratensein in buds
Composition #9: An, Hyo-Jin., Kim, In-Tae., Park, Hee-Juhn., Kim, Hyung-Min., Choi, Jung-Hye., Lee, Kyung-Tae. Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-alpha expression through inactivation of the nuclear factor-kappa b pathway in RAW 264.7 macrophages . international immunopharmacology, 2011, vol. 11, no. 4, p. 504–510. DOI: 10.1016/j.intimp.2011.01.002.
[
DOI link]
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Plant part:
Roots and other underground parts (as part-nature) (A067M)
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Additional extraction description:
unspecified
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Substance:
Triterpene saponins Triterpene saponins (RF-00004338-PAR)
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Additional substance description:
tormentic acid, Kaji-ichigoside F1, rosamultin, euscaphic acid
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Analytical method code:
LC-MS (F026A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
tormentic acid, kaji-ichigoside F1, rosamultin, euscaphic acid in roots
Composition #10: Teleszko, Miroslawa., Wojdylo, Aneta., Oszmianski, Jan. CONTENT OF ELLAGIC ACID AND POLYMERIZED PROANTHOCYANIDINS IN PSEUDO FRUITS OF SELECTED ROSE SPECIES . zywnosc-nauka technologia jakosc, 2012, vol. 19, no. 5, p. 37–46. .
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Plant part:
Fruit unspecified (as part-nature) (A067D)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
70% glycerol + TFA
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Substance:
Proanthocyanidins (condensed tannins) Proanthocyanidins (condensed tannins) (RF-00004370-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Result unit:
Microgram/gram (G049A)
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Result expression:
Dry matter (B002A)
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Result type:
Numerical Value (VAL)
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Value (concentration, content):
25620.26
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Internal remarks:
Proanthocyanidins in fruit
Composition #11: Gu, Dongyu., Yang, Yi., Bakri, Mahinur., Chen, Qibin., Xin, Xuelei., Aisa, Haji Akber. A LC/QTOF-MS/MS Application to Investigate Chemical Compositions in a Fraction with Protein Tyrosine Phosphatase 1B Inhibitory Activity from Rosa Rugosa Flowers . phytochemical analysis, 2013, vol. 24, no. 6, p. 661–670. DOI: 10.1002/pca.2451.
[
DOI link]
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
50% ethanol
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Substance:
Gallotannins (RF-00013316-PAR)
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Analytical method code:
High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Gallotannins in flowers
Composition #12: Li, D. Q., Zhao, J., Xie, J., Li, S. P. A novel sample preparation and on-line HPLC-DAD-MS/MS-BCD analysis for rapid screening and characterization of specific enzyme inhibitors in herbal extracts: Case study of alpha-glucosidase . journal of pharmaceutical and biomedical analysis, 2014, vol. 88, p. 130–135. DOI: 10.1016/j.jpba.2013.08.029.
[
DOI link]
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Plant part:
Flower (as part-nature) (A067B)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
water and methanol
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Substance:
Digalloylglucose (RF-00011365-PAR)
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Analytical method code:
UV/VIS spectroscopy (photometry) (F009A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
Digalloylglucose in flowers
Endpoint study
#1: Feng, Shengbao., Song, Lixia., Liu, Yuancai., Lai, Fuli., Zuo, Gang., He, Guangyuan., Chen, Mingjie., Huang, Dejian. Hypoglycemic Activities of Commonly-Used Traditional Chinese Herbs. american journal of chinese medicine, 2013, vol. 41, no. 4, p. 849–864. DOI: 10.1142/S0192415X13500572.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Flower (as part-nature) (A067B)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
acetone/ethanol/water
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Type of toxicological test:
in vitro (CHD061TT)
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Endpoint measured:
Enzyme inhibition (CHD067EP)
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Concentration unit:
Microgram/millilitre (G052A)
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Effect concentration:
16.9
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Critical effect:
Digestive (TOX18A)
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Target tissue:
digestive: Pancreas (TT024A)
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Effect description:
inhibition of alpha amylase activity
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
inhibition of alpha amylase activity
Endpoint study
#2: Feng, Shengbao., Song, Lixia., Liu, Yuancai., Lai, Fuli., Zuo, Gang., He, Guangyuan., Chen, Mingjie., Huang, Dejian. Hypoglycemic Activities of Commonly-Used Traditional Chinese Herbs. american journal of chinese medicine, 2013, vol. 41, no. 4, p. 849–864. DOI: 10.1142/S0192415X13500572.
[
DOI link]
-
Study relevance:
Human health
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Plant part:
Flower (as part-nature) (A067B)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
acetone/ethanol/water
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Type of toxicological test:
in vitro (CHD061TT)
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Endpoint measured:
Enzyme inhibition (CHD067EP)
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Concentration unit:
Microgram/millilitre (G052A)
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Effect concentration:
50.8
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Critical effect:
Digestive (TOX18A)
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Target tissue:
digestive: Pancreas (TT024A)
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Effect description:
inhibition of alpha glucosidase activity
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
inhibition of alpha glucosidase activity
Endpoint study
#3: Li, D. Q., Zhao, J., Xie, J., Li, S. P. A novel sample preparation and on-line HPLC-DAD-MS/MS-BCD analysis for rapid screening and characterization of specific enzyme inhibitors in herbal extracts: Case study of alpha-glucosidase . journal of pharmaceutical and biomedical analysis, 2014, vol. 88, p. 130–135. DOI: 10.1016/j.jpba.2013.08.029.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Flower (as part-nature) (A067B)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
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Additional plant/substance description:
methanol
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Type of toxicological test:
in vitro (CHD061TT)
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Limit test:
Not applicable
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Control groups used:
yes, concurrent vehicle
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Endpoint measured:
Enzyme inhibition (CHD067EP)
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Concentration unit:
Microgram/millilitre (G052A)
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Effect concentration:
9.3
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
inhibition of alpha glucosidase activity
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
methanol extract - inhibition of alpha glucosidase activity
Endpoint study
#4: Li, D. Q., Zhao, J., Xie, J., Li, S. P. A novel sample preparation and on-line HPLC-DAD-MS/MS-BCD analysis for rapid screening and characterization of specific enzyme inhibitors in herbal extracts: Case study of alpha-glucosidase . journal of pharmaceutical and biomedical analysis, 2014, vol. 88, p. 130–135. DOI: 10.1016/j.jpba.2013.08.029.
[
DOI link]
-
Study relevance:
Human health
-
Plant part:
Flower (as part-nature) (A067B)
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Preparation/Extraction method:
Solvent extraction (A0BZR)
-
Additional plant/substance description:
water
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Type of toxicological test:
in vitro (CHD061TT)
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Limit test:
Not applicable
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Control groups used:
yes, concurrent vehicle
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Endpoint measured:
Enzyme inhibition (CHD067EP)
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Concentration unit:
Microgram/millilitre (G052A)
-
Effect concentration:
14.3
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
inhibition of alpha glucosidase activity
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Effect or parameter linked to the endpoint:
enzyme inhibition (CHD032BE)
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Internal remarks:
water extract - inhibition of alpha glucosidase activity