EFSA
ecomole
vscht
  2. Rauvolfia vomitoria Afzel.

Rauvolfia vomitoria Afzel.

Family:
Rubiaceae
Approval state:
Approved
Number of articles retrieved:
156
Number of processed references:
12
Compositions
#1: phytic acid in seeds #2: oxalates in seeds #3: harman in roots #4: reserpine in roots #5: indole alkaloids (isosandwicine, methyl reserpate, ajmaline, sandwicine, isorauhimbine, perakine, mitoridine, tetraphyllicine, mauiensine, 12-hydroxymauiensine) in roots #6: yohimbine in roots #7: tetrahydroalstonine in roots #8: alpha-yohimbine in roots #9: Alkaloids in roots #10: Reserpine in roots #11: ajmaline, methylsarpagine, demethoxyreserpiline, sandwicolidine, ajmalinol in roots #12: ajmalicine in roots #13: yohimbine in leaves #14: reserpiline in leaves #15: darcyriberine in leaves #16: yohimbine in roots #17: Indole alkaloids (3-epi-rescinnamine, 3,4-dimethoxybenzoyl-reserpic acid methyl ester) in roots #18: ajmaline in roots #19: serpentine in roots #20: reserpine in roots #21: yohimbine in roots #22: ajmalicine in roots #23: ajmaline in leaves #24: yohimbine in leaves #25: ajmalicine in leaves #26: serpentine in leaves #27: reserpine in leaves #28: rauvomine A, rauvomine B, peraksine, alstoyunine A in aerial parts #29: ajmaline in root bark #30: rescinnamine in root bark #31: reserpine in root bark
Endpoint Studies
#1: alteration or degeneration of the histological architecture of the ovary #2: Adverse effects on the biochemical and clinical indices of liver and kidney functions. #3: increased HDL-C and triglyceride, increased HDL-C, changes in activities ALP, ACP, AST, ALT #4: Traumatic neuronal and astroglia changes in the olfactory bulb
Genotoxicity
Composition #1: Balogun, Adebisi M., Fetuga, Babatunde L. Tannin, phytin and oxalate contents of some wild underutilized crop-seeds in Nigeria. food chemistry, 1988, vol. 30, no. 1, p. 37–43. .
Composition #2: Balogun, Adebisi M., Fetuga, Babatunde L. Tannin, phytin and oxalate contents of some wild underutilized crop-seeds in Nigeria. food chemistry, 1988, vol. 30, no. 1, p. 37–43. .
Composition #3: Li, Lin., He, Hong-ping., Zhou, Hua., Hao, Xiao-jiang. Indole alkaloids from Rauwolfia vomitoria. tianran chanwu yanjiu yu kaifa, 2007, vol. 19, no. 2, p. 235–239. .
Composition #4: Li, Lin., He, Hong-ping., Zhou, Hua., Hao, Xiao-jiang. Indole alkaloids from Rauwolfia vomitoria. tianran chanwu yanjiu yu kaifa, 2007, vol. 19, no. 2, p. 235–239. .
Composition #5: Li, Lin., He, Hong-ping., Zhou, Hua., Hao, Xiao-jiang. Indole alkaloids from Rauwolfia vomitoria. tianran chanwu yanjiu yu kaifa, 2007, vol. 19, no. 2, p. 235–239. .
Composition #6: Li, Lin., He, Hong-ping., Zhou, Hua., Hao, Xiao-jiang. Indole alkaloids from Rauwolfia vomitoria. tianran chanwu yanjiu yu kaifa, 2007, vol. 19, no. 2, p. 235–239. .
Composition #7: Li, Lin., He, Hong-ping., Zhou, Hua., Hao, Xiao-jiang. Indole alkaloids from Rauwolfia vomitoria. tianran chanwu yanjiu yu kaifa, 2007, vol. 19, no. 2, p. 235–239. .
Composition #8: Li, Lin., He, Hong-ping., Zhou, Hua., Hao, Xiao-jiang. Indole alkaloids from Rauwolfia vomitoria. tianran chanwu yanjiu yu kaifa, 2007, vol. 19, no. 2, p. 235–239. .
Composition #9: Bindu, S., Rameshkumar, K. B., Kumar, Brijesh., Singh, Awantika., Anilkumar, C. Distribution of reserpine in Rauvolfia species from India - HPTLC and LC-MS studies. industrial crops and products, 2014, vol. 62, p. 430–436. .
Composition #10: Bindu, S., Rameshkumar, K. B., Kumar, Brijesh., Singh, Awantika., Anilkumar, C. Distribution of reserpine in Rauvolfia species from India - HPTLC and LC-MS studies. industrial crops and products, 2014, vol. 62, p. 430–436. .
Composition #11: Kumar, Sunil., Bajpai, Vikas., Singh, Awantika., Bindu, S., Srivastava, Mukesh., Rameshkumar, K. B., Kumar, Brijesh. Rapid fingerprinting of Rauwolfia species using direct analysis in real time mass spectrometry combined with principal component analysis for their discrimination. analytical methods, 2015, vol. 7, no. 14, p. 6021–6026. .
Composition #12: Kumar, Sunil., Bajpai, Vikas., Singh, Awantika., Bindu, S., Srivastava, Mukesh., Rameshkumar, K. B., Kumar, Brijesh. Rapid fingerprinting of Rauwolfia species using direct analysis in real time mass spectrometry combined with principal component analysis for their discrimination. analytical methods, 2015, vol. 7, no. 14, p. 6021–6026. .
