EFSA
ecomole
vscht
  2. Rauvolfia tetraphylla L.

Rauvolfia tetraphylla L.

Family:
Rubiaceae
Approval state:
Approved
Number of articles retrieved:
115
Number of processed references:
15
Compositions
#1: reserpine in leaves #2: reserpine in stem #3: reserpine in roots #4: yohimbine in leaves #5: rauvotetraphyllines A-E in aerial parts #6: reserpine in roots #7: alkaloids in roots #8: indole alkaloids (ajmaline, yohimbine, isoreserpine, corynanthine, deserpidine, lankanescine) in roots #9: indole alkaloids (yohimbine, a-yohimbine, reserpiline, isoreserpiline, ajmaline and aricine) in leaves #10: labdane diterpene in stems #11: yohimbane alkaloid (α-yohimbine, isoreserpiline and tetrahydroalstonine) in leaves #12: alpha-yohimbine in leaves #13: 10-Methoxy tetrahydroalstonine in leaves #14: Isoreserpiline in leaves #15: reserpine in leaves #16: indole alkaloids in leaves #17: indole alkaloids (rauvotetraphyllines F–H, 17-epi-rauvotetraphylline F and 21-epi-rauvotetraphylline) in aerial parts #18: yohimbine in leaves #19: serpentine in roots #20: ajmaline in roots #21: ajmalicine in roots #22: yohimbine in roots #23: ajmalicine in leaves #24: ajmaline in leaves #25: serpentine in leaves #26: reserpine in roots #27: reserpine in leaves #28: ajmalicine in roots #29: reserpine in roots #30: N(a)-Demethylaccedine in stem bark
Endpoint Studies
#1: Lethal dose in rats #2: body weight and food consumption among rats #3: well tolerated daily intake in rats
Genotoxicity
Composition #1: Panda, Sangram K., Pattanayak, Priyabrata., Oraon, Awadhesh., Parhi, Pravat K. Quantitative estimation of reserpine in different parts of R. serpentina and R. tetraphylla by using HPTLC. pharmacia lettre, 2010, vol. 2, no. 5, p. 363–370. .
Composition #2: Panda, Sangram K., Pattanayak, Priyabrata., Oraon, Awadhesh., Parhi, Pravat K. Quantitative estimation of reserpine in different parts of R. serpentina and R. tetraphylla by using HPTLC. pharmacia lettre, 2010, vol. 2, no. 5, p. 363–370. .
Composition #3: Panda, Sangram K., Pattanayak, Priyabrata., Oraon, Awadhesh., Parhi, Pravat K. Quantitative estimation of reserpine in different parts of R. serpentina and R. tetraphylla by using HPTLC. pharmacia lettre, 2010, vol. 2, no. 5, p. 363–370. .
Composition #4: Kumar, Arvind., Bhardwaj, M. K., Upadhyay, A. K., Tiwari, Anupa., Ohdar, Bikram Deo. Quantitative determination of yohimbine alkaloid in the different part of the Rauvolfia tetraphylla. journal of chemical and pharmaceutical research, 2011, vol. 3, no. 2, p. 907–910. .
Composition #5: Gao, Yuan., Zhou, Dong-Sheng., Kong, Ling-Mei., Hai, Ping., Li, Yan., Wang, Fei., Liu, Ji-Kai. Rauvotetraphyllines A-E, new indole alkaloids from Rauvolfia tetraphylla. natural products and bioprospecting, 2012, vol. 2, no. 2, p. 65–69. .
Composition #6: Bindu, S., Rameshkumar, K. B., Kumar, Brijesh., Singh, Awantika., Anilkumar, C. Distribution of reserpine in Rauvolfia species from India - HPTLC and LC-MS studies. industrial crops and products, 2014, vol. 62, p. 430–436. .
Composition #7: Bindu, S., Rameshkumar, K. B., Kumar, Brijesh., Singh, Awantika., Anilkumar, C. Distribution of reserpine in Rauvolfia species from India - HPTLC and LC-MS studies. industrial crops and products, 2014, vol. 62, p. 430–436. .
