Draft - work in progress
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- Roemeria hybrida (L.) DC.
Roemeria hybrida (L.) DC.
- Family:
- Papaveraceae
- Approval state:
- Approved
- Number of articles retrieved:
- 33
- Number of processed references:
- 7
Compositions
#1: roehybridine, roemeridine
#2: misrametine, misrhybridine
#3: (-)-roehybridine alpha-N-oxide and (-)-roehybramine beta-N-oxide in aerial parts
#4: roehybridine beta-N-oxide in aerial parts
#5: aporphine alkaloids: (-)-roemerialinone, (-)-isoorientalinone, (-)-isoroemerialinone, (-)-ll,12-dihydroorientalinone, (+)-8,9-dihydroisoroemerialinone and (-)-e-roemehybrine, mecambrine, orientaline
#6: proaporphine-tryptamine alkaloids
#7: roecarboline, norroecarboline, roeharmine, 1,2,3,4-tetrahydroroeharmine
Composition #1: El-Masry, Sawsan., Amer, Masouda., Ghazy, Nabila M., El-Lakany, Abdalla M. Alkaloids from Roemeria hybrida L. growing in Egypt. alexandria journal of pharmaceutical sciences, 1990, vol. 4, no. 1, p. 90–3. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol 95%
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Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
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Additional substance description:
roehybridine, roemeridine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
TLC,
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
roehybridine, roemeridine
Composition #2: El-Masry, Sawsan., Amer, Masouda., Ghazy, Nabila M., El-Lakany, Abdalla M. Alkaloids from Roemeria hybrida L. growing in Egypt. alexandria journal of pharmaceutical sciences, 1990, vol. 4, no. 1, p. 90–3. .
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol 95%
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
misrametine, misrhybridine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
TLC,
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
misrametine, misrhybridine
Composition #3: Gunes, HS., Gozler, B. Two novel proaporphine-tryptamine dimers from Roemeria hybrida. fitoterapia, 2001, vol. 72, no. 8, p. 875–886. DOI: 10.1016/S0367-326X(01)00329-X.
[
DOI link]
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
(-)-roehybridine alpha-N-oxide, (-)-roehybramine beta-N-oxide
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
(-)-roehybridine alpha-N-oxide and (-)-roehybramine beta-N-oxide in aerial parts
Composition #4: Ebrahimi, Samad Nejad., Bagheri-Zomorrodi, Zahra., Shakeri, Abolfazl., Iranshahy, Milad., Masullo, Milena., Piacente, Sonia., Iranshahi, Mehrdad. The Absolute Configuration and Cytotoxic Properties of Roehybridine beta-N-oxide . natural product communications, 2016, vol. 11, no. 12, p. 1813–1816. .
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Plant part:
Aerial part of plants (as part-nature) (A166F)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
methanol
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Substance:
Isoquinoline alkaloids (RF-00004391-PAR)
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Additional substance description:
roehybridine beta-N-oxide
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
roehybridine beta-N-oxide in aerial parts
Composition #5: GOZLER, B., GOZLER, T., METE, IE., FREYER, AJ., GUINAUDEAU, H., SHAMMA, M. NEW PROAPORPHINE ALKALOIDS FROM ROEMERIA-HYBRIDA. tetrahedron, 1987, vol. 43, no. 8, p. 1765–1770. DOI: 10.1016/S0040-4020(01)81486-1.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol extract fractionation
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Substance:
Aporphine alkaloids (RF-00010806-PAR)
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Additional substance description:
(-)-roemerialinone, (-)-isoorientalinone, (-)-isoroemerialinone, (-)-ll,12-dihydroorientalinone, (+)-8,9-dihydroisoroemerialinone and (-)-e-roemehybrine, mecambrine, orientaline
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Analytical method - additional description:
NMR, TLC
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
aporphine alkaloids: (-)-roemerialinone, (-)-isoorientalinone, (-)-isoroemerialinone, (-)-ll,12-dihydroorientalinone, (+)-8,9-dihydroisoroemerialinone and (-)-e-roemehybrine, mecambrine, orientaline
Composition #6: GOZLER, B., FREYER, AJ., SHAMMA, M. THE 10 PROAPORPHINE-TRYPTAMINE DIMERS. journal of natural products, 1990, vol. 53, no. 3, p. 675–685. DOI: 10.1021/np50069a022.
[
DOI link]
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Plant part:
Live plants (as part-nature) (A0BA0)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol extract fractionation
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Substance:
Aporphine alkaloids (RF-00010806-PAR)
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Additional substance description:
(-)-roehybridine, (-)-norroehybridine, (-)-0-methylroehybridine, (-broehybridine p-N-oxide, (-)- roehybramine, (+)- roehymine, (+)-roebramine , (-)- roemeridine, (-)-0-methylroemeridine, and (-)-roemebramine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
proaporphine-tryptamine alkaloids
Composition #7: GOZLER, B., SHAMMA, M. 4 BETA-CARBOLINE ALKALOIDS FROM ROEMERIA-HYBRIDA. journal of natural products, 1990, vol. 53, no. 3, p. 740–743. DOI: 10.1021/np50069a038.
[
DOI link]
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Plant part:
Unspecified (A07XD)
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Extraction/Preparation method:
Solvent extraction (A0BZR)
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Additional extraction description:
ethanol
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Substance:
Alkaloids (RF-00004360-PAR)
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Additional substance description:
roecarboline, norroecarboline, roeharmine, 1,2,3,4-tetrahydroroeharmine
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Analytical method code:
Nuclear Magnetic Resonance (NMR) (F061A)
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Yes/No Qualitative:
Positive/Present (POS)
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Result type:
Qualitative Value (Binary) (BIN)
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Internal remarks:
roecarboline, norroecarboline, roeharmine, 1,2,3,4-tetrahydroroeharmine
Endpoint study
#1: Al-Qura'n, S. Ethnobotanical survey of folk toxic plants in southern part of Jordan. toxicon, 2005, vol. 46, no. 2, p. 119–129. DOI: 10.1016/j.toxicon.2005.04.010.
[
DOI link]
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Study relevance:
Human health
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Plant part:
Live plants (as part-nature) (A0BA0)
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Type of toxicological test:
case report (CHD060TT)
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Limit test:
Not applicable
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Tested organism:
Human (as organism) (A056J)
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Route of exposure:
ORAL: UNSPECIFIED (OECD2234PL)
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Number of organisms dosed:
8
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Endpoint measured:
Dose not reported (CHD066EP)
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Critical effect:
Digestive (TOX18A)
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Target tissue:
Digestive (TT002A)
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Effect description:
spasmodic, diarrhoeal
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Effect or parameter linked to the endpoint:
not reported (CHD030BE)
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Internal remarks:
digestive toxicity