Composition #13: Kumar, Sunil., Bajpai, Vikas., Singh, Awantika., Bindu, S., Srivastava, Mukesh., Rameshkumar, K. B., Kumar, Brijesh. Rapid fingerprinting of Rauwolfia species using direct analysis in real time mass spectrometry combined with principal component analysis for their discrimination. analytical methods, 2015, vol. 7, no. 14, p. 6021–6026. .
Composition #14: Kumar, Sunil., Bajpai, Vikas., Singh, Awantika., Bindu, S., Srivastava, Mukesh., Rameshkumar, K. B., Kumar, Brijesh. Rapid fingerprinting of Rauwolfia species using direct analysis in real time mass spectrometry combined with principal component analysis for their discrimination. analytical methods, 2015, vol. 7, no. 14, p. 6021–6026. .
Composition #15: Kumar, Sunil., Bajpai, Vikas., Singh, Awantika., Bindu, S., Srivastava, Mukesh., Rameshkumar, K. B., Kumar, Brijesh. Rapid fingerprinting of Rauwolfia species using direct analysis in real time mass spectrometry combined with principal component analysis for their discrimination. analytical methods, 2015, vol. 7, no. 14, p. 6021–6026. .
Composition #16: Kumar, Sunil., Bajpai, Vikas., Singh, Awantika., Bindu, S., Srivastava, Mukesh., Rameshkumar, K. B., Kumar, Brijesh. Rapid fingerprinting of Rauwolfia species using direct analysis in real time mass spectrometry combined with principal component analysis for their discrimination. analytical methods, 2015, vol. 7, no. 14, p. 6021–6026. .
Composition #17: Lovati, M., Peterlongo, F., Ruffilli, T., Zini, G. F. Two new indole alkaloids from Rauwolfia vomitoria. fitoterapia, 1996, vol. 67, no. 5, p. 422–426. .
Composition #18: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #19: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #20: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #21: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #22: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #23: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #24: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #25: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #26: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #27: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #28: Zeng, Jun., Zhang, Dong-Bo., Zhou, Pan-Pan., Zhang, Qi-Li., Zhao, Lei., Chen, Jian-Jun., Gao, Kun. Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria . organic letters, 2017, vol. 19, no. 15, p. 3998–4001. DOI: 10.1021/acs.orglett.7b01723. [DOI link]
Composition #29: DUEZ, P., CHAMART, S., VANHAELEN, M., VANHAELENFASTRE, R., HANOCQ, M., MOLLE, L. COMPARISON BETWEEN HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY-DENSITOMETRY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF AJMALINE, RESERPINE AND RESCINNAMINE IN RAUWOLFIA-VOMITORIA ROOT BARK . journal of chromatography, 1986, vol. 356, no. 2, p. 334–340. DOI: 10.1016/S0021-9673(00)91495-X. [DOI link]
Composition #30: DUEZ, P., CHAMART, S., VANHAELEN, M., VANHAELENFASTRE, R., HANOCQ, M., MOLLE, L. COMPARISON BETWEEN HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY-DENSITOMETRY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF AJMALINE, RESERPINE AND RESCINNAMINE IN RAUWOLFIA-VOMITORIA ROOT BARK . journal of chromatography, 1986, vol. 356, no. 2, p. 334–340. DOI: 10.1016/S0021-9673(00)91495-X. [DOI link]
Composition #31: DUEZ, P., CHAMART, S., VANHAELEN, M., VANHAELENFASTRE, R., HANOCQ, M., MOLLE, L. COMPARISON BETWEEN HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY-DENSITOMETRY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY FOR THE DETERMINATION OF AJMALINE, RESERPINE AND RESCINNAMINE IN RAUWOLFIA-VOMITORIA ROOT BARK . journal of chromatography, 1986, vol. 356, no. 2, p. 334–340. DOI: 10.1016/S0021-9673(00)91495-X. [DOI link]
Endpoint study #1: Aquiasia, N. A., Oyebadejo, S. A., Bassey, I. E., Ufot, A. L., Akpan, F. I. Effect of the ethanolic root extract of Rauwolfia vomitaria on the histology of the ovaries of female albino wistar rats. cibtech journal of pharmaceutical sciences, 2014, vol. 3, no. 3, p. 1–9. .
Endpoint study #2: Eteng, M.U., Ibekwe, H.A., Abolaji, A.O., Okoi, A.I., Onwuka, F.C., Osuchukwu, N.C. Effect of Rauwolfia vomitoria Afzel (Apocynaceae) extract on serum amino transferase and alkaline phosphatase activities and selected indices of liver and kidney functions. african journal of biotechnology, 2009, vol. 8, no. 18, p. 4604–4607. .
Endpoint study #3: Akanji, M.A., Yakubu, M.T., Kazeem, M.I. Hypolipidemic and toxicological potential of aqueous extract of Rauvolfia vomitoria afzel root in wistar rats. journal of medical sciences (faisalabad), 2013, vol. 13, no. 4, p. 253–260. DOI: 10.3923/jms.2013.253.260. [DOI link]
Endpoint study #4: Ekong, Moses B., Peter, Aniekan I., Edagha, Innocent A., Ekpene, Ubong U., Friday, Daniel A. Rauwolfia vomitoria inhibits olfaction and modifies olfactory bulb cells. brain research bulletin, 2016, vol. 124, p. 206–213. DOI: 10.1016/j.brainresbull.2016.05.008. [DOI link]