Composition #8: Arambewela, LSR., Madawela, G. Alkaloids from Rauvolfia canescens. pharmaceutical biology, 2001, vol. 39, no. 3, p. 239–240. DOI: 10.1076/phbi.39.3.239.5923. [DOI link]
Composition #9: Arambewela, LSR., Madawela, G. Alkaloids from Rauvolfia canescens. pharmaceutical biology, 2001, vol. 39, no. 3, p. 239–240. DOI: 10.1076/phbi.39.3.239.5923. [DOI link]
Composition #10: Brahmachari, Goutam., Mandal, Lalan Ch., Gorai, Dilip., Mondal, Avijit., Sarkar, Sajal., Majhi, Sasadhar. A new labdane diterpene from Rauvolfia tetraphylla Linn. (Apocynaceae). journal of chemical research, 2011, no. 12, p. 678–680. DOI: 10.3184/174751911X13220462651507. [DOI link]
Composition #11: Verma, Ram Kishore., Gupta, Shikha., Gupta, Madan Mohan., Srivastava, Santosh Kumar. A SIMPLE ISOCRATIC HPLC METHOD FOR THE SIMULTANEOUS DETERMINATION OF ANTIPSYCHOTIC INDOLE ALKALOIDS IN RAUWOLFIA TETRAPHYLLA . journal of liquid chromatography & related technologies, 2012, vol. 35, no. 7, p. 937–950. DOI: 10.1080/10826076.2011.615086. [DOI link]
Composition #12: Gupta, Shikha., Shanker, Karuna., Srivastava, Santosh K. HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: A study of organic/green solvent and continuous/pulse sonication . journal of pharmaceutical and biomedical analysis, 2012, vol. 66, p. 33–39. DOI: 10.1016/j.jpba.2012.02.018. [DOI link]
Composition #13: Gupta, Shikha., Shanker, Karuna., Srivastava, Santosh K. HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: A study of organic/green solvent and continuous/pulse sonication . journal of pharmaceutical and biomedical analysis, 2012, vol. 66, p. 33–39. DOI: 10.1016/j.jpba.2012.02.018. [DOI link]
Composition #14: Gupta, Shikha., Shanker, Karuna., Srivastava, Santosh K. HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: A study of organic/green solvent and continuous/pulse sonication . journal of pharmaceutical and biomedical analysis, 2012, vol. 66, p. 33–39. DOI: 10.1016/j.jpba.2012.02.018. [DOI link]
Composition #15: Gupta, Shikha., Shanker, Karuna., Srivastava, Santosh K. HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: A study of organic/green solvent and continuous/pulse sonication . journal of pharmaceutical and biomedical analysis, 2012, vol. 66, p. 33–39. DOI: 10.1016/j.jpba.2012.02.018. [DOI link]
Composition #16: Gupta, Shikha., Khanna, Vinay Kumar., Maurya, Anupam., Bawankule, Dnyaneshwar Umrao., Shukla, Rajendra Kumar., Pal, Anirban., Srivastava, Santosh Kumar. Bioactivity guided isolation of antipsychotic constituents from the leaves of Rauwolfia tetraphylla L. . fitoterapia, 2012, vol. 83, no. 6, p. 1092–1099. DOI: 10.1016/j.fitote.2012.04.029. [DOI link]
Composition #17: Gao, Yuan., Zhou, Dong-Sheng., Hai, Ping., Li, Yan., Wang, Fei. Hybrid Monoterpenoid Indole Alkaloids Obtained as Artifacts from Rauvolfia tetraphylla . natural products and bioprospecting, 2015, vol. 5, no. 5, p. 247–253. DOI: 10.1007/s13659-015-0074-2. [DOI link]
Composition #18: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #19: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #20: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #21: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #22: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #23: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #24: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #25: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #26: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #27: Kumar, Sunil., Singh, Awantika., Bajpai, Vikas., Srivastava, Mukesh., Singh, Bhim Pratap., Ojha, Sanjeev., Kumar, Brijesh. Simultaneous Determination of Bioactive Monoterpene Indole Alkaloids in Ethanolic Extract of Seven Rauvolfia Species using UHPLC with Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry . phytochemical analysis, 2016, vol. 27, no. 5, p. 296–303. DOI: 10.1002/pca.2631. [DOI link]
Composition #28: Pandey, Devendra Kumar., Radha., Dey, Abhijit. A validated and densitometric HPTLC method for the simultaneous quantification of reserpine and ajmalicine in Rauvolfia serpentina and Rauvolfia tetraphylla . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2016, vol. 26, no. 5, p. 553–557. DOI: 10.1016/j.bjp.2016.04.002. [DOI link]
Composition #29: Pandey, Devendra Kumar., Radha., Dey, Abhijit. A validated and densitometric HPTLC method for the simultaneous quantification of reserpine and ajmalicine in Rauvolfia serpentina and Rauvolfia tetraphylla . revista brasileira de farmacognosia-brazilian journal of pharmacognosy, 2016, vol. 26, no. 5, p. 553–557. DOI: 10.1016/j.bjp.2016.04.002. [DOI link]
Composition #30: MARTINEZ, JA., VELEZ, H., SANTANA, T. AN ALKALOID FROM 2 RAUWOLFIA SPP. phytochemistry, 1989, vol. 28, no. 3, p. 961–962. DOI: 10.1016/0031-9422(89)80160-8. [DOI link]
Endpoint study #1: Tamboli, S.R., Pandit, R.S. Acute toxicity evaluation of Rauvolfia tetraphylla leaf extract in rat by up and down method. international journal of pharmaceutical and clinical research, 2014, vol. 6, no. 4, p. 316–319. .
Endpoint study #2: Tamboli, S.R., Pandit, R.S. Subacute toxicity evaluation of Rauvolfia tetraphylla methanolic leaf extract in Sprague dawley rat. international journal of pharmaceutical sciences review and research, 2015, vol. 34, no. 1, p. 152–157. .
Endpoint study #3: Tamboli, S.R., Pandit, R.S. Subacute toxicity evaluation of Rauvolfia tetraphylla methanolic leaf extract in Sprague dawley rat. international journal of pharmaceutical sciences review and research, 2015, vol. 34, no. 1, p. 152–157. .