EFSA Compendium of Botanicals

Draft - work in progress

Rhynchosia volubilis Lour.

Family:: Fabaceae
Approval state:: Approved
Number of articles retrieved:: 143
Number of processed references:: 3

Compositions

#1: glycitin in seeds #2: genistin and 6-O-acetyl genistin in seeds #3: daidzin in seeds

Endpoint Studies

#1: water extract has anti-fertility effect on male mice #2: anti-fertility effects on male mice

Genotoxicity

Composition #1: Jeon, Je-Seung., Kang, Suk Woo., Um, Byung-Hun., Kim, Chul Young. Preparative Isolation of Antioxidant Flavonoids from Small Black Soybeans by Centrifugal Partition Chromatography and Sequential Solid-Phase Extraction . separation science and technology, 2014, vol. 49, no. 17, p. 2756–2764. DOI: 10.1080/01496395.2014.937004. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 70%
Substance:

glycitin (RF-00003847-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ABTS+
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

glycitin in seeds

Composition #2: Jeon, Je-Seung., Kang, Suk Woo., Um, Byung-Hun., Kim, Chul Young. Preparative Isolation of Antioxidant Flavonoids from Small Black Soybeans by Centrifugal Partition Chromatography and Sequential Solid-Phase Extraction . separation science and technology, 2014, vol. 49, no. 17, p. 2756–2764. DOI: 10.1080/01496395.2014.937004. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 70%
Substance:

genistin (RF-00003829-PAR)
Additional substance description:

genistin and 6-O-acetyl genistin
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ABTS+
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

genistin and 6-O-acetyl genistin in seeds

Composition #3: Jeon, Je-Seung., Kang, Suk Woo., Um, Byung-Hun., Kim, Chul Young. Preparative Isolation of Antioxidant Flavonoids from Small Black Soybeans by Centrifugal Partition Chromatography and Sequential Solid-Phase Extraction . separation science and technology, 2014, vol. 49, no. 17, p. 2756–2764. DOI: 10.1080/01496395.2014.937004. [DOI link]

Language:

English (en)
Plant part:

Seed (as part-nature) (A066P)
Extraction/Preparation method:

Solvent extraction (A0BZR)
Additional extraction description:

Ethanol 70%
Substance:

daidzin (RF-00003763-PAR)
Analytical method code:

High Performance Liquid Chromatography (HPLC)/Liquid Chromatography (LC) (F018A)
Analytical method - additional description:

HPLC-ABTS+
Yes/No Qualitative:

Positive/Present (POS)
Result type:

Qualitative Value (Binary) (BIN)
Internal remarks:

daidzin in seeds

Endpoint study #1: Wang, Jian-gang., Zhang, Xiu-li., Xiong, Cheng-liang., Wang, Shu-ying., Wang, Juan-rui., Yin, Wei-ping. Anti-fertility effect of aqueous extract from roots of Rhynchosia volubilis Lour on male mice and chemical composition analysis. zhonghua shiyong zhongxiyi zazhi, 2007, vol. 20, no. 1, p. 75–77. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water extract
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

11.0
Unit of exposure duration:

Week (G205A)
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Milligrams per kilogram body weight per day (G211A)
Effect concentration:

25-400
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Urogenital (TT006A)
Effect description:

anti-fertility effect on male mice
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

water extract has anti-fertility effect on male mice

Endpoint study #2: Wang, Jian-Gang., Xiong, Cheng-Liang., Wang, Shu-Ying., Wu, Yin-Ping., Fu, Yin-Feng., Zhang, Zhao-Hui. Comparison of the anti-fertility effects of four extracts from the roots of Rhynchosia volubilis Lour . . zhonghua nan ke xue = national journal of andrology, 2007, vol. 13, no. 10, p. 871–5. .

Study relevance:

Human health
Plant part:

Roots and other underground parts (as part-nature) (A067M)
Preparation/Extraction method:

Solvent extraction (A0BZR)
Additional plant/substance description:

water extract
Type of toxicological test:

reproduction toxicity (CHD009TT)
Tested organism:

House mouse (as animal) (A0CNT)
Sex:

Male
Route of exposure:

ORAL: UNSPECIFIED (OECD2234PL)
Exposure duration:

11.0
Unit of exposure duration:

Week (G205A)
Endpoint measured:

Dose level (CHD014EP)
Concentration unit:

Percent (G138A)
Effect concentration:

1
Critical effect:

REPRODUCTIVE (TOX05A)
Target tissue:

Urogenital (TT006A)
Effect description:

numbers of the secondary spermatocytes and spermatids were decreased , and the seminiferous tubules were disarranged, while the numbers and shapes of and spermatids were decreased, the seminiferous tubules were disarranged
Effect or parameter linked to the endpoint:

reproduction (CHD014BE)
Internal remarks:

anti-fertility effects on male